RE: Fibrillary GN 49 minutes ago

Isn’t DNAJB9 only found in primary fibrillary GN? So why do we look for secondary causes? --------------------------------- Alaa Nabih Abdalla nep...

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RE: Fibrillary GN 1 hour ago

No one really knows. Either would be OK in this case, if you want to use a maximally agressive therspy , with some attendant risks of AE. It is a j...

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RE: Fibrillary GN 1 hour ago

CD19 of zero mean that peripheral B cells have been adequately depleted but probably we need tissue B cells depletion so I suggest if you have acce...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 1 hour ago

Thanks a lot as Dr Glassok said Nifedepine should be stopped and you should increase losartan to maximum tolerated dose . Very rare MMF induce...

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RE: Fibrillary GN 1 hour ago

Thanks very much much CD19 zero Immunoglobulin assay : IgG ,IgM IgA all were low So my question can l strat cyclophosphamide now or not ?? ...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 6 hours ago

She's been on nifedipine for several years-could this side effect really present only now? I'll go ahead and stop it nonetheless. Also, any thought...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 6 hours ago

Sorry, I forgot to mention-creatinine was 1.18 mg/dL, 24-hour creatinine clearance was 92 mL/min, and urinalysis showed 0–3 RBCs/HPF. -----------...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 6 hours ago

The edema is due to Nifedipine - not MMF. It should be stopped. ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 38...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 6 hours ago

What happened to eGFR and hematuria?There are no FDA approved assays for gdIgA and the value of such monitoring in therapy if IgA remains unproven....

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MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 7 hours ago

Clinical Question: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 55-year-old woman with biopsy-confirmed IgA nephropathy (October 20...

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RE: Effect of Starvation/Malnutrition on Kidney Health 14 hours ago

During the winter of 1944–1945, the Nazi occupying forces imposed embargo on transport of food to the western Netherlands as a revenge for attacks ...

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RE: Fibrillary GN 14 hours ago

I agree fully with Dr. Rodby. If autoimmune, infections and cancer causes have been reasonably excluded , therapy of FGN is highly uncertain, but o...

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RE: Fibrillary GN 17 hours ago

It seems you have ruled out any secondary cases of Fib GN , cancer, paraprotein, hepatitis, I'm not sure everyone is always this diligent, well don...

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RE: Effect of Starvation/Malnutrition on Kidney Health 17 hours ago

Dr Soleimani, Thank you for your thoughtful comments on starvation and renal disease. I suspect you are correct that these multifaceted renal eff...

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Fibrillary GN 17 hours ago

Thanks our members community for helping us in difficult cases I need your help in this case A 52 year old female patient ,hypertensive 10 year...

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RE: Effect of Starvation/Malnutrition on Kidney Health 19 hours ago

A good article on the impact of malnutrition on the incidence of AKI. Xiang Xiang 1,✉, Xinchen Zhu 2, Lijuan Zhang 1 Int J Clin Pract. 2023...

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RE: Kidney transplantation in a patient with monoclonal C3G 1 day ago

The efficacy of CAR-T depends on continual presence of chimeric cells direct to abnormal clones of CD19 clonotyoe . The immunosuppression required ...

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RE: FSGS with progressive worsening of renal function 1 day ago

He did have PVR's of 500-700 per urology office , when they placed foley, the retention was not long enough to cause hydro. would not be able to at...

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RE: FSGS with progressive worsening of renal function 1 day ago

His cr already at 3.5 in may'25 when he was started on this short course of abx. subsequent assessment was 5.9 in Jun'25- when he was admitted -...

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RE: Kidney transplantation in a patient with monoclonal C3G 1 day ago

In addition to the points made by Dr Venkat, I would add that a disease like monoclonal C3GN will continue to fester with even a miniscule amount o...

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RE: FSGS with progressive worsening of renal function 1 day ago

Although there is history of BPH and PVR was 500 mL, there was no hydronephrosis and SCr did not improve with placement of a Foley catheter. Subseq...

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Effect of Starvation/Malnutrition on Kidney Health 1 day ago

The topic discussed in this post should not be viewed as a political issue. Instead, its purpose is to discuss this issue in the context of the Ame...

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RE: Bartter's syndrome vs primary hyperaldosteronism 1 day ago

Thank you for the reference. hCina has an advantage for these kind of studies since Health care and data are centralized in large data sets, so get...

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RE: Bartter's syndrome vs primary hyperaldosteronism 1 day ago

Here is the paper. As Dr Glassock said it's the first paper I know which does this systematically. I wish they had measured some function of Na int...

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RE: FSGS with progressive worsening of renal function 1 day ago

Did the acute change in kidney function precede or follow the use of these anti-microbials ? ------------------------------ Richard Glassock MD, ...

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RE: FSGS with progressive worsening of renal function 1 day ago

He is a white male, and did not pursue apol-1 ------------------------------ Vijayakumar Paramasivam MD Nephrologist Renal and Transplant Associa...

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RE: FSGS with progressive worsening of renal function 1 day ago

yes,interstitial nephritis is out of proportion to secondary FSGS and may be attributable to acute and chronic obstruction ----------------------...

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RE: FSGS with progressive worsening of renal function 1 day ago

calcium level wnl.- 8.8 . 25-OH Vitamin D 26 ng / ml( 30-100) ------------------------------ Vijayakumar Paramasivam MD Nephrologist Renal and...

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RE: FSGS with progressive worsening of renal function 1 day ago

yes he received iv ceftriaxone followed by a 5 day course of cefpodoxime ------------------------------ Vijayakumar Paramasivam MD Nephrologist R...

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RE: FSGS with progressive worsening of renal function 1 day ago

ck was wnl ------------------------------ Vijayakumar Paramasivam MD Nephrologist Renal and Transplant Associates of the North East Springfield ...

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RE: Ozempic in patients with Polycystic kidney disease, CKD4 & +/- DM2 2 days ago

Please clarify your question about Ozempic (semaglutide) use in ADPKD Does your hypothetical patient with ADPKD have Obesity and how severe , Diabe...

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Ozempic in patients with Polycystic kidney disease, CKD4 & +/- DM2 2 days ago

Hello everyone. I really appreciate it if someone share with me their experience, if ever, used Ozempic in patients with Polycystic kidney disease,...

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RE: Bartter's syndrome vs primary hyperaldosteronism 2 days ago

pne of the drawbacks of not having a LIbrary is accessing hot of the press articles. Katest issue of H Human Hypertension I could look at was the J...

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RE: Bartter's syndrome vs primary hyperaldosteronism 2 days ago

Dr. Besarab- good question. See Zhang CY, et al J Human Hypertens. July 16, 2025. Open Access. Very timely paper, just publushed last week. -----...

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RE: Bartter's syndrome vs primary hyperaldosteronism 2 days ago

Dr Glassock Another test does not hit the mark. In all three of my case of negative saline suppression (including myself), the Melby test show...

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RE: Bartter's syndrome vs primary hyperaldosteronism 2 days ago

Thanks- another highly touted test bites the dust (like TTKG and UAG). ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (...

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RE: Kidney transplantation in a patient with monoclonal C3G 2 days ago

Two recent episodes of Pseudomonas bacteremia, persisting monoclonal gammopathy and clonal plasma cell expansion in the marrow are major concerns a...

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RE: Bartter's syndrome vs primary hyperaldosteronism 2 days ago

FYI, recent article in Ann Internal Med ------------------------------ John Mellas MD Nephrology and Hypertension Specialists St Louis MO ...

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RE: Kidney transplantation in a patient with monoclonal C3G 2 days ago

Difficult case. What is his current C3level? I assume that the lambda MC is interfering with the action of CFH in the circulation and causing a C-d...

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Kidney transplantation in a patient with monoclonal C3G 2 days ago

Dear colleagues, I'd like your thoughts about a case of a 40 y.o. man on hemodialysis for monoclonal C3G (Dense deposit disease) Here's a brief s...

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RE: FSGS with progressive worsening of renal function 2 days ago

Was APOL-1 genetic testing done and if variant present could this help explain his path ------------------------------ Jonathan Slater MD Renal &...

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RE: FSGS with progressive worsening of renal function 3 days ago

Here is another explanation: Secondary FSGS as Dr. Aledan stated Interstitial inflammation is manifestation of obstruction/reflux (especially ...

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RE: CKD , with pathology- higher Lambda than Kappa 3 days ago

Hello, kappa 53 lambda 43 ratio 1.2 Thank you! ! ------------------------------ Eithan Orlev MD Cincinnati OH (513) 488-6279 -------...

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RE: sglt2 3 days ago

Sheldon, I consider cost. as an important outcome variable poorly examined in our RCTs. Lets start with ARB of ACE., add a second or third generati...

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RE: sglt2 3 days ago

" I see too many patients over-medicated ARB or ACEi SGLT2i , Diuretics, Finerenone, and GLP-1. There needs to be SOME glomerular capillary pressur...

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RE: CKD , with pathology- higher Lambda than Kappa 3 days ago

What are the serum free light chain levels? ------------------------------ Nelson Leung MD Mayo Clinic Rochester MN (507) 208-1459 --------------...

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RE: FSGS with progressive worsening of renal function 3 days ago

In addition to the above could you tell us whether his corrected serum calcium was normal? Also vitamin D levels, if done?Long term vitamin D thera...

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RE: sglt2 3 days ago

UACR undetectable.UPCR 170mg/gSent from my iPhone

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RE: CKD , with pathology- higher Lambda than Kappa Monday, July 28 @ 1:39 AM

Can we presume that albumin staining of TBM is negative? (the patient has T2DM). Unclear in the report. ------------------------------ Richard Gl...

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RE: FSGS with progressive worsening of renal function Monday, July 28 @ 1:00 AM

Agree that this is secondary FSGS and AIN and agree with Dr. Venkat to slowly taper steroids. Any evidence of urosepsis? Did he received antibioti...

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