ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 23: Issue 4 (Oct 2024): Chronic Kidney Disease is now available online.
RE: Light chain cast nephropathy 6 minutes ago
Yes, I am aware of this algorithm from the Mayo Clinic concerning PLEX. It is based on weak evidence but substantial experience so it cannot be dis...
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RE: Light chain cast nephropathy 27 minutes ago
Has your proposal for a potential harmful effect of Proteosome inhibitors in LC Cast Nephropathy ever been examined clinically or does it remain as...
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RE: Re: pt with resistant HTN 54 minutes ago
Is it time for renal denervation? ------------------------------ Richard Glassock MD, FASN Laguna Woods CA (949) 388-8885 -----------------------...
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RE: Intra-ocular Anti-VEGF 57 minutes ago
I do not know of any way to mitigate the rusk of s renal TMA from intra-ocular use of bevacuzimab , other than go not use it in the first place. Do...
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Re: pt with resistant HTN 2 hours ago
Good afternoon. I am reaching out to you all about a difficult to control HTN patient that I am managing. Female in her 40s- African American- di...
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Intra-ocular Anti-VEGF 2 hours ago
I would like the community to weigh-in on how to mitigate kidney damage and proteinuria occurring in some of patient receiving intra-occular bevaci...
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RE: Light chain cast nephropathy 2 hours ago
1) TheraNova dialysis filter from Baxter has MWCO of about 45KD, which is good enough to remove monomeric light chains. 2) It was never examined...
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RE: Light chain cast nephropathy 3 hours ago
I agree with your reasoning Dr Glassock and of course a n=1 study cannot be considered as any evidence at all. But that was just a case vignette an...
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RE: post kidney transplant TMA 4 hours ago
Dr Glassock what I meant was that spontaneous TMA secondary to ABO antibodies will not occur after two weeks of transplant because of accommodation...
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RE: Light chain cast nephropathy 4 hours ago
MCO dialysis is not available in the USA . It has not been approved, largely because of negative results from trials. Your case report is appreciat...
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RE: post kidney transplant TMA 4 hours ago
Dr. Balan - I was not aware of the observation that de novo TMA due to ABO incompatibility in kidney transplantation usually spontaneously resolves...
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New resource for ASN members interested in nephrology research 4 hours ago
A new video resource titled "Increasing Opportunities for ASN Members in Research" was recently produced by the ASN Diversity, Equity, and Inclusio...
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New resource for ASN members interested in nephrology research 4 hours ago
A new video resource titled "Increasing Opportunities for ASN Members in Research" was recently produced by the ASN Diversity, Equity, and Inclusio...
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New resource for ASN members interested in nephrology research 4 hours ago
A new video resource titled "Increasing Opportunities for ASN Members in Research" was recently produced by the ASN Diversity, Equity, and Inclusio...
View Discussion
New resource for ASN members interested in nephrology research 4 hours ago
A new video resource titled "Increasing Opportunities for ASN Members in Research" was recently produced by the ASN Diversity, Equity, and Inclusio...
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RE: post kidney transplant TMA 4 hours ago
Continuing TMA in an ABOi transplant after more than two weeks is very unlikely to be due to an ABO antibody since accommodation almost always occu...
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RE: Light chain cast nephropathy 5 hours ago
If the light chain values are high, even if treatment is started today, I would use a medium cut off dialyzer like Theranova from Baxter. I find a ...
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Case Of Angimyolipoma 5 hours ago
Dear all, I would be Grateful for input I have seen a 31 female patient who had ultrasound of pelvis for pcos and was found to have 11.4 mm non sh...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 5 hours ago
Thank you Dr. Glascock. I just found a lupus panel of course it is negative; however, the ANA was positive just as you suspected at 1:160, of cours...
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RE: post kidney transplant TMA 6 hours ago
Dr. Lernan - is it very likely that this is antibody driven TMA, via iso-antibody in an ABO incompatible kidney transplant? ---------------------...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 6 hours ago
If the kidney biopsy diagnosis us correct these tests will not move the needle. A positive ANA would not be a surprise, but finding a clone would. ...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 7 hours ago
In addition to the information we currently have. We are still awaiting her lupus panel as well as a serum protein electrophoresis, urine protein e...
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RE: KTR with TB (Rifampicin Interaction With CNIs) 8 hours ago
This is very common and we in India see huge number of such patient. Most of us do not use Rifampicin based ATT but use Moxiflox in place of Rifamp...
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RE: post kidney transplant TMA 8 hours ago
Please show us how ABMR was excluded ------------------------------ [Mark] [Lerman] [MD,FASN,FACP,FAST] AST KPCOP EC [Past Medical Director Kidne...
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RE: Light chain cast nephropathy 10 hours ago
Thank you for your response, I agree, I wasn't sure since he had significant improvement with good oral hydration and avoiding further precipitatin...
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RE: Light chain cast nephropathy 10 hours ago
Thank you for the response. Yes, usually I have seen these patients coming to the hospital with AKI and diagnosed inpatient and getting treatment d...
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RE: Treatment Rationale for PLA2R-Induced Membranous Nephropathy with back groun Diabetic Nephropathy 12 hours ago
Sir, Kindly find enclosed with final kid Bx report SPECIMEN : Kidney biopsy panel 3 MICROSCOPY : Multiple sections stained with H&E, PAS, MT, si...
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RE: Treatment Rationale for PLA2R-Induced Membranous Nephropathy with back groun Diabetic Nephropathy 12 hours ago
Many thanks for the additional details of this case. With this new knowledge would anyone have treated thus patients with PLEX and a Proteosome inh...
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RE: Treatment Rationale for PLA2R-Induced Membranous Nephropathy with back groun Diabetic Nephropathy 12 hours ago
Sure Sir Here is summary in precise format Initial Presentation (2/10/2024): Patient presented with high PLA2R levels (>1500 RU/ML, EIA...
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RE: Light chain cast nephropathy 13 hours ago
While we do not have the quantitative serum FLC values in this case, I fully agree that they will be very high. In my opinion, the key to successfu...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 16 hours ago
Dr. Rodby. Thanks. Using an empirical approach to treatment of this condition that is similar to that used in PGNMID (a classic MGRS) makes reasona...
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RE: Treatment Rationale for PLA2R-Induced Membranous Nephropathy with back groun Diabetic Nephropathy 16 hours ago
Excellent point , Dr. Rodby. Yes, the Niles /MGH protocol includes oral steroids with a rapid taper. You are quite correct that we do not know for ...
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RE: Light chain cast nephropathy 16 hours ago
This patient's light chain load is huge, and while high cut off HD (not available here) would remove a lot more light chains than plex, if this pat...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 16 hours ago
Perhaps semantics but MGRS implies that the monoclonal gammopathy is clonal in nature. this has not been determined in these cases as far as I know...
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RE: Light chain cast nephropathy 16 hours ago
A very treatable disease, a clear diagnosis . He needs treatment yesterday. Any delay means lost nephrons . I would admit for starting chemotherapy...
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RE: Treatment Rationale for PLA2R-Induced Membranous Nephropathy with back groun Diabetic Nephropathy 16 hours ago
references for Ritux + CYC + steroids for MGN. See prior post ------------------------------ Roger Rodby MD, FASN Professor of Medicine Ru...
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RE: Treatment Rationale for PLA2R-Induced Membranous Nephropathy with back groun Diabetic Nephropathy 17 hours ago
My understanding of the Rituximab with low dose CYC , also includes prednisone, (Niles attached in next post) is to increase the response rate, but...
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RE: Light chain cast nephropathy 17 hours ago
It sounds like he has had this now for at least a month, but despite the obvious diagnosis, I suspect heme will want a bone marrow, and that will t...
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Light chain cast nephropathy 19 hours ago
71 year old Male came to outpatient clinic as a STAT referral for AKI. His Creatinine earlier this year was 0.98. Creatinine up to 4.9. He was volu...
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RE: Treatment Rationale for PLA2R-Induced Membranous Nephropathy with back groun Diabetic Nephropathy 19 hours ago
With the superimposition of Diabetic Nephropathy in this case, urinary protein excretion will be of dubious value fir determining a response to RTX...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 20 hours ago
With this much IFTA I would predict no effect or worsening with a CNI , but this is based on speculation not evidence (or experience ).. B cell dir...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 21 hours ago
just to be clear we have not done CNI on any of our patients yet but that was suggested at one of the discussions I had with Columbia group Here...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 21 hours ago
With LC monotypism, why would you not include this disorder under the umbrella category of MGRS ? Pure speculation. But this disorder seems distinc...
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RE: Treatment Rationale for PLA2R-Induced Membranous Nephropathy with back groun Diabetic Nephropathy 22 hours ago
I dont see how you cannot give him a full course of rituximab. IF the proteinuria was not that high and he did not have DM I should see watching ...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 22 hours ago
articles attached ------------------------------ Roger Rodby MD, FASN Professor of Medicine Rush University Medical Center Chicago I...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 22 hours ago
This fits the Larson ARKANA described patients well, especially the SAP positive staining. "Clinical outcome Treatment and follow-up data...
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Cheer on the fellows competing in the 2024 Fellows-In-Training (FIT) Bowl in San Diego! 23 hours ago
While at Kidney Week, please stop by the ASN Futures Theater in Exhibit Hall, of the San Diego Convention Center on Thursday, October 24, and Frida...
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Cheer on your colleagues at the 2024 Fellows-In-Training (FIT) Bowl in San Diego! 23 hours ago
While at Kidney Week, please stop by the ASN Futures Theater in Exhibit Hall, of the San Diego Convention Center on Thursday, October 24, and Frida...
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RE: Mesangial Proliferative Glomerulonephritis with Masked. IgG-Kappa Deposits,SAP -Positive 1 day ago
Thank you for weighing in. ------------------------------ Dwayne Bergeaux MD Dialysis Clinic, Inc. Crowley LA (337) 788-2864 --------------------...
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RE: Is this inherited glomerulonephritis, and, if so, which? 1 day ago
The inheritance pattern in this patient or her family does not suggest an AD disorder and the genetic testing did not support a COLIVa3/4 mutation....
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