RE: Kidney transplantation in a patient with monoclonal C3G 33 minutes ago

The efficacy of CAR-T depends on continual presence of chimeric cells direct to abnormal clones of CD19 clonotyoe . The immunosuppression required ...

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RE: FSGS with progressive worsening of renal function 2 hours ago

He did have PVR's of 500-700 per urology office , when they placed foley, the retention was not long enough to cause hydro. would not be able to at...

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RE: FSGS with progressive worsening of renal function 2 hours ago

His cr already at 3.5 in may'25 when he was started on this short course of abx. subsequent assessment was 5.9 in Jun'25- when he was admitted -...

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RE: Kidney transplantation in a patient with monoclonal C3G 3 hours ago

In addition to the points made by Dr Venkat, I would add that a disease like monoclonal C3GN will continue to fester with even a miniscule amount o...

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RE: FSGS with progressive worsening of renal function 5 hours ago

Although there is history of BPH and PVR was 500 mL, there was no hydronephrosis and SCr did not improve with placement of a Foley catheter. Subseq...

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Effect of Starvation/Malnutrition on Kidney Health 5 hours ago

The topic discussed in this post should not be viewed as a political issue. Instead, its purpose is to discuss this issue in the context of the Ame...

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RE: Bartter's syndrome vs primary hyperaldosteronism 6 hours ago

Thank you for the reference. hCina has an advantage for these kind of studies since Health care and data are centralized in large data sets, so get...

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RE: Bartter's syndrome vs primary hyperaldosteronism 6 hours ago

Here is the paper. As Dr Glassock said it's the first paper I know which does this systematically. I wish they had measured some function of Na int...

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RE: FSGS with progressive worsening of renal function 10 hours ago

Did the acute change in kidney function precede or follow the use of these anti-microbials ? ------------------------------ Richard Glassock MD, ...

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RE: FSGS with progressive worsening of renal function 11 hours ago

He is a white male, and did not pursue apol-1 ------------------------------ Vijayakumar Paramasivam MD Nephrologist Renal and Transplant Associa...

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RE: FSGS with progressive worsening of renal function 11 hours ago

yes,interstitial nephritis is out of proportion to secondary FSGS and may be attributable to acute and chronic obstruction ----------------------...

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RE: FSGS with progressive worsening of renal function 11 hours ago

calcium level wnl.- 8.8 . 25-OH Vitamin D 26 ng / ml( 30-100) ------------------------------ Vijayakumar Paramasivam MD Nephrologist Renal and...

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RE: FSGS with progressive worsening of renal function 11 hours ago

yes he received iv ceftriaxone followed by a 5 day course of cefpodoxime ------------------------------ Vijayakumar Paramasivam MD Nephrologist R...

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RE: FSGS with progressive worsening of renal function 11 hours ago

ck was wnl ------------------------------ Vijayakumar Paramasivam MD Nephrologist Renal and Transplant Associates of the North East Springfield ...

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RE: Ozempic in patients with Polycystic kidney disease, CKD4 & +/- DM2 17 hours ago

Please clarify your question about Ozempic (semaglutide) use in ADPKD Does your hypothetical patient with ADPKD have Obesity and how severe , Diabe...

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Ozempic in patients with Polycystic kidney disease, CKD4 & +/- DM2 18 hours ago

Hello everyone. I really appreciate it if someone share with me their experience, if ever, used Ozempic in patients with Polycystic kidney disease,...

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RE: Bartter's syndrome vs primary hyperaldosteronism 22 hours ago

pne of the drawbacks of not having a LIbrary is accessing hot of the press articles. Katest issue of H Human Hypertension I could look at was the J...

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RE: Bartter's syndrome vs primary hyperaldosteronism 23 hours ago

Dr. Besarab- good question. See Zhang CY, et al J Human Hypertens. July 16, 2025. Open Access. Very timely paper, just publushed last week. -----...

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RE: Bartter's syndrome vs primary hyperaldosteronism 23 hours ago

Dr Glassock Another test does not hit the mark. In all three of my case of negative saline suppression (including myself), the Melby test show...

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RE: Bartter's syndrome vs primary hyperaldosteronism 1 day ago

Thanks- another highly touted test bites the dust (like TTKG and UAG). ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (...

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RE: Kidney transplantation in a patient with monoclonal C3G 1 day ago

Two recent episodes of Pseudomonas bacteremia, persisting monoclonal gammopathy and clonal plasma cell expansion in the marrow are major concerns a...

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RE: Bartter's syndrome vs primary hyperaldosteronism 1 day ago

FYI, recent article in Ann Internal Med ------------------------------ John Mellas MD Nephrology and Hypertension Specialists St Louis MO ...

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RE: Kidney transplantation in a patient with monoclonal C3G 1 day ago

Difficult case. What is his current C3level? I assume that the lambda MC is interfering with the action of CFH in the circulation and causing a C-d...

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Kidney transplantation in a patient with monoclonal C3G 1 day ago

Dear colleagues, I'd like your thoughts about a case of a 40 y.o. man on hemodialysis for monoclonal C3G (Dense deposit disease) Here's a brief s...

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RE: FSGS with progressive worsening of renal function 1 day ago

Was APOL-1 genetic testing done and if variant present could this help explain his path ------------------------------ Jonathan Slater MD Renal &...

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RE: FSGS with progressive worsening of renal function 2 days ago

Here is another explanation: Secondary FSGS as Dr. Aledan stated Interstitial inflammation is manifestation of obstruction/reflux (especially ...

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RE: CKD , with pathology- higher Lambda than Kappa 2 days ago

Hello, kappa 53 lambda 43 ratio 1.2 Thank you! ! ------------------------------ Eithan Orlev MD Cincinnati OH (513) 488-6279 -------...

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RE: sglt2 2 days ago

Sheldon, I consider cost. as an important outcome variable poorly examined in our RCTs. Lets start with ARB of ACE., add a second or third generati...

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RE: sglt2 2 days ago

" I see too many patients over-medicated ARB or ACEi SGLT2i , Diuretics, Finerenone, and GLP-1. There needs to be SOME glomerular capillary pressur...

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RE: CKD , with pathology- higher Lambda than Kappa 2 days ago

What are the serum free light chain levels? ------------------------------ Nelson Leung MD Mayo Clinic Rochester MN (507) 208-1459 --------------...

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RE: FSGS with progressive worsening of renal function 2 days ago

In addition to the above could you tell us whether his corrected serum calcium was normal? Also vitamin D levels, if done?Long term vitamin D thera...

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RE: sglt2 2 days ago

UACR undetectable.UPCR 170mg/gSent from my iPhone

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RE: CKD , with pathology- higher Lambda than Kappa 2 days ago

Can we presume that albumin staining of TBM is negative? (the patient has T2DM). Unclear in the report. ------------------------------ Richard Gl...

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RE: FSGS with progressive worsening of renal function 2 days ago

Agree that this is secondary FSGS and AIN and agree with Dr. Venkat to slowly taper steroids. Any evidence of urosepsis? Did he received antibioti...

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RE: CKD , with pathology- higher Lambda than Kappa 2 days ago

The report is not clear as to which basement membrane show dominant lambda staining, it says the glomerular are negative in basement membrane show ...

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RE: FSGS with progressive worsening of renal function 2 days ago

Fenofibrate can cause true AKI (in addition to impairing proximal tubular creatinine secretion) with or without rhabdomyolysis. Was total CPK measu...

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RE: FSGS with progressive worsening of renal function 2 days ago

Albumin normal. Home meds amLODIPine 5 mg, aspirin 81 mg , atorvastatin 10 mg ,Coenzyme Q10, fenofibrate 145 mg,finasteride 5 mg,Synthroid 0....

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RE: FSGS with progressive worsening of renal function 2 days ago

Agree with Dr. Glassock that therapy directed against FSGS is not warranted. SCr was already decreasing (5.94 mg --> 4.8 mg/dL) even before prednis...

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RE: Severe AIN with Crescents 2 days ago

yes 1mg/kg of steroids, cr slow trend down from peak of 4.6 ( 7/6/25) to 3.0 ( 7/25/25). will update EM findings and photomicrographs if possible b...

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RE: Severe AIN with Crescents 3 days ago

Questions: 1. Did you treat patient with steroids for AIN? 2. EM findings? 3. SCr trend over last 2 weeks? ------------------------------ K.K. Ve...

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RE: CKD , with pathology- higher Lambda than Kappa 3 days ago

Thank you Dr Glassock for your input! ------------------------------ Eithan Orlev MD Cincinnati OH (513) 488-6279 ------------------------------

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RE: sglt2 3 days ago

Given biopsy findings of proteinaceous tubular casts and protein reabsorption droplets in tubular epithelial cytoplasm, it is important know UAlb/C...

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RE: FSGS with progressive worsening of renal function 3 days ago

The biopsy finding are not compatible with Primary FSGS (although no serum albumin reported) so IS therapy is not indicated for this reason, The re...

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RE: CKD , with pathology- higher Lambda than Kappa 3 days ago

Now I see that 4 gloms were present in IF (one globally sclerotic and three intact). The intact glomeruli slow "linear" deposits of Lambda > Kappa ...

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RE: CKD , with pathology- higher Lambda than Kappa 3 days ago

The attachment ------------------------------ Eithan Orlev MD Cincinnati OH (513) 488-6279 ------------------------------ Files Attached ...

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RE: CKD , with pathology- higher Lambda than Kappa 3 days ago

Thank you Dr Fogo Congo red was negative. No EM were done ( no glomeruli). I have attached the scan of the IF. Would any one repeat bio...

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RE: CKD , with pathology- higher Lambda than Kappa 3 days ago

I only see the summary of the report in the attachment. It would be important to have information on how many glomeruli were available for the immu...

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RE: sglt2 3 days ago

thank you everyone, ------------------------------ Shivangi Patel Nephrology Morristown NJ ------------------------------

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FSGS with progressive worsening of renal function 3 days ago

77/m with past medical history of HTN, HLD, CKD, BPH, OSA on CPAP, normal renal function until september 2024, with abnormal cr of 2.4 in April'202...

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RE: Severe AIN with Crescents 3 days ago

Final biopsy result now available Chronic, focally active crescentic glomerulonephritis (see note). Markedly active interstitial nephritis (w...

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