RE: Sigmoid Adenocarcinoma in Renal Tx patient on MMF/CyA/Pred - to Stop MMF or not 10 minutes ago

As per our extensive discussion as to whether a distal (left sided ) colon cancer is related to MMF ? And no evidence of extension beyond resection...

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RE: SLE - Pre-Pregnancy Immunosuppression swap dilemma 1 hour ago

Would add hydroxychloroquine if not already on it --------------------------------- Edgard Wehbe MD, FASN Wichita Nephrology Group Wichita KS ...

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RE: SLE - Pre-Pregnancy Immunosuppression swap dilemma 1 hour ago

What is the kids lesion? What about adding low dose Tacrolimus or Voclosporin to AZA and low dose steroids.? ------------------------------ Richa...

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SLE - Pre-Pregnancy Immunosuppression swap dilemma 3 hours ago

Nephrotic Syndrome - SLE -2003 ( Aza + Pred - till 2006 ) - 1st Relapse - Completed Cyclophosphamide - 6 months + MMF - 2nd Relapse(PCR 1030)-Se...

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RE: Sigmoid Adenocarcinoma in Renal Tx patient on MMF/CyA/Pred - to Stop MMF or not 3 hours ago

I have 2 questions, assuming that the damage already happened (the cancer), and hopefully it can be resected or treated, should we consider stoppin...

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RE: A 19-Year-Old Male with Frank Hematuria, Proteinuria, and Weak Anti-GBM Positivity 4 hours ago

No murmur RF pending Biopsy done today ECHO arranged --------------------------------- Mohamed Mahmoud MBBS NEPHROLOGIST MOH Egypt 00965 513...

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RE: Sigmoid Adenocarcinoma in Renal Tx patient on MMF/CyA/Pred - to Stop MMF or not 4 hours ago

It was an incidental finding. patient reported fresh PR bleeding. We did a colonoscopy and Bx of the Poly leading to the diagnosis and Surgery. ...

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RE: What FSGS is that ? 5 hours ago

Thanks prof glassock --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: One and half nephrectomy, normal looking GFR but hyperkalemia, question on K physiology 9 hours ago

Even in healthy subjects, SCr promptly doubles within 24 hrs of donor nephrectomy and even with maximum hypertrophy over subsequent few months of t...

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RE: A 19-Year-Old Male with Frank Hematuria, Proteinuria, and Weak Anti-GBM Positivity 9 hours ago

Rheumatoid factor? Cardiac murmurs? ------------------------------ K.K. Venkat MD Troy MI (248) 420 7798 ------------------------------

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RE: Membranous Nephropathy and necrotizing GN 11 hours ago

Trace Hematuria recently but 3+ hematuria initially . No CRP or ESR done. ------------------------------ Richard Glassock MD, FASN Laguna Woods ...

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RE: What FSGS is that ? 11 hours ago

FP = foot process . FPE= Foot process effacement = ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 ----...

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RE: Radiation therapy - peritoneal dialysis membrane 12 hours ago

Dear All I agree with Dr Rodby about no effect but we advise to insert the catheter by laparoscopic method where could see if there was any adhes...

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RE: Membranous Nephropathy and necrotizing GN 13 hours ago

Dr. Glassock: I might have missed your mention of the following: Microscopic hematuria/RBC casts? CRP/sed. rate? ----------------------------...

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RE: What FSGS is that ? 13 hours ago

If stored serum from the time of full nephrotic syndrome is available, anti-nephrin antibody testing on it may be informative. ------------------...

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RE: What FSGS is that ? 14 hours ago

Sorry dr jebur --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: anti gbm/mpo +ve in young female 14 hours ago

15mg/kg IV every 2 weeks may be too high a dose for an oligo-anuric patient. Watch out for pancytopenia ------------------------------ Richard G...

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RE: anti gbm/mpo +ve in young female 14 hours ago

I think she is will update next week When I am ward --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: anti gbm/mpo +ve in young female 14 hours ago

Iv Cyclo as per cyclops ( will double check ) I agree with you prof I would not use iv cyclo but that was discussed in local mdt Local mdt treati...

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RE: anti gbm/mpo +ve in young female 15 hours ago

What is the IV CYC dose you are using? If available , you could do single breathe CO inhalation test to detect occult DAH , but it win't make any d...

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RE: A 19-Year-Old Male with Frank Hematuria, Proteinuria, and Weak Anti-GBM Positivity 16 hours ago

We arranged for urgent biopsy --------------------------------- Mohamed Mahmoud MBBS NEPHROLOGIST MOH Egypt 00965 51377736 -------------------...

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RE: Proteinuric Patient With Normal Blood Pressure 16 hours ago

Thanks dr dastoor --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: anti gbm/mpo +ve in young female 17 hours ago

Thanks prof glassock I don’t think oral cyclo get removed with plex ? So standard daily dosing --------------------------------- Muhammad Sooba...

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RE: Membranous Nephropathy and necrotizing GN 17 hours ago

PLA2R + MGN increasing despite rituximab, although not [More]

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RE: What FSGS is that ? 17 hours ago

Thanks dr leiba @ prof glassock what does Fp mean? Sounds like AI driven biopsy interpretation could help here @ dr jab if what do you mean by MGD?...

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RE: A 19-Year-Old Male with Frank Hematuria, Proteinuria, and Weak Anti-GBM Positivity 18 hours ago

Fever, Nephrotic syndrome and Splenomegaly are not usual features of anti-GBM disease, but it is hard to ignore even a weakly positive anti-GBM tes...

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RE: A 19-Year-Old Male with Frank Hematuria, Proteinuria, and Weak Anti-GBM Positivity 20 hours ago

@Mohamed Mahmoud What did the kidney biopsy show? ------------------------------ Mario Rubin, M.D. Houston TX (713) 252-5539 ------------------...

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RE: A 19-Year-Old Male with Frank Hematuria, Proteinuria, and Weak Anti-GBM Positivity 20 hours ago

anti-gbm by ELIZA Planning for biopsy Typhoid. Brucellosis negative --------------------------------- Mohamed Mahmoud MBBS NEPHROLOGIST ...

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RE: A 19-Year-Old Male with Frank Hematuria, Proteinuria, and Weak Anti-GBM Positivity 20 hours ago

Do u know what method used to test for the anti-gbm This is looks like a false positive result or cross reactivity- The overall picture looks li...

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A 19-Year-Old Male with Frank Hematuria, Proteinuria, and Weak Anti-GBM Positivity 20 hours ago

I am seeking input on a 19-year-old male who presented with frank hematuria. He has no hemoptysis, rash, joint pain, or weight loss and no family h...

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RE: Membranous Nephropathy and necrotizing GN 1 day ago

I don't understand why you are not considering the biopsy a mixed MGN and ELISA-neg ANCA GN. A Cryo was negative? The biopsy had only epimembranous...

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RE: Membranous Nephropathy and necrotizing GN 1 day ago

The ANCA is by IIF and not specified by type (titer 1:640) . Both anti-MPO and PR3 are negative by ELISA. ------------------------------ Richard...

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RE: Membranous Nephropathy and necrotizing GN 1 day ago

If an HCV-related cryo is not present, why aren't you considering this a mixed ANCA (focal necrotizing) and anti-PLA2R (membranous) GN. Was the ANC...

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RE: Membranous Nephropathy and necrotizing GN 1 day ago

Thanks My personal opinion is that given the worsening nephrotic syndrome and renal function decline I would re-treat with anti CD20 (Rtx or Obi...

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RE: Membranous Nephropathy and necrotizing GN 1 day ago

Can you elaborate on increasing Anca . Is it pANcA or cAnca . The p- Anca can rise also in other diseases , like IBD , PBC etc . I would definitel...

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RE: Membranous Nephropathy and necrotizing GN 1 day ago

Both the anti-PLA2R and the ANCA (but not anti-MPO or anti-PR3 ) levels are increasing over 4 months since first dose of RTX. The proteinuria is al...

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RE: One and half nephrectomy, normal looking GFR but hyperkalemia, question on K physiology 1 day ago

It depends on how many nephrons he started with and the degree of "Compensatory" increase in snGFR in the remaining nephrons. , -----------------...

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RE: C3GN in a patient with VEXAS s/p SCT and metastatic SCC on immunotherapy 1 day ago

Thank you both so much!! It's so wonderful to have this forum to get advice from experts around the world. ------------------------------ Kelly L...

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RE: Membranous Nephropathy and necrotizing GN 1 day ago

Dr. Glassock what are the trends for anti PLA2R antibodies and ANCA titre ? Did the serum albumin and nephrotic improved with treatment? How frail...

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RE: What FSGS is that ? 1 day ago

Is it long term secondary FSGS with superadded MGD? But still only 30% of FPE is against. swift improvement on prednisolone is definite prove of Mi...

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RE: C3GN in a patient with VEXAS s/p SCT and metastatic SCC on immunotherapy 1 day ago

I agree with the approach suggested by Dr.Dastoor. ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 ------...

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RE: What FSGS is that ? 1 day ago

The FP width in patients with proven Prinary FSGS (untreated and in a well preserved glomerulus) is "invariably" above 3000 nm. The width is more v...

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RE: What FSGS is that ? 1 day ago

I guess I will do whole exome sequencing. Will figure out ancestry and consanguinity. Next time she flares..will repeat biopsy. My thought was...

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RE: C3GN in a patient with VEXAS s/p SCT and metastatic SCC on immunotherapy 1 day ago

Hello, C3 presentation on LM , can be MPGN, Mesangial Proliferation and even Membranous in rare cases . For PSGN, they will have alternate pathw...

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RE: renal limited microangiopathy 1 day ago

Interesting case indeed! It is sad that the patient is heading towards dialysis. As you know in TMA usually elevated LDH and low haptoglobin are n...

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RE: One and half nephrectomy, normal looking GFR but hyperkalemia, question on K physiology 1 day ago

May I ask if for some reason plasma Cr. is not correlating GFR due to poor muscle mass for example. Do we have Cystatin C? Hard to believe that som...

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RE: One and half nephrectomy, normal looking GFR but hyperkalemia, question on K physiology 1 day ago

https://journals.physiology.org/doi/epdf/10.1152/ajprenal.00195.2024 See this attached article- might help with understanding the pathophysiology....

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RE: anti gbm/mpo +ve in young female 1 day ago

i avoid IV CyC because of problems in calculating dosage in anuric patients. Oral CyC is standard care- no evidence at all that IV CyC is more effe...

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RE: C3GN in a patient with VEXAS s/p SCT and metastatic SCC on immunotherapy 1 day ago

Thank you Dr. Glassock and Dr. Dastoor for your replies! C3 was low (77.9), C4 was normal (25.4). The complement functional asssys and complement a...

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RE: anti gbm/mpo +ve in young female 1 day ago

Update - patient having iv cyclo 3 month with plex till anti gbm -ve Microcytic anaemia - heavy period but with normal Cxr could it be sub clinic...

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