RE: Unveiling Takayasu's Arteritis In A Young Female With Severe Hypertension 56 minutes ago

The results for anemia suggest iron deficiency may be present. However, peripheral smear not availabl3e. Suggest it ne done along with iron indices...

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RE: Primary vs Secondary IgAN 1 hour ago

If possible, one could consider staining the biopsy for KM55 (specific for gd-IGA molecules). If positive would further favor IgAN. Though data her...

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RE: mn with serum positive plar2 /negative on biopsy 1 hour ago

Rare cases of PLA2R negative staining can occur which are only detectable by mass spec https://www.sciencedirect.com/science/article/pii/S008525382...

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RE: rapidly progressive case of IgA nephropathy 3 hours ago

Unless this this is ANCA + disease, RTX in not indicated in IgAN. It might be effective in IgAV, but this patient did not have the clinical criteri...

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RE: rapidly progressive case of IgA nephropathy 3 hours ago

In addition to steroids and MMF,Rinvoq may also provide some added protection, opinion based --------------------------------- Bajinder Reen MD E...

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RE: rapidly progressive case of IgA nephropathy 5 hours ago

The reason I decided against pulse IV steroid therapy followed by oral steroid therapy is severe tolerability issues in this patient. She has previ...

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RE: rapidly progressive case of IgA nephropathy 5 hours ago

The patient may not have met the criteria for Cresenteric IgA , but perhaps now may meet it, perhaps only confirmed by biopsy. I agree with Dr. Gla...

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RE: Transplant Case 8 hours ago

There are several diagnostic possibilities for increasing proteinuria in this case. Sirolimus-induced podocytopathy (FSGS more likely than collapsi...

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RE: Transplant Case 8 hours ago

Unles significant contraindications to biopsy - proteinuria is indication for transplant biopsy especially if albumunuria ----------------------...

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RE: rapidly progressive case of IgA nephropathy 9 hours ago

This case does not meet the definition of IgAN with RPGN and extensive crescentic disease. Nevertheless there is abundant evidence of active inflam...

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RE: Unveiling Takayasu’s Arteritis In A Young Female With Severe Hypertension 13 hours ago

Thanks all for your comments. Her ESR was 30 mm/h, CRP was not done. MCV and MCHC were low. RFTs were stabilized and no increase after RAASi and ...

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RE: rapidly progressive case of IgA nephropathy 16 hours ago

Different things can be happening Did she experience macroscopic hematuria ? Sometimes AKI in IgAN is attractive to red blood cell cast nephropat...

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RE: rapidly progressive case of IgA nephropathy 18 hours ago

BP readings? Excessively controlled BP may cause AKI-on-CKD. Any abdominal bruits? Size of the two kidneys on ultrasound? In this female patient, e...

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RE: mn with serum positive plar2 /negative on biopsy 20 hours ago

The other possibility is that this is true PLA2R Disease and the IHC is false negative. I would treat with RTX either way and follow AntiPLA2R anti...

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RE: rapidly progressive case of IgA nephropathy 22 hours ago

There was patch interstitial fibrosis and tubular atrophy involving atleast 50% of the parenchyma. There was no evidence of any significant interst...

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RE: rapidly progressive case of IgA nephropathy 22 hours ago

Could it be TIN + ig a What does tubulo interstitium Look like ? Bw Belal --------------------------------- Muhammad Soobadar MBChB UK ---------...

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rapidly progressive case of IgA nephropathy 22 hours ago

I have a 54 year old pakistani female with history of rheumatoid arthritis diagnosed years ago in Pakistan (failed multiple meds and currently on r...

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RE: mn with serum positive plar2 /negative on biopsy 23 hours ago

Thanks prof glassock Pt is not diabetic . I will get non contrast ct , request biopsy stain for nel and thrombospondin Will ask if they can do IF...

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Transplant Case 23 hours ago

Dear colleagues would appreciate input. 72 female renal transplant patient switched to sirolimus for skin cancer . since 2011 2nd transplant...

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RE: mn with serum positive plar2 /negative on biopsy 23 hours ago

Is the patient Dizbetic. False pisitive ELISA for anti-PLA2R has been reported in thus circumstance . Please do an anti PLA2R using the IFA method....

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RE: Unveiling Takayasu’s Arteritis In A Young Female With Severe Hypertension 1 day ago

Consider steroid plus CellCept with with tb coverage if unresponsive consider tuclizamab --------------------------------- Bajinder Reen MD Etobi...

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RE: mn with serum positive plar2 /negative on biopsy 1 day ago

no chest infection or infection last year atleast i meant is tacrolimus better than rituximab at not causing infection? any data to support that?...

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mn with serum positive plar2 /negative on biopsy 1 day ago

75 male BG 2024- nephrotic range proteinuria, PCR 11g albumin 2 . haematoproteinuria on dipstick. 2024 jun 2024 creatine 1.20 , august 2024 when...

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RE: Unveiling Takayasu's Arteritis In A Young Female With Severe Hypertension 1 day ago

What is the type of anemia (hemoglobin 8 g/dl) that she has? Normal platelet count makes TMA secondary to severe hypertension unlikely. Is she iron...

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RE: VHL and kidney transplant 1 day ago

Dr. Sekar: Need more details. In this patient with von Hippel-Lindau disease, nephrectomy was done on both sides (total/partial) for RCC, a known c...

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VHL and kidney transplant 1 day ago

Thanks in advance Our group has a patient-- 55 y o M with st 3b CKD (on sglt2i, ARB), MPGN many years ago RCC with left nephrectomy and partia...

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RE: Unveiling Takayasu's Arteritis In A Young Female With Severe Hypertension 1 day ago

If IS therapy is chosen, concomitant therapy for TB will likely be required. ------------------------------ Richard Glassock MD, FASN Lagun...

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RE: Unveiling Takayasu's Arteritis In A Young Female With Severe Hypertension 1 day ago

Given the patients youth and severity of disease, I think consideration should be given to Steroid + MMF therapy and if refractory to these agents,...

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RE: Primary vs Secondary IgAN 1 day ago

No, I do not think so. But I guess it is possible. ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 -----...

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RE: Primary vs Secondary IgAN 1 day ago

I will try to work on getting initial biopsy report. Patient presented w pancytopenia and nephritis. Do you think presence of MMF may be the ca...

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RE: Unveiling Takayasu's Arteritis In A Young Female With Severe Hypertension 1 day ago

I haven't seen this in decades. Let's see what the experts think:@Duvuru Geetha @Peter Merkel ------------------------------ Mario Rubin,...

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RE: Primary vs Secondary IgAN 1 day ago

There is no evidence of active lesion on light microscopy to explain worsening of proteinuria. Diagnosing IgA nephropathy in the presence of IgA de...

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Unveiling Takayasu’s Arteritis In A Young Female With Severe Hypertension 1 day ago

An 18-years-old female was referred for evaluation of severe hypertension (BP 220/130 mmHg). She have a history of skin TB for 6 months (plaque in...

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RE: Post infective crescentic GN 1 day ago

If this patient has persistent renal dysfunction even after 8 weeks and has persistent low C3 levels we may consider it as infection triggered C3 G...

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RE: Primary vs Secondary IgAN 1 day ago

What did the original biopsy show with IF 2018. ? What was the basis for a diagnosis of SLE? . what is his eGFR and proteinuria now. Active IgAN wi...

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Primary vs Secondary IgAN 1 day ago

My partner has a case which I wanted to share with forum seeking further recommendations 36yo Hispanic man with hx of SLE/SLN dx in 2018 at that...

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RE: Post infective crescentic GN 1 day ago

Thank you for your replies. Full screening for underlying infection was performed. Similarly, wide range screening for immunological disease was pe...

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RE: Post infective crescentic GN 2 days ago

Candida pneumonia is uncommon in immunocompetent patients. Since patient had been on other antibiotics, could have had oropharyngeal candidiasis an...

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RE: Post infective crescentic GN 2 days ago

The evidence forc a favorable effect of immunosuppression in cases like this is very weak and inconsistent . I would likely chose further treatment...

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One Week Left - Nephrology Quiz and Questionnaire 2 days ago

There is only one week left to help contribute to the Nephrology Quiz and Questionnaire session at Kidney Week 2025. Please complete this 15-questi...

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One Week Left - Nephrology Quiz and Questionnaire 2 days ago

There is only one week left to help contribute to the Nephrology Quiz and Questionnaire session at Kidney Week 2025. Please complete this 15-questi...

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RE: Post infective crescentic GN 2 days ago

Seems like u have a case of Infection Related GN (IRGN) with , lack of IgG suggesting activation of alternate Complement pathway. As she has severe...

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RE: Post infective crescentic GN 2 days ago

Just to add the Immunoflouriscent study revealed predominenet C3 deposits. EM result is pending ------------------------------ Wael Jebur MD ...

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Post infective crescentic GN 2 days ago

52 year old lady presented to emergency department with fever and chills for few days with abdominal pain. Examination was unremarkable. Invest...

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RE: Severe Acute Tubular Injury With Severe Nephrotic Syndrome And Presumptive MCD diagnosis 2 days ago

Whistleblower says U.S. organ transplants corrupted by greed and bias This is so disappointing. Mt personal e mail is besaraba1943@outlook.com ...

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RE: Severe Acute Tubular Injury With Severe Nephrotic Syndrome And Presumptive MCD diagnosis 2 days ago

The discussion we are having is likely to become Tagged as inappropriate for the Forun, so I am writing to you from my personal e-mail. I am of U...

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RE: Severe Acute Tubular Injury With Severe Nephrotic Syndrome And Presumptive MCD diagnosis 2 days ago

One of the real troubling things that is happening in the Kurdish region has nothing to do with medicine or wars. The public education system is cr...

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RE: Severe Acute Tubular Injury With Severe Nephrotic Syndrome And Presumptive MCD diagnosis 2 days ago

As you so state, part of the problem is the "billing" department which has a temper temprum when they cannot get the bill out in a week and throws ...

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RE: Severe Acute Tubular Injury With Severe Nephrotic Syndrome And Presumptive MCD diagnosis 2 days ago

Thank you for your reply. Every nation needs to determine how much and to whom it must provide health care and how to provide the necessary funding...

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RE: Severe Acute Tubular Injury With Severe Nephrotic Syndrome And Presumptive MCD diagnosis 2 days ago

Dr. Weins I'll reply to a couple of comments that may be of general interest. I'll get in touch with you through email outside of the forum. I...

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