Suffocation of the Kidney: Ischemia and Its Consequences

November 20, 2016 | 10:00 AM - 12:00 PM

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Basic/Clinical Science Session

Suffocation of the Kidney: Ischemia and Its Consequences

November 20, 2016 | 10:00 AM - 12:00 PM

Location: W183B

Session Description

Ischemia is an essential factor of AKI. Furthermore, chronic hypoxia plays a crucial role as a final common pathway of CKD to ESKD. Anemia in CKD decreases oxygen delivery to the vital organs. Hypoxia-inducible factor (HIF) serves as a center of the defensive system against hypoxia, and recent clinical trials of HIF activators (prolyl hydroxylase inhibitors) shed new light on the treatment of anemia in CKD and a hope for future therapies against AKI and CKD. This session addresses these topics.

Session Objectives

Upon completion of this session, the participant will be able to: 1. describe a pathophysiological role of hypoxia in AKI and CKD; and 2. explain the risks and benefits of HIF activators.

Learning Pathways

  • Acute Kidney Injury
  • Chronic Kidney Disease

Moderators

  • Kai-Uwe Eckardt, MD
  • Jaap A. Joles, PhD, DVM

Lectures

Interaction between HIF and TGF-β Add to your Outlook, Google, Yahoo, or Apple iCal Calendar
10:00 AM - 10:30 AM
H. William Schnaper, MD

Novel Therapeutic Modality of Kidney Diseases and Its Complication by PHD Inhibition Add to your Outlook, Google, Yahoo, or Apple iCal Calendar
10:30 AM - 11:00 AM
Tetsuhiro Tanaka, MD, PhD, FASN

Hemodynamic Changes and Hypoxia of the Kidney Add to your Outlook, Google, Yahoo, or Apple iCal Calendar
11:00 AM - 11:30 AM
Prabhleen Singh, MD, MPH

MicroRNA and Epigenetic Changes by Hypoxia Add to your Outlook, Google, Yahoo, or Apple iCal Calendar
11:30 AM - 12:00 PM
Zheng Dong, PhD, FASN