ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 22: Issue 4 (Feb 2024): Pregnancy and Kidney Disease is now available online.
RE: IgG4 related disease with slowly rising IgG4 levels 6 minutes ago
I don't think that anyone has a good evidence based answer to your Challenging question. I would watch and wait.. ------------------------------...
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RE: IgG4 related disease with slowly rising IgG4 levels 7 minutes ago
Another suggestion : Checking UAlb/Cr and UPr/Cr on same sample of urine or U-protein electrophoresis for tubular proteinuria. ------------------...
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RE: IgG4 related disease with slowly rising IgG4 levels 9 minutes ago
Doubling of IgG4 level is worrisome. You may want to check CRP and sedimentation rate (elevated in 40 - 50%of patients) and PET-CT scanning. If the...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 14 minutes ago
Here’s what may be considered plausible: -The recalcitrant Hypercalcemia is likely from a combination of elevated PTHrp (paraneoplastic), bone met...
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IgG4 related disease with slowly rising IgG4 levels 53 minutes ago
A 73 yr old male presented to me 2 years ago with an acute deterioration of renal function and his creatinine peaked at 4.5. His renal biopsy showe...
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RE: Volunteer by May 8 to serve as a case report reviewer for Kidney Week 2024! 3 hours ago
Thanks for your question! Full details on the scoring system will be explained upon receiving reviewer assignment. If you haven't already, please c...
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RE: Volunteer by May 8 to serve as a case report reviewer for Kidney Week 2024! 3 hours ago
Thank you for your interest! Please complete this form by May 8 to be considered: https://www.surveymonkey.com/r/65T5VW5 ------------------------...
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RE: Request for Expert Opinions on Chronic Interstitial Nephritis Management 4 hours ago
we had a reference yesterday for interstitial disease associated with ANCA but that is unusual and pt was on hydralazine and much higher MPO. Thi...
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RE: Request for Expert Opinions on Chronic Interstitial Nephritis Management 4 hours ago
The + PR3 ANCA is highly unusual for a drug induced Interstitial nephritis, except Hydralazine. I suspect that this is an auto-immune disease. It m...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 4 hours ago
It would be interesting to know if this patient's renal phosphate wasting is due to elevated FGF-23. The very high 1,25-D level is interesting and ...
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RE: LN not in remission 5 hours ago
A "response" to RTX (or any anti-CD20 MoAb) is going to be very difficult to judge, short of a near complete remission, due to the possible superim...
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RE: Access to dialysis morbid obese non mobile 6 hours ago
Thanks a lot Dr for that clarification I totally agree with your opinion about the need of blood clearances And if the problem of PD in such pati...
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RE: LN not in remission 6 hours ago
Hi thanks for case. This patient is on a lot of medication . Is he compliant ? If we think rituximab is not working in general then not related t...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 6 hours ago
I have seen that article ( appreciate you sending it ). It appears my pt was somewhat different in that 1. He never had an elevated PTHrp... only 1...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 6 hours ago
Dr. Qualheim: Regarding your patient with ? sarcoma and 1-25 D3-related hypercalcemia, simultaneously elevated PTHrp and 1-25 D3 with hypercalcemia...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 7 hours ago
Has MAP kinase inhibitor ever been used in this patient? According to my reading (not experience) such agents may be effective in controlloibg the ...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 8 hours ago
In regards to my earlier post about ketoconazole and HCM; the pt I was alluding to had a Paraneoplastic syndrome presumed from a LUQ mass ( surgeon...
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RE: Volunteer by May 8 to serve as a case report reviewer for Kidney Week 2024! 8 hours ago
I am willing to review the case report. Regards Anant S Pilawan ------------------------------ Anant Pilawan MD, MBBS DEPARTMEN...
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RE: Volunteer by May 8 to serve as a case report reviewer for Kidney Week 2024! 15 hours ago
Thanks for your response. Kindly give me an idea of your scoring criteria. Thank you
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RE: Possible hydralazine associated ANCA vasculitis/lupus,/treat or not 23 hours ago
Thanks Dr Venkat and Dr Nauman Dr Venkat patient has been on spironolactone 50 mg since 9/2023 Dr Nauman her DSDNA. Was negative ----------------...
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RE: Kidney Showing Severe Arteriosclerosis With Patient Has No HTN 1 day ago
Moderate to severe arteriosclerosis can be seen in kidney biopsies with familial dysautonomia (characterized by low blood pressure, impaired kidney...
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RE: Kidney Showing Severe Arteriosclerosis With Patient Has No HTN 1 day ago
No diabetes and no clinical signs suggestive of scleroderma also his BP has been very low in the clinic --------------------------------- Ali Ayes...
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Request for Expert Opinions on Chronic Interstitial Nephritis Management 1 day ago
Patient Profile: - Age/Sex: 60-year-old South Asian male - Past Medical History: - Type 2 Diabetes Mellitus (managed with insulin) - Depression/A...
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RE: Kidney Showing Severe Arteriosclerosis With Patient Has No HTN 1 day ago
Normal kidney aging can be associated with arterio-and arteriolo- sclerosis, even in the absence of elevated blood pressure but this degree of prot...
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RE: Proteinuria, hypoalbunimia management during pregnancy 1 day ago
Dr Ahmed if Cr does not come down after cessation of CNI, at what point would you consider delivery. ------------------------------ Awais Nauman ...
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RE: Kidney Showing Severe Arteriosclerosis With Patient Has No HTN 1 day ago
Senile arteriolosclerosis ------------------------------ Awais Nauman HMC Doha ------------------------------
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RE: Proteinuria, hypoalbunimia management during pregnancy 1 day ago
Thanks everyone. Dr Rodby, after the urine being negative for hematuria, we found more analyses showing micro-hemaruria. will stop CNI as...
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Kidney Showing Severe Arteriosclerosis With Patient Has No HTN 1 day ago
Would Appreciate your input : 78-year-old male patient was referred to me by my clinic 6 months ago for abnormal renal function test, his creatini...
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RE: Possible hydralazine associated ANCA vasculitis/lupus,/treat or not 1 day ago
Is it Hydralazine induced Lupus Interstitial Nephritis rather than Hudralazine induced AAV associated Interstitial Nephritis? In this study 5 pati...
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RE: Volunteer by May 8 to serve as a case report reviewer for Kidney Week 2024! 1 day ago
Thank you for your interest in reviewing trainee case reports! For time commitment, ASN's goal is to assign no more than 60 case reports (abstracts...
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RE: Volunteer by May 8 to serve as a case report reviewer for Kidney Week 2024! 1 day ago
Good evening. I am willing to serve as a reviewer. Thank you for the opportunity.Dr. Onu Ugochi Chika
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 1 day ago
Regarding the mechanism(s) of hypercalcemia and hypophosphatemia in this patient: 1. It has been suggested that hypercalcemia may directly cause re...
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RE: Volunteer by May 8 to serve as a case report reviewer for Kidney Week 2024! 1 day ago
Hi What is the time commitment and expectations on this? Thanks ------------------------------ Jose Agraz PhD postdoctoral fellow university ...
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RE: Possible hydralazine associated ANCA vasculitis/lupus,/treat or not 1 day ago
I assume spironolactone is being used for BP control since proteinuria is not severe. What is the dose of spironolactone? Some of the recent increa...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 1 day ago
Agree with Dr Rodby's comments. I would not use fluconozole as elevated 125 would like increase and not decrease the phosphate. It could be from PT...
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RE: Possible hydralazine associated ANCA vasculitis/lupus,/treat or not 1 day ago
Thanks a lot Dr Glassock and Dr Rudby Very helpful No Eosinophilia IF on Bx negative Don’t have IgG4 will check I was thinking to treat with ste...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 1 day ago
That 1-25 is crazy high but I dont see how that causes the hypoPO4 and PO4 wasting. FGF23 is rare in breast cancer but not unheard of https://p...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 1 day ago
You might ask your Medical Oncologists if a MAP kinase inhibitor (like Trametinib ) would have any palliative value as these agents may help to all...
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RE: LN not in remission 1 day ago
Do you? 1) rebiopsy and see if that helps you decide - I think you will find a mixture of old and new MGN, I doubt it will be only old MGN as pro...
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RE: Access to dialysis morbid obese non mobile 1 day ago
Thanks Roger for asking. We have done home training before in circumstances like this, but in terms of scheduling it takes a nurse out of the uni...
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RE: Possible hydralazine associated ANCA vasculitis/lupus,/treat or not 1 day ago
what an odd ending to what I though was an obvious story. The pan-serology is typical for hydralazine but the pathology and urine are not, at ...
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RE: Proteinuria, hypoalbunimia management during pregnancy 1 day ago
I applaud my wiser colleagues on this one. I will be shocked it the Genetic testing does not confirm a COL4A5 mutation. And even if it doesn't, t...
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RE: Proteinuria, hypoalbunimia management during pregnancy 1 day ago
I would stop both steroids and CNI.This is most likely X-linked Alport syndrome, as has been suspected all along.. . ---------------------------...
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RE: Proteinuria, hypoalbunimia management during pregnancy 1 day ago
Kidney biopsy results are attached. COL4 mutation result pending. proteinuria down from 6.95 (2 weeks ago to 4.68 gm/24 hour but serum Album...
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RE: Possible hydralazine associated ANCA vasculitis/lupus,/treat or not 1 day ago
No hematuria, non-glomerular proteinuria , impaired GFR and mainly interstitial nephritis on kidney biopsy. Serology and C levels suggest Hydralazi...
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RE: Volunteer by May 8 to serve as a case report reviewer for Kidney Week 2024! 1 day ago
I can act as a reviewer if you still need! Thanks, Arti ------------------------------ Arti Dhoot MD Winnipeg MB (647) 455-1601 --------...
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RE: LN not in remission 1 day ago
I agree that value of IS is not clear at this time. Looks like burned-out disease with residual glomerular damage. ------------------------------...
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RE: Refractory Hypercalcemia of Malignancy with hypophosphatemia (elevated 1,25-OH VitD and PTHrP) 1 day ago
I have had success using ketoconazole in situations like this where " non-renal" CYP27B1 function ( ex. Sarcoid macrophage production of 1,25 di-oh...
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Possible hydralazine associated ANCA vasculitis/lupus,/treat or not 1 day ago
I would appreciate expert input on the 66 year-old Caucasian female with no history of smoking History of hypertension, she tell me controlled firs...
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RE: LN not in remission 2 days ago
The pathogenesis of sub-epithelial ED deposition of Ig in "pure" Lupus MN is unknown and Laboratory findings suggestive of inflammation are general...
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