RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 5 hours ago

Could use topical minoxidil to mitigate the hair loss. --------------------------------- Graham Abra Redwood City CA -----------------------------...

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RE: Fibrillary GN 12 hours ago

Because FGN can occasionally undergo a spontaneous remission , I am very skeptical of case reports claiming efficacy for any therapy, including ste...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 12 hours ago

Agree to stop Nifedipine as it is the cause of pedal edema and increasing urinary albumin excretion. Pedal edema from DHP-CCBs can occur few days ...

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RE: Fibrillary GN 13 hours ago

Regarding the question of searching for secondary causes in DNAJB9-associated FGN, I think in most cases of glomerular diseases, we screened for au...

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RE: Fibrillary GN 13 hours ago

A case report of 2 cases with primary FGN showed great reduction of proteinuria and stabilization of kidney function with pulse MPD followed by ora...

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RE: Fibrillary GN 14 hours ago

Addendum- so far as I know Pegacetocoplan or Iptacopan have not been studies for efficacy and safety in FFN . I would not recommend their use in th...

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RE: Fibrillary GN 15 hours ago

In the broadest sense, all DNAJB9 deposition disease (FGN) is idiopathic. The use of the term "idiopathic" adds little to the description of DNAJB9...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 15 hours ago

I'm very sorry for the confusion. I just realized that I had already stopped the nifedipine and replaced it with losartan about six months ago. Tha...

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RE: Fibrillary GN 15 hours ago

DNAJB9 deposition is seen in both "Primary and Secondary" FGN. The use of the terms Primary and Secondary in tge context of FGN are confusing and d...

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RE: Fibrillary GN 17 hours ago

Or it is present in both idiopathic and secondary FGN --------------------------------- Alaa Nabih Abdalla nephrology fellow Egypt -------------...

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RE: Fibrillary GN 19 hours ago

Isn’t DNAJB9 only found in primary fibrillary GN? So why do we look for secondary causes? --------------------------------- Alaa Nabih Abdalla nep...

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RE: Fibrillary GN 20 hours ago

No one really knows. Either would be OK in this case, if you want to use a maximally agressive therspy , with some attendant risks of AE. It is a j...

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RE: Fibrillary GN 20 hours ago

CD19 of zero mean that peripheral B cells have been adequately depleted but probably we need tissue B cells depletion so I suggest if you have acce...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 20 hours ago

Thanks a lot as Dr Glassok said Nifedepine should be stopped and you should increase losartan to maximum tolerated dose . Very rare MMF induce...

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RE: Fibrillary GN 20 hours ago

Thanks very much much CD19 zero Immunoglobulin assay : IgG ,IgM IgA all were low So my question can l strat cyclophosphamide now or not ?? ...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 1 day ago

She's been on nifedipine for several years-could this side effect really present only now? I'll go ahead and stop it nonetheless. Also, any thought...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 1 day ago

Sorry, I forgot to mention-creatinine was 1.18 mg/dL, 24-hour creatinine clearance was 92 mL/min, and urinalysis showed 0–3 RBCs/HPF. -----------...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 1 day ago

The edema is due to Nifedipine - not MMF. It should be stopped. ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 38...

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RE: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 1 day ago

What happened to eGFR and hematuria?There are no FDA approved assays for gdIgA and the value of such monitoring in therapy if IgA remains unproven....

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MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 1 day ago

Clinical Question: MMF-related Hair Loss and Edema in IgAN – Continue or Hold? 55-year-old woman with biopsy-confirmed IgA nephropathy (October 20...

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RE: Effect of Starvation/Malnutrition on Kidney Health 1 day ago

During the winter of 1944–1945, the Nazi occupying forces imposed embargo on transport of food to the western Netherlands as a revenge for attacks ...

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RE: Fibrillary GN 1 day ago

I agree fully with Dr. Rodby. If autoimmune, infections and cancer causes have been reasonably excluded , therapy of FGN is highly uncertain, but o...

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RE: Fibrillary GN 1 day ago

It seems you have ruled out any secondary cases of Fib GN , cancer, paraprotein, hepatitis, I'm not sure everyone is always this diligent, well don...

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RE: Effect of Starvation/Malnutrition on Kidney Health 1 day ago

Dr Soleimani, Thank you for your thoughtful comments on starvation and renal disease. I suspect you are correct that these multifaceted renal eff...

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Fibrillary GN 1 day ago

Thanks our members community for helping us in difficult cases I need your help in this case A 52 year old female patient ,hypertensive 10 year...

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RE: Effect of Starvation/Malnutrition on Kidney Health 1 day ago

A good article on the impact of malnutrition on the incidence of AKI. Xiang Xiang 1,✉, Xinchen Zhu 2, Lijuan Zhang 1 Int J Clin Pract. 2023...

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RE: Kidney transplantation in a patient with monoclonal C3G 2 days ago

The efficacy of CAR-T depends on continual presence of chimeric cells direct to abnormal clones of CD19 clonotyoe . The immunosuppression required ...

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RE: FSGS with progressive worsening of renal function 2 days ago

He did have PVR's of 500-700 per urology office , when they placed foley, the retention was not long enough to cause hydro. would not be able to at...

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RE: FSGS with progressive worsening of renal function 2 days ago

His cr already at 3.5 in may'25 when he was started on this short course of abx. subsequent assessment was 5.9 in Jun'25- when he was admitted -...

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RE: Kidney transplantation in a patient with monoclonal C3G 2 days ago

In addition to the points made by Dr Venkat, I would add that a disease like monoclonal C3GN will continue to fester with even a miniscule amount o...

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RE: FSGS with progressive worsening of renal function 2 days ago

Although there is history of BPH and PVR was 500 mL, there was no hydronephrosis and SCr did not improve with placement of a Foley catheter. Subseq...

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Effect of Starvation/Malnutrition on Kidney Health 2 days ago

The topic discussed in this post should not be viewed as a political issue. Instead, its purpose is to discuss this issue in the context of the Ame...

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RE: Bartter's syndrome vs primary hyperaldosteronism 2 days ago

Thank you for the reference. hCina has an advantage for these kind of studies since Health care and data are centralized in large data sets, so get...

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RE: Bartter's syndrome vs primary hyperaldosteronism 2 days ago

Here is the paper. As Dr Glassock said it's the first paper I know which does this systematically. I wish they had measured some function of Na int...

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RE: FSGS with progressive worsening of renal function 2 days ago

Did the acute change in kidney function precede or follow the use of these anti-microbials ? ------------------------------ Richard Glassock MD, ...

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RE: FSGS with progressive worsening of renal function 2 days ago

He is a white male, and did not pursue apol-1 ------------------------------ Vijayakumar Paramasivam MD Nephrologist Renal and Transplant Associa...

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RE: FSGS with progressive worsening of renal function 2 days ago

yes,interstitial nephritis is out of proportion to secondary FSGS and may be attributable to acute and chronic obstruction ----------------------...

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RE: FSGS with progressive worsening of renal function 2 days ago

calcium level wnl.- 8.8 . 25-OH Vitamin D 26 ng / ml( 30-100) ------------------------------ Vijayakumar Paramasivam MD Nephrologist Renal and...

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RE: FSGS with progressive worsening of renal function 2 days ago

yes he received iv ceftriaxone followed by a 5 day course of cefpodoxime ------------------------------ Vijayakumar Paramasivam MD Nephrologist R...

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RE: FSGS with progressive worsening of renal function 2 days ago

ck was wnl ------------------------------ Vijayakumar Paramasivam MD Nephrologist Renal and Transplant Associates of the North East Springfield ...

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RE: Ozempic in patients with Polycystic kidney disease, CKD4 & +/- DM2 2 days ago

Please clarify your question about Ozempic (semaglutide) use in ADPKD Does your hypothetical patient with ADPKD have Obesity and how severe , Diabe...

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Ozempic in patients with Polycystic kidney disease, CKD4 & +/- DM2 3 days ago

Hello everyone. I really appreciate it if someone share with me their experience, if ever, used Ozempic in patients with Polycystic kidney disease,...

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RE: Bartter's syndrome vs primary hyperaldosteronism 3 days ago

pne of the drawbacks of not having a LIbrary is accessing hot of the press articles. Katest issue of H Human Hypertension I could look at was the J...

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RE: Bartter's syndrome vs primary hyperaldosteronism 3 days ago

Dr. Besarab- good question. See Zhang CY, et al J Human Hypertens. July 16, 2025. Open Access. Very timely paper, just publushed last week. -----...

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RE: Bartter's syndrome vs primary hyperaldosteronism 3 days ago

Dr Glassock Another test does not hit the mark. In all three of my case of negative saline suppression (including myself), the Melby test show...

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RE: Bartter's syndrome vs primary hyperaldosteronism 3 days ago

Thanks- another highly touted test bites the dust (like TTKG and UAG). ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (...

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RE: Kidney transplantation in a patient with monoclonal C3G 3 days ago

Two recent episodes of Pseudomonas bacteremia, persisting monoclonal gammopathy and clonal plasma cell expansion in the marrow are major concerns a...

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RE: Bartter's syndrome vs primary hyperaldosteronism 3 days ago

FYI, recent article in Ann Internal Med ------------------------------ John Mellas MD Nephrology and Hypertension Specialists St Louis MO ...

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RE: Kidney transplantation in a patient with monoclonal C3G 3 days ago

Difficult case. What is his current C3level? I assume that the lambda MC is interfering with the action of CFH in the circulation and causing a C-d...

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Kidney transplantation in a patient with monoclonal C3G 3 days ago

Dear colleagues, I'd like your thoughts about a case of a 40 y.o. man on hemodialysis for monoclonal C3G (Dense deposit disease) Here's a brief s...

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