RE: Clinical Use of burosumab 58 minutes ago

@Stuart Sprague ------------------------------ Roger Rodby MD, FASN Professor of Medicine Rush University Nephrology Associates Chicago IL (773) ...

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Clinical Use of burosumab 2 hours ago

I am treating my first patient with X-linked hypophosphatemia and after some delay have received authorization to give her burosumab. (anti-FGF23 m...

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RE: Dialysis Core Curriculum 4 hours ago

Thank you for sharing. Looking forward to reviewing this material. ------------------------------ Gurwant Kaur MD FASN Associate Professor of Me...

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Dialysis Core Curriculum 4 hours ago

Dear Nephrology Educators: We wanted to reach out and share a new curricular opportunity that is available in the Dialysis Education space from AS...

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RE: C3GN with lambda light chains 6 hours ago

Thanks for this. I will arrange for AP complement testing. im curious though - are there any tests that will change ultimate course of management...

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RE: interpretation of renal transplant ultrasound 6 hours ago

"urine acr 3" Units? Is it 3 g/g? If heavy albuminuria, given (de novo?) DQ antibody, need to consider transplant glomerulopathy/chronic AMR. N...

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RE: Post-surgical renal cortical necrosis in APS - continue PLEX / eculizumab / IVIG, or de-escalate? 6 hours ago

What are the titers and types of antiphospholipid antibodies ------------------------------ Katafan Achkar MD, FASN Houston Methodist Hospital an...

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RE: Resistant hypertension 7 hours ago

I agree with other comments that further investigation of hematuria/proteinuria are warranted to investigate possible intrinsic renal cause of seco...

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RE: C3GN with lambda light chains 14 hours ago

Thanks a lot --------------------------------- Shahzad Safdar MD Mt. Auburn Nephrology, Inc. Cincinnati OH (513) 841-0222 --------------------...

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RE: C3GN with lambda light chains 15 hours ago

See Jokiranta TS, et al. J Immunol 1999; 163: 4590-4596 for the index case of Lambda monoclonal indirect causation ( via a bifunctional nano body )...

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RE: C3GN with lambda light chains 16 hours ago

Reports that are mostly lambda and seldom kappa. ------------------------------ Richard Glassock MD, FASN Emeritus Professor Geffen School of Med...

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RE: C3GN with lambda light chains 16 hours ago

Dr Glassock thanks have a question Is it only lambda or can Kappa monoclonal chains also interfere with the action of Factor H on C3 Thanks --...

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RE: Resistant hypertension 18 hours ago

Marked hematuria- but no description of erythricyte morphology , Trace albuminuria , but UPCR of 1.9gm/gm or is it mg/micromol? This is not the pat...

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RE: Resistant hypertension 18 hours ago

Definition of resistant hypertension requires that at least one of the agents used be a diuretic, long acting chlorthalidone once daily is preferre...

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RE: Resistant hypertension 20 hours ago

Thanks Dr George. Sorry for bothering you asking for details. You have mentioned active microscopic hematuria with many RBC’s in urine studies. ?d...

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RE: interpretation of renal transplant ultrasound 22 hours ago

What is age of the kidney transplant patient and why was dual kidney transplant performed rather than single kidney transplant? please post the de-...

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RE: vasculitis anca 22 hours ago

When did she restart anti-coagulation? Has eGFR improved despite restarting anticoagulation? , ------------------------------ Richard Glassock M...

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RE: interpretation of renal transplant ultrasound 22 hours ago

Two transplant kidneys are seen in the RIF. Superior kidney measures 8.2cm. Grossly normal appearances of this transplant kidney with no evidence o...

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RE: vasculitis anca 22 hours ago

Absence of fibrocelluar crescent. And only fibrous crescent ( active vs no active Vascultis ) --------------------------------- Muhammad Soobad...

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RE: vasculitis anca 22 hours ago

Many thanks prof glassock and prof lerman I did not pay heed to doac and doac nephropathy However I do not believe that it is associated with cre...

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RE: Post-surgical renal cortical necrosis in APS - continue PLEX / eculizumab / IVIG, or de-escalate? 22 hours ago

All of your Questions are good ones, falling within the realm of clinical judgment, not evidence or guidelines. They are best approached by those w...

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RE: vasculitis anca 1 day ago

Agree with Dr.Glassock -complete biopsy report including EM and IF would make recommendations on treatment and prognosis much less difficult ----...

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RE: vasculitis anca 1 day ago

It would help to know what the urine sediment shows , as acanthocytes and red cell casts would definitely indicate and active Vasculitis , especial...

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RE: vasculitis anca 1 day ago

Thanks I would treat and not rebiopsy and you can inform her oncologist too Bw --------------------------------- Muhammad Soobadar MBChB UK ---...

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interpretation of renal transplant ultrasound 1 day ago

Dual renal tx in 2014 - no prospect for further transplant. gradually deteriorating transplant function Gleeson 8 prostate cancer but not formally ...

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RE: vasculitis anca 1 day ago

her em is pending - not finalized report, and she overall healthy and functional and not frail. htn hld and afib are only active issue. cxr clear,...

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RE: Resistant hypertension 1 day ago

This important to know Drugs that decrease both PRA and aldosterone: Beta-blockers and central alpha-2 agonists suppress both renin and aldost...

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RE: vasculitis anca 1 day ago

If your theory about no active disease was true then steroids would not improve things Also you don’t say how many glomeruli ? My understanding i...

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RE: vasculitis anca 1 day ago

Without avacopan --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: vasculitis anca 1 day ago

Many thanks dr shivangi What is her functional status and cognitive status? I assume no extra renal manifestation You have ruled out cancer with ...

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RE: Steroid-refractory seronegative demyelinating encephalitis in a kidney transplant recipient 1 day ago

Thanks so the addendum refers to the radiologist, changing his interpretation of the MRI? and I suppose the neurologist changing what they believe ...

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Post-surgical renal cortical necrosis in APS - continue PLEX / eculizumab / IVIG, or de-escalate? 1 day ago

Looking for input on de-escalating therapy in a recovering APS-associated renal TMA / cortical necrosis case. Case: 66F with known antiphospholipi...

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RE: 28 year old patient with severe myasthenia/myopathy whose strength significantly improves after dialysis. 1 day ago

Fascinating. Thank you for sharing, Dr. Bleyer and look forward to reading more about this case as you gather further information - it might help u...

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RE: Steroid-refractory seronegative demyelinating encephalitis in a kidney transplant recipient 1 day ago

Motor vehicle collision- the deficit happened when she was driving the MRI referenced in the ID consult was the original imaging from a week a...

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vasculitis anca 1 day ago

Hi, I have patient with 75 yo female with htn hld afib on xarelto, hx of colon can s/p colectomy right, dvt pe with ivc filter2022 all same admissi...

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RE: Steroid-refractory seronegative demyelinating encephalitis in a kidney transplant recipient 1 day ago

Don't disagree with planned brain biopsy if the CNS imaging is now thought to be more consistent with a glioma. A little confused, was the infectio...

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RE: post infective vs C3 glomerulonephritis 1 day ago

In my opinion, the finding of multiple subepithelial hump-like deposits by EM is insufficient to separate IRGN and C3GN. This finding can be observ...

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RE: 28 year old patient with severe myasthenia/myopathy whose strength significantly improves after dialysis. 1 day ago

Thank you all for your answers! WE are exploring the core temperature issue by adjusting temperature at dialysis. Also, we are doing a metabolome b...

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RE: Resistant hypertension 1 day ago

Thanks Dr. Glassock. I offered hospitalization but due to social reasons the patient was unwilling. She claims to be compliant with the meds. --...

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RE: Resistant hypertension 1 day ago

Thanks Dr. Kesavan. Opthalmic evaluation revealed hypertensive Retinopathy with no papilledema. ------------------------------ Jaison George MD,...

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RE: Resistant hypertension 1 day ago

Thanks Dr. Lerman. The tests were done prior to starting ARB, spironolactone and beta blocker. The patient claims to be compliant on drugs, and was...

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RE: Resistant hypertension 1 day ago

Thanks What about urine hypertensive screen to check compliance? Can I ask why would long acting thiazide diuretic be preferred ? Many thanks ...

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RE: post infective vs C3 glomerulonephritis 1 day ago

C4 stain was not done. Having focal proliferative GN not MPGN and Sub epithelial humps on EM is more consistant with PIGN ? ----------------------...

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RE: post infective vs C3 glomerulonephritis 1 day ago

I agree with Drs, Venkat and Lerman the kidney biopsy finding of extensive global and segmental Glomerulosclerosis indicates that this process has ...

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RE: FSGS in patient with CML 1 day ago

The lesion of FSGS is well recognized as a secondary complication of many myeloproliferative disorders, including CML. Dasatinib unfortunately is a...

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RE: post infective vs C3 glomerulonephritis 1 day ago

Were cultures obtained prior to antibiotics? What was the dose of pulse steroids and how many? Biopsy suggest more than an acute process with c...

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FSGS in patient with CML 1 day ago

Patient is a 44-year-old gentleman with a history of CML, gout, hyperlipidemia, and hypertension. Patient on referral was on Dasatnib for his CML. ...

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RE: Resistant hypertension 1 day ago

I agree with Dr. Lerman that compliance is a significant concern. Why not hospitalize and give meds under direct supervision and begin to wean from...

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RE: Resistant hypertension 1 day ago

More clinical data needed Building up of so many anti hypertensive agents covering all families ( except diuretics ), hormonal imaging studies ind...

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RE: post infective vs C3 glomerulonephritis 1 day ago

Would measuring C3NeF be be of any value in separating C3GN from IRGN,? ------------------------------ Richard Glassock MD, FASN Emeritus Profess...

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