G Proteins, Ligands, and Biased Agonists, Oh My! Unconventional Mechanisms of Signal Processing

November 17, 2016 | 02:00 PM - 04:00 PM

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Basic/Clinical Science Session

G Proteins, Ligands, and Biased Agonists, Oh My! Unconventional Mechanisms of Signal Processing

November 17, 2016 | 02:00 PM - 04:00 PM

Location: W183B

Session Description

Many physiological processes of the kidney are dependent on the activity of heterotrimeric G-proteins through the stimulation of cell surface G-protein–coupled receptors (GPCRs). There has been increasing evidence that the classic GPCR activation of heterotrimeric G-proteins is more complex than originally anticipated and is dependent on the repertoire of GPCR, G-protein subunits, and accessory proteins. There is also more information on the role of biased agonists. This session focuses on these topics and mechanisms related to the kidney.

Honorary Moderator: Josephine P. Briggs, MD

Session Objectives

Upon completion of this session, the participant will be able to: 1. describe the regulation of heterotrimeric G-proteins and G-protein signaling; 2. categorize the accessory proteins on heterotrimeric G-proteins in terms of their mode of action; 3. differentiate the biological role of G-proteins in various diseases/conditions of the kidney; and 4. describe the role of biased agonism in the activity of GPCRs.

Session Acknowledgements

In celebration of its 50th anniversary, ASN thanks former ASN Councilor Josephine P. Briggs, MD.

Learning Pathways

  • Chronic Kidney Disease
  • Pathology

Moderators

  • Bradley M. Denker, MD
  • Kevin R. Regner, MD, MS, FASN

Lectures

Receptor-Independent Regulation of Heterotrimeric G Proteins: An Overview Add to your Outlook, Google, Yahoo, or Apple iCal Calendar
02:00 PM - 02:30 PM
Stephen M. Lanier, PhD

Regulators of G-Protein Signaling (RGS) and Renal Hemodynamics, BP, and Renal Fibrosis Add to your Outlook, Google, Yahoo, or Apple iCal Calendar
02:30 PM - 03:00 PM
Patrick Osei-Owusu, PhD

Activators of G-Protein Signaling (AGS) Proteins in Renal Diseases Add to your Outlook, Google, Yahoo, or Apple iCal Calendar
03:00 PM - 03:30 PM
Frank Park, PhD

Biased Agonism at G-Protein–Coupled Receptors: The Promise and the Challenges Add to your Outlook, Google, Yahoo, or Apple iCal Calendar
03:30 PM - 04:00 PM
Sudarshan Rajagopal, MD, PhD