Leslie S. Gewin, MD, WIN Faculty
Leslie Gewin, M.D. is a physician-scientist who graduated from Princeton University and received her medical training at University of Alabama at Birmingham. She completed an internal medicine residency at Johns Hopkins Medical Institute and her nephrology fellowship at Vanderbilt University. Although she really enjoyed clinical care, Dr. Gewin felt that more therapeutic options for patients with chronic kidney disease were greatly needed. Therefore, as part of her fellowship, she joined the basic science laboratory of Roy Zent, M.D., Ph.D. to study the mechanisms underlying the progression of renal fibrosis, the common pathway leading from renal injury to end-stage renal disease.
Dr. Gewin has been on faculty in Vanderbilt’s Division of Nephrology since 2009. Her patient care responsibilities include attending on the general internal medicine service as well as the nephrology consult service at the Nashville VA. Dr. Gewin has a basic science laboratory that has received funding from both the VA and NIH. Her research focuses on understanding how growth factors (e.g. TGF-beta, Wnt/beta-catenin) alter the epithelial response to renal injury. Her lab uses mouse injury models as well as cell culture techniques to better understand the adaptive and pathophysiologic responses of renal tubules to various insults. In addition, she is co-director of the Clinical Applications of Scientific Evidence (CASE) Course for medical students.