RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 1 hour ago

Or - is it the pure opposite: : : : :> a healthy functional "denervated" transplant simply DECOMPRESSES the pressure > (change in glomerular capill...

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RE: Possible IgG4 Or Lymphocytic Hyper eosinophilia Or Mast Cell Disorder 4 hours ago

Dr.Safdar , did you mean to post this under our transplant community since this patient has not had a kidney transplant. You may want to repost in ...

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RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 4 hours ago

Thanks Dr.Venkat -I just reviewed your abstract and briefly scan your article. I noted that all of the patients that you reported decreasing protei...

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Possible IgG4 Or Lymphocytic Hyper eosinophilia Or Mast Cell Disorder 13 hours ago

64 year old male with long-term diabetes, chronic disease stage four, has persistently high eosinophils , high IGE, also has high IgG4 in the range...

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RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 15 hours ago

Nephrotic-o-genic Factor[s] washed out? Some factors that liver don't volunteer to clear, intestines don't eliminate Would wash out with the s...

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RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 21 hours ago

When I posted this case earlier today, I did not remember that I had already posted it in 2023. Please see following link: https://community.asn-...

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RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 23 hours ago

Thank you Dr. Venkat for "resurrecting" a discussion about the mechanism(s) underlying kidney-to-kidney crosstalk talk in human biology. This has b...

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RE: Avacopan 23 hours ago

What happens to the Phase 4 trial if the drug is removed from the market in the USA? Does it covert to a Phase 3? ------------------------------ ...

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RE: Avacopan 23 hours ago

I tend to be leery and reticent to start using agents that have been on the market for less than a year because once it's released to the wide publ...

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Different proteinuria trends following two kidney transplants 3 months apart in the same patient 1 day ago

A patient of ours had strikingly different evolution of proteinuria following two kidney transplants three months apart. I wish to obtain the opini...

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RE: Avacopan 1 day ago

Dear Dr Rogby, if you are doing well, but you learn that you are eating food that can potentially poison you in 1-2 months, would you continue to...

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RE: Avacopan 1 day ago

Currently we are part of the phase 4 trial looking at long term data/safety. Paying very close attention to what happens here in the US. -------...

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Glomcon RADIANT program 1 day ago

Encourage your fellows and early career faculty to apply. GLOMCON Radiant is entering its second year and is now accepting applications! This u...

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RE: Avacopan 1 day ago

It is available in Canada. Still being offered --------------------------------- Bajinder Reen MD Etobicoke ON (905) 453-0821 ------------------...

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RE: Avacopan 1 day ago

It came from industry people involved only verbal. No written confirmation --------------------------------- Bajinder Reen MD Etobicoke ON (905...

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RE: Avacopan 1 day ago

Good question Dr. Rodby. No good answers as there are no other FDA approved Complement inhibitors for ANCA Vasculitis , but several might be consid...

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RE: Avacopan 1 day ago

Interesting - any confirmation of these rumors about restoration of Avacopan availability in Japan ? As of today, Avacopan is still on the shelves ...

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RE: Avacopan 1 day ago

I heard Japanese company has withdrawn it’s application to withdraw the drug --------------------------------- Bajinder Reen MD Etobicoke ON (90...

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RE: Avacopan 1 day ago

I should correct my statements . The EMA has officially recommended revocation of approval for Avacopan, but this action will not become final unti...

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RE: Avacopan 1 day ago

We have frank discussion with patient. Some have chosen to continue most of them stopped --------------------------------- Bajinder Reen MD Etobi...

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RE: Avacopan 1 day ago

We are part of it. It is difficult to trial to enroll. Hopefully will be alternative in fyture --------------------------------- Bajinder Reen MD ...

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RE: Avacopan 1 day ago

The real question I have is what will you do with a patient ON it that seems to be doing well. ------------------------------ Roger Rodby MD, FA...

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RE: Avacopan 1 day ago

Thanks - the Alexion Phase 2 trial (TRANSCEND ) is currently in progress. ------------------------------ Richard Glassock MD, FASN Emeritus Prof...

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RE: Avacopan 2 days ago

May be patient who responded to Avacopan needed low dose anyway without Avacopan. Just curious --------------------------------- Bajinder Reen MD...

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RE: Avacopan 2 days ago

Sadly, I fear it will lead again to more use of steroids. ------------------------------ Jordan Rosenstock MD, FASN New York NY (212) 434-6800 -...

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RE: Avacopan 2 days ago

When Data integrity is breached , it is big issue for me There is phase trial Trascend , may be an option in future -----------------------------...

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Avacopan 2 days ago

Today the European Medicine Agency (EMA) removed Avacopan from the market for therapy of ANCA Vasculitis Japan had done the same lat month. The FDA...

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RE: AI in Kidney Care 2 days ago

Dr. Wynn- Great question. It is importantly that you , and others , understand that Open Evidence, Claude, OpenAI (LLM and Agentuc general purpos...

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RE: AI in Kidney Care 3 days ago

Same. It is a highly effective tool physicians can use to fine tune individualized patient care. Our education & practices continue to evolve....

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RE: AI in Kidney Care 3 days ago

We could probably begin an infinitely long thread on AI in medicine and undergrad and graduate medical educatio There's something new and fascina...

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RE: Recurrent CaPhos stones with low urinary citrate 3 days ago

Thanks for all the detailed clinical information. But I will always ask for more. As noted by Drs Glassock and Lerman, the simplest explanation f...

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RE: AI in Kidney Care 3 days ago

Increasingly, I am using Claude (Anthropic) as well as Expert AI (UpToDate) to make informed responses to Posts on the ASN Open Forum. I find both ...

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RE: Recurrent CaPhos stones with low urinary citrate Wednesday, June 24 @ 1:11 PM

Yes it would be best for her to stop the topirimate especially if you can educate her on the relationship between the drug and her acidosis and sto...

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RE: Recurrent CaPhos stones with low urinary citrate Wednesday, June 24 @ 11:50 AM

Dr. Sawyers- thanks for the additional information, the low citrate excretion might be attributed to Topiramate.. It should be stopped, permanently...

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RE: Recurrent CaPhos stones with low urinary citrate Wednesday, June 24 @ 10:50 AM

Sir, Thank you for taking the time to reply. -Serial creatinines have been 0.89, 1.06, 0.93, 0.97 with concurrent eGFRs of 77, 63, >60, >60,...

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RE: sibeprenlimab Tuesday, June 23 @ 3:04 PM

Good point about complement inhibitors and viral infections. This is a problem will reveal itself when B-cell targeted therapy expands outside SL...

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RE: Recurrent CaPhos stones with low urinary citrate Tuesday, June 23 @ 1:15 PM

Have you considered r/o Sjögren's as the cause of dRTA particularly given the patients systemic symptoms. Unfortunately, even if she does have Sjog...

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RE: Recurrent CaPhos stones with low urinary citrate Tuesday, June 23 @ 10:37 AM

Dr Sawyers, Thanks for the thorough patient history, obviously a challenging case. I do have a few more questions for you: What is her current ...

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AI in Kidney Care Tuesday, June 23 @ 9:38 AM

Nice article in the June Kidney News focused on a study that benchmarks LLMs against human performance. Thank you @Karin Bergling and @Hanjie Zhang...

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RE: Recurrent CaPhos stones with low urinary citrate Monday, June 22 @ 7:06 PM

I am sure that Drs. Asplin or Goldfarb will give a much better answer to your question than mine . I think a real issue exists in the lack ever ach...

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RE: sibeprenlimab Monday, June 22 @ 5:33 PM

We would need to have a detailed description of the patient with IgAN to determine if Iptacopan was indicated in the first place. It seems unlikely...

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Seeking Input for an NSF I-Corps Dialysis Initiative Monday, June 22 @ 2:13 PM

Hello everyone, My name is Ruimin Pan, and I am a Research Scientist at NYU Langone Health. My team and I are participating in the National Scien...

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RE: sibeprenlimab Monday, June 22 @ 11:28 AM

My specific question was prompted by a pt with high titer core and sAb and negative sAg-ie no active infection but definitely with hx of past infec...

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RE: sibeprenlimab Monday, June 22 @ 11:11 AM

In The Phase 2 ENVISION trial, "known chronic infectious disease" was listed among the key exclusion criteria. This included patients with Hepatiti...

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RE: Persistent Indeterminate B-cell Crossmatch Before Living Donor Kidney Transplantation Monday, June 22 @ 9:34 AM

With a negative SAB I don't have anything else to offer except to follow the excellent advice of @Mark Lerman ------------------------------ Sati...

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RE: Persistant metabolic acidosis after cystectomy Monday, June 22 @ 8:40 AM

Thank you very much for your expertise and suggestions. Lactate has been measured repeatedly on blood gas analysis and fluctuates between 1.5 and ...

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RE: Persistent Indeterminate B-cell Crossmatch Before Living Donor Kidney Transplantation Monday, June 22 @ 8:37 AM

Thank you very much for your invaluable comments and expert guidance. As an update, the repeat Single Antigen Bead (SAB) assay remains negative, w...

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RE: Persistent metabolic acidosis after cystectoy Monday, June 22 @ 6:46 AM

The progression of kidney disease can be hastened by metabolic acidosis. Researchers at Tulane University, led by Sixto G. Giusti, MD, conducted a ...

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RE: sibeprenlimab Monday, June 22 @ 2:14 AM

Great question. The FDA approved level for Sibeprenlinab clearly states that patients prescribed this agent should be evaluated for active infectio...

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RE: Persistent metabolic acidosis after cystectoy Sunday, June 21 @ 9:32 PM

Thanks Dr. Lerman for finding this case report I doubt the findings in this case have any clear relevance to the posted case under discussion. If P...

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