ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 24: Issue 4 (Oct 2025): End-Stage Kidney Disease is now available online.
RE: IgA Nephropathy In A Transplant Recipient 22 minutes ago
Tarpeyo is supposed to work locally, specifically in the distal ileum, aiming to reduce the production of abnormal IgA from the gut-associated immu...
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RE: IgA Nephropathy with worsening proteinuria 31 minutes ago
I have no issues with using atrasentan or sparsentan . Unfortunately our health system will not approve either , without a trial of steroids as pe...
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RE: Atrasentan experience and first thoughts 35 minutes ago
Just as a follow up after 7 weeks His eGFR from a nadir of 31 ml/min is now 37 ml/ min His uPCR which was 0.8 grams per day , , unfortunately ha...
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RE: IgA Nephropathy In A Transplant Recipient 40 minutes ago
So this is de novo IgAN. Was the native kidneys of the recipient ever examined by IF. Was a zero time biopsy of the graft performed. . How can you ...
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RE: IgA Nephropathy with worsening proteinuria 44 minutes ago
I think I might try add on Atrasentan or stop RASi and Start Sparsentan. Alternatively, a 6 month course of moderate dose steroids in tapering dosa...
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RE: IgA Nephropathy with worsening proteinuria 1 hour ago
You have already optimized foundational treatment with ARB and Sglt2i. Despite that, the patient seems to have 1. Worsening renal function, decli...
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RE: IgA Nephropathy In A Transplant Recipient 2 hours ago
Biopsy proven IgAN. Original disease is reflux nephropathy. No vasculitis. --------------------------------- Gary Singer MD, FASN Partner Midwest...
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RE: IgA Nephropathy with worsening proteinuria 2 hours ago
M0E0S1T0 - C0 UA - 2 + blood, 3+ protein, 20-40 RBC/HPF BMI 28 BP 132/75 ------------------------------ ChiragVaidya -------------------...
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RE: IgA Nephropathy In A Transplant Recipient 6 hours ago
Not a good idea , in my opinion. Maybe try anti-April or April -BAFF when they become available. Are you sure this is recurrent IgAN not IgAV ? ...
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IgA Nephropathy In A Transplant Recipient 7 hours ago
Longstanding LRD kidney transplant recipient with biopsy proven IgA nephropathy. Current medications include prednisone, tacrolimus, sparsentan an...
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RE: treatment desision of igA vasculitis 12 hours ago
------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 ------------------------------
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RE: treatment desision of igA vasculitis 12 hours ago
Please see UpToDate for practice suggestions . The existing "guidance" is under revision, so new ones will be available soon. -----------------...
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RE: treatment desision of igA vasculitis 13 hours ago
M 0 e 0 s 0 t 0 c 1 1 mg/kg he was already taking at the time of biopsy for last 4 weeks Any guidelines in adults of treating igaV I searched kdigo...
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RE: treatment desision of igA vasculitis 13 hours ago
Adiagnosis of IgA V seems reasonably certain. With normal kidney function, stable low level of proteinuria, no nephrotic syndrome I think it might ...
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RE: IgA Nephropathy with worsening proteinuria 15 hours ago
What is the urine sediment exam or degree of hematuria by dipstick? What is the MEST-C score of the recent biopsy? What is the patients BMI and ave...
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IgA Nephropathy with worsening proteinuria 15 hours ago
I have a 51-year-old gentleman whom I started seeing in April 2024 after one of my senior partners retired. Patient has known history of biopsy-pro...
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treatment desision of igA vasculitis 15 hours ago
34 years old male with no prior co morbids presented with 10 days hx of abd pain arhtralgia and paedal swelling. before coming to us his work up sh...
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RE: Crescentic GN with atypical ANCA 15 hours ago
How recent was his COVID-19 infection? Was it severe? Was he treated? ------------------------------ Omar Maarouf MD Thomas Jefferson University ...
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RE: Crescentic GN with atypical ANCA 1 day ago
Does 1 small cellular creascent (among 8 non-sclerotic glomeruli) , Mesangial C3 deposition , no IgG or monotypic dePosits, miderste exudation, sev...
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RE: Crescentic GN with atypical ANCA 1 day ago
20 Pack years, quit 35 yrs ago. I am wondering if the acute nephritis is the reason for the recent decline in renal function and its worth treat...
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RE: HIGH FERRIN IN HEMODIALYSIS PATINTS 1 day ago
Wow. George's paper is over 20 years old and still relevant. Yes, I have done my share of Indium scans.. Following excised of these old grafts in "...
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RE: HIGH FERRIN IN HEMODIALYSIS PATINTS 1 day ago
Correct. The same applies to a retained non-functional renal allograft. I have attached an oldie regarding infected vascular accesses written by my...
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RE: HIGH FERRIN IN HEMODIALYSIS PATINTS 1 day ago
Yes both have been described. A low grade smoldering failed AVG can be difficult to detect on physical exam alone. In practice, if the ESA dose is ...
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RE: HIGH FERRIN IN HEMODIALYSIS PATINTS 1 day ago
Absolutely Documented in PD best but also my experience in NDD-CKD and even those on HD, If CRP > 5 but [More] Files Attached DocumentRE: HIGH...
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RE: HIGH FERRIN IN HEMODIALYSIS PATINTS 1 day ago
After peridontal disease would also consider retained old vascular access grafts and transplant kidneys as another source of inflammation. ------...
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RE: Crescentic GN with atypical ANCA 1 day ago
Thanks- the nodular glomerulosclerosis is very impressive while crescentic disease is not. Pronase digestion is negative- no clear evidence for a d...
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RE: Crescentic GN with atypical ANCA 1 day ago
Thank you, Dr. Glassock and Dr. Rodby, for your valuable inputs Yes, he does not have DM Yes, the Congo red staining and DNAJB9 sta...
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RE: Crescentic GN with atypical ANCA 1 day ago
Could you post the entire biopsy report (deidentified)? ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 -...
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RE: Crescentic GN with atypical ANCA 1 day ago
He has a MGUS which is not uncommon in his age group, but a MCRS needs to be excluded, Has he had a bone marrow , that is typical in these situat...
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RE: Crescentic GN with atypical ANCA 1 day ago
Addendum- if the patient is not on Hydrakazine and kidney function is deteriorating further and you cannot evaluate for a complement activating lam...
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RE: Crescentic GN with atypical ANCA 1 day ago
If the patient is taking hydralazine, I would stop it and give a short course of steroids . Just an outside chance. -----------------------------...
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RE: Crescentic GN with atypical ANCA 1 day ago
Without any deposits by EM, Pronase digestion with LC staining for monotypism is not likely to add much but it might be done as a "lomg shot" ---...
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RE: Crescentic GN with atypical ANCA 1 day ago
Dr. Glassock, would you recommend pronase digestion? ------------------------------ M.N. Alhosaini ------------------------------
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RE: HIGH FERRIN IN HEMODIALYSIS PATINTS 1 day ago
Roxadostat HIF-prolyl hydroxylase enzyme inhibitor might be helpful in correcting the condition as its having inhibitory effect on bipcidin product...
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RE: HIGH FERRIN IN HEMODIALYSIS PATINTS 2 days ago
You are correct. Peri dental disease and chronic gingivitis is s a known reason for hypo response to erythropoietin. We don't always look into pati...
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RE: Crescentic GN with atypical ANCA 2 days ago
With a lambda LC MGUS , low C3 and C3 deposition thus might be an indirect form of MGRS with a lambda LC monoclonal Ig inhibiting Factor H activity...
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RE: HIGH FERRIN IN HEMODIALYSIS PATINTS 2 days ago
There has been a lot of mention of infections in this thread .. but often overlooked is dental and gum disease in dialysis patients that drives thi...
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RE: Iptacopan For IC- MPGN 2 days ago
While Iptacopan does not directly block the classic or Lectin pathways , it does inhibit the amplification loop , which is responsible for further ...
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Crescentic GN with atypical ANCA 2 days ago
87-year-old male with a PMH of chronic kidney disease stage IIIB with baseline eGFR of 45, h/o renal cancer s/p cryo ablation, hypertension, BPH, H...
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RE: Iptacopan For IC- MPGN 2 days ago
Since Pegcetacoplan binds to native C3 and prevents the action of the Classical, as well as the alternate pathway C3 Convertase to generate C3b wou...
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RE: bone mineral disorder 2 days ago
Agreed. Did a head CT scan show basal ganglia calcifications. If so, this case is very likely one of long standing hypoparathyroidism. , perhaps ...
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RE: bone mineral disorder 2 days ago
Findings nonspecific for ESKD except for low PTH. If chronically low PTH is suspected may one not see ectopic Ca deposits such as in the basal gang...
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RE: bone mineral disorder 2 days ago
Thank you for the two articles. ------------------------------ Anatole Besarab MD ABesarab Consulting Scottsdale AZ (734) 417-4793 --------------...
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RE: bone mineral disorder 2 days ago
The kidney outcomes in hypoparathyroidism are discussed by Gronemeyer in this recent Frontiers of Endocrinology article. ---------------------...
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RE: MPO-ANCA Vasculitis in the Setting of Infective Endocarditis - Infection triggered mimic? 2 days ago
Well said. Patience is golden ------------------------------ Anatole Besarab MD ABesarab Consulting Scottsdale AZ (734) 417-4793 ----------------...
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RE: bone mineral disorder 2 days ago
Here is a nice review of the skeletal manifestations of hypoparathyroidism by one of the world's expert Mishaela Rubin. ----------------------...
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RE: HIGH FERRIN IN HEMODIALYSIS PATINTS 2 days ago
Should a procalcitonin level be measures as an inflammatory marker. CRP does not always capture well different forms of inflammation. Any sign of a...
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RE: bone mineral disorder 2 days ago
The focus here has been on the metabolic issue of what form of bone disease is present. But the patient is quite uremic if the Cr is 20 mg/dL.I dou...
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RE: bone mineral disorder 2 days ago
Not true. In patients with this degree of CKD the urine calcium is always very low. Hypocalciuria is a feature of Advanced CKD. --------------...
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RE: bone mineral disorder 3 days ago
No nephrocalcinosis Isn't 24 h urine calcium is very low? Range is up to 250 Yahoo Mail: Search, Organize, Conquer
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