RE: SLE Lupus nephritis Class V 40 seconds ago

1. IF from 2025 still with “Full House”. I will update EM finding when I have the report in front of me again. 2. He developed or manifested LN whi...

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RE: SLE Lupus nephritis Class V 37 minutes ago

Thanks prof glassock for input Non nephrotic our class v what would be your starting therapy ? And if things not improving let’s say 6 month to a...

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RE: SLE Lupus nephritis Class V 42 minutes ago

My goodness- triple therapy for non-nephrotic "pure" Class V Membranous Lupus Nephropathy. I do not think so. Other opinions welcome!! ----------...

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RE: SLE Lupus nephritis Class V 46 minutes ago

I think that Dr. Rodby's suggestions are very reasonable, but not "backed up" by "hard (RCT) evidence (yet). The % global sclerosis is about 2-3 x ...

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RE: SLE Lupus nephritis Class V 1 hour ago

Was patient on mmf 1 g bd before Thanks --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: SLE Lupus nephritis Class V 1 hour ago

Thanks for case Why was volclosporin stopped? Was patient compliant ? Present mmf 1g bd was patient on this dose? Any worsening of extra renal s...

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RE: Denovo Idiopathic MPGN of Renal Allograft 1 hour ago

Yes prof glassock thanks . My question was on hypothesis pronase was negative and diagnosis as combination of rejection and idiopathic Mpgn And ...

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RE: MPO-ANCA Vasculitis 1 hour ago

Thanks for case Creatinine improved Crp improved Urine acr stuck Urine dip active sediment Have you done any repeat lung imaging to see resolu...

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RE: MPO-ANCA Vasculitis 1 hour ago

We have a large experience in completely withdrawing corticosteroids in kidney transplant recipients. Some patients develop severe myalgias/arthral...

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RE: SLE Lupus nephritis Class V 1 hour ago

Since class-V LN developed when the patient was on Benlysta, I wondered if anti-CD20 therapy will be effective in this patient. However, my AI cons...

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RE: SLE Lupus nephritis Class V 2 hours ago

He is on "MMF 1 g BID, losartan 100 mg, eplerenone 25 mg, and empaglifozin 10 mg." that is a lot of medicine I woud give him rituximab 2 gr...

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RE: SLE Lupus nephritis Class V 2 hours ago

Always a problem with "Pure" Class V LN. Proteinuria is a poor indicator of the "activity" of immune complex formation and deposition. The AI and C...

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RE: SLE Lupus nephritis Class V 2 hours ago

8/60 global sclerosis. 0/60 focal sclerosis. EXT II negative --------------------------------- [Sheng] [Kuo] MD, FASN --------------------------...

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RE: SLE Lupus nephritis Class V 2 hours ago

At the time of 2025 biopsy (and also 2021), activity score was 0. I can’t attribute the proteinuria to the chronicity based on the report and he ha...

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RE: SLE Lupus nephritis Class V 2 hours ago

How much, if any, superimposed FSGS lesions were seen in the second Kidney Biopsy in 2025? Was the biopsy stained for EXTI/II? ------------------...

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RE: SLE Lupus nephritis Class V 5 hours ago

He has normal kidney function, no RBC, normal complements , activity score 0, some chronicity , and a very mildly raised dsDNa... Would you conside...

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RE: SLE Lupus nephritis Class V 6 hours ago

Patients with Pure Class V LN were nit included in thexREGENCY trial so we cannot be certain concerning response to OBI. I probably would not chang...

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SLE Lupus nephritis Class V 6 hours ago

40-year-old Chinese male with history of hypertension, Sjogren's syndrome, and SLE complicated by lupus nephritis LN class V came to our practice f...

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RE: MPO-ANCA Vasculitis 7 hours ago

My two cents: Pt is doing well and has responded. I would stop everything and just go with rituxumab 500-1000 q 6 months for maintenance for ma...

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RE: MPO-ANCA Vasculitis 8 hours ago

Thank you so much for reply. No sign of rhabdo, CK is normal (todays value, but no cramps this morning) Last Cyclophosphamide given May 7th, 75...

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RE: MPO-ANCA Vasculitis 9 hours ago

The muscle cramps could be due to steroids or CYC (or both). They will likeky improve over time. Any signs of rhabdomyolysis , Potassium or Magnesi...

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MPO-ANCA Vasculitis 10 hours ago

Input greatly appreciated on following case - MPO-ANCA vasculitis treatment and problem w cramps Caucasian male, 59 yrs old. No comorbidity. D...

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RE: C5 blocker in IgA and other controversial recommendations 14 hours ago

Not sure if this is the right forum, but I would like to know your thoughts on how the prices of these can be taken down to a realistic level. Righ...

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RE: Denovo Idiopathic MPGN of Renal Allograft 21 hours ago

I am not sure that I would use Pegcetacoplan in this case, as it remains unproven that it represents de novo Primary IC-MPGN in a kidney allograft....

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RE: Denovo Idiopathic MPGN of Renal Allograft 21 hours ago

Assuming dual pathology --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: Denovo Idiopathic MPGN of Renal Allograft 21 hours ago

Thanks tac , mmf and steroids pegcetacoplan for ( rejection and idiopathic immune complex Gn ) --------------------------------- Muhammad Soobadar...

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RE: Denovo Idiopathic MPGN of Renal Allograft 22 hours ago

from the rejection ( as I already stated IV high dose steroids already given might have treated TCR - for maintenance IS -Tac +MMF+ low dose steroi...

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RE: C5 blocker in IgA and other controversial recommendations 23 hours ago

Dr. Dastoor. Many thanks for your description of the pharmaceutical prescribing environment in UAE. In many ways, the differences between UAE and t...

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RE: Treatment of progressing Fabrys 1 day ago

Really grateful for this erudite discussion! ------------------------------ Valerie Luyckx MD, MS, PhD Renal Division, Brigham and Women;s Hos...

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RE: Treatment of progressing Fabrys 1 day ago

BP is around 120 systolic but I have ordered a 24h ABPM, if any higher I was planning an ACEI…cardiac MRI is totally normal ---------------------...

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RE: Treatment of progressing Fabrys 1 day ago

Thank you! ------------------------------ Valerie Luyckx MD, MS, PhD Renal Division, Brigham and Women;s Hospital, Boston, MA; Department of Paed...

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RE: Treatment of progressing Fabrys 1 day ago

I am hoping this may be the case ;) ------------------------------ Valerie Luyckx MD, MS, PhD Renal Division, Brigham and Women;s Hospital, Bo...

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RE: C5 blocker in IgA and other controversial recommendations 1 day ago

Dr. Dastoor- thanks for your detailed response- very helpful. Here are somexcomments. 1) you might find a better response to oral systemic ster...

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RE: Denovo Idiopathic MPGN of Renal Allograft 1 day ago

And in this case there is dual pathology and if this is idiopathic Mpgn with rejection what to use to treat ? Tac and steroids and mmf ? -----...

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RE: C5 blocker in IgA and other controversial recommendations 1 day ago

Dr. Dastoor- Your point #1 above, specifically stating that excluding all cost considerations all patients with IgAN (except these with an Oxford...

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RE: Denovo Idiopathic MPGN of Renal Allograft 1 day ago

Thanks for case . Rejection and immune complex gn What induction agents was used in first and second transplant ? Please keep us updated as to out...

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RE: C5 blocker in IgA and other controversial recommendations 1 day ago

I agree- the UAE is ahead of the USA. I suppose, that off-label use of Ravulizumab (like Eculizumab ) could ocurr, but not likely with insurance co...

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RE: Treatment of progressing Fabrys 1 day ago

No elevated BP according to the original post. "Slippery slope" vs "Don't just stand there -do something". A common dilemma (or is it a conundrum! ...

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RE: Treatment of progressing Fabrys 1 day ago

Thanks Dr Glassock, My thoughts on using RASi or SGLT2i are based solely on him being 20 and having progressive glomerular sclerosis already and ...

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RE: C5 blocker in IgA and other controversial recommendations 1 day ago

I have not used ravulizumab in patients with IgA nephropathy. It is not yet FDA-approved for IgA nephropathy in the US. -------------------------...

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RE: C5 blocker in IgA and other controversial recommendations 1 day ago

Thanks Dr. Abdeknour for your nice summary of how you use C inhibitors in your patients with IgAN. Just curious- have you accumulated any experienc...

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RE: C5 blocker in IgA and other controversial recommendations 1 day ago

Dr. Dastoor, thank you for sharing your experience and reasoning so openly. This is a useful discussion as our options expand faster than the compa...

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RE: Treatment of progressing Fabrys 1 day ago

Thanks Dr. Rodby (and Open Evidence) for adding to this already illuminating discussion of progression of renal functional decline and global Glome...

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RE: Treatment of progressing Fabrys 1 day ago

Open evidence: "Does Enzyme replacement therapy prevent progression of CKD in Fabry?" Seems starting at age 10 should have helped more but it may...

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RE: Treatment of progressing Fabrys 1 day ago

Thank you all. I had found the same info that ERT does not prevent ongoing podocyte injury. He has never had any microalbuminuria Sent from my iPh...

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RE: Treatment of progressing Fabrys 1 day ago

Dr. Lerman, the following reference from the AI response is relevant to your question:: https://pmc.ncbi.nlm.nih.gov/articles/PMC10232004/ it a...

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RE: Treatment of progressing Fabrys 1 day ago

Could absence of glomerular hypertrophy & proteinuria reflect converse of Brenner hypothesis (given ׳very tall’, ie height-correlated nephron over-...

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RE: Treatment of progressing Fabrys 2 days ago

Dr. Venkat did your AI suggest any additional treatment? ------------------------------ [Mark] [Lerman] [MD,FASN,FACP,FAST] AST KPCOP EC [Past Me...

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RE: Treatment of progressing Fabrys 2 days ago

Dr. Venkat- many thanks. Hard to postulate progressive podocyte injury in absence of proteinuria (albuminuria ). Could this be a delayed response t...

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RE: Treatment of progressing Fabrys 2 days ago

Thanks for posting this case. I did a Google AI search with the following question: "Findings on serial kidney biopsies in Fabry's patients on cont...

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