RE: Possible IgG4 Or Lymphocytic Hypereosinophilia Or Mast Cell Disorder 2 hours ago

In my opinion- this patient needs a DMSA scan and a kidney biopsy and genetic testing - the clinical picture is chronic interstitial nephritis. ...

View Discussion

RE: Possible IgG4 Or Lymphocytic Hypereosinophilia Or Mast Cell Disorder 4 hours ago

was the biopsy stained for IgG4? need renal details, creatinine , Alb Cr ratio, Prot creat ratio, urinalysis. how high was Eosinophils, anythin...

View Discussion

RE: Possible IgG4 Or Lymphocytic Hypereosinophilia Or Mast Cell Disorder 5 hours ago

As I previously stated when you posted on Transplant forum ( although no transplant in this patient- would get parasitic esp stronglyiides serology...

View Discussion

RE: Possible IgG4 Or Lymphocytic Hypereosinophilia Or Mast Cell Disorder 6 hours ago

Dr. Safdar can you please provide the actual creatinine/eGFR values as well as absolute eosinophil count? Were other parasite serologies were per...

View Discussion

Possible IgG4 Or Lymphocytic Hypereosinophilia Or Mast Cell Disorder 16 hours ago

64 year old male with long-term diabetes, chronic disease stage four, has persistently high eosinophils , high IGE, also has high IgG4 in the range...

View Discussion

RE: Possible IgG4 Or Lymphocytic Hyper eosinophilia Or Mast Cell Disorder 16 hours ago

Dr lerman thanks Yes did not realize got posted in TX forum Will post in open forum Did treat for stromglyoides twice Repeating serology again T...

View Discussion

RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 18 hours ago

Dr. Salman. I agree, but cannot directly prove, that the addition of a fully functioning kidney results in a decrease in glomerular capillary press...

View Discussion

RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 1 day ago

Dr. Lerman: I am not personally aware of studies showing persistence of native kidney proteinuria during DGF or primary non-function of kidney tran...

View Discussion

RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 1 day ago

Or - is it the pure opposite: : : : :> a healthy functional "denervated" transplant simply DECOMPRESSES the pressure > (change in glomerular capill...

View Discussion

RE: Possible IgG4 Or Lymphocytic Hyper eosinophilia Or Mast Cell Disorder 1 day ago

Dr.Safdar , did you mean to post this under our transplant community since this patient has not had a kidney transplant. You may want to repost in ...

View Discussion

RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 1 day ago

Thanks Dr.Venkat -I just reviewed your abstract and briefly scan your article. I noted that all of the patients that you reported decreasing protei...

View Discussion

Possible IgG4 Or Lymphocytic Hyper eosinophilia Or Mast Cell Disorder 1 day ago

64 year old male with long-term diabetes, chronic disease stage four, has persistently high eosinophils , high IGE, also has high IgG4 in the range...

View Discussion

RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 1 day ago

Nephrotic-o-genic Factor[s] washed out? Some factors that liver don't volunteer to clear, intestines don't eliminate Would wash out with the s...

View Discussion

RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 1 day ago

When I posted this case earlier today, I did not remember that I had already posted it in 2023. Please see following link: https://community.asn-...

View Discussion

RE: Different proteinuria trends following two kidney transplants 3 months apart in the same patient 2 days ago

Thank you Dr. Venkat for "resurrecting" a discussion about the mechanism(s) underlying kidney-to-kidney crosstalk talk in human biology. This has b...

View Discussion

RE: Avacopan 2 days ago

What happens to the Phase 4 trial if the drug is removed from the market in the USA? Does it covert to a Phase 3? ------------------------------ ...

View Discussion

RE: Avacopan 2 days ago

I tend to be leery and reticent to start using agents that have been on the market for less than a year because once it's released to the wide publ...

View Discussion

Different proteinuria trends following two kidney transplants 3 months apart in the same patient 2 days ago

A patient of ours had strikingly different evolution of proteinuria following two kidney transplants three months apart. I wish to obtain the opini...

View Discussion

RE: Avacopan 2 days ago

Dear Dr Rogby, if you are doing well, but you learn that you are eating food that can potentially poison you in 1-2 months, would you continue to...

View Discussion

RE: Avacopan 2 days ago

Currently we are part of the phase 4 trial looking at long term data/safety. Paying very close attention to what happens here in the US. -------...

View Discussion

Glomcon RADIANT program 2 days ago

Encourage your fellows and early career faculty to apply. GLOMCON Radiant is entering its second year and is now accepting applications! This u...

View Discussion

RE: Avacopan 3 days ago

It is available in Canada. Still being offered --------------------------------- Bajinder Reen MD Etobicoke ON (905) 453-0821 ------------------...

View Discussion

RE: Avacopan 3 days ago

It came from industry people involved only verbal. No written confirmation --------------------------------- Bajinder Reen MD Etobicoke ON (905...

View Discussion

RE: Avacopan 3 days ago

Good question Dr. Rodby. No good answers as there are no other FDA approved Complement inhibitors for ANCA Vasculitis , but several might be consid...

View Discussion

RE: Avacopan 3 days ago

Interesting - any confirmation of these rumors about restoration of Avacopan availability in Japan ? As of today, Avacopan is still on the shelves ...

View Discussion

RE: Avacopan 3 days ago

I heard Japanese company has withdrawn it’s application to withdraw the drug --------------------------------- Bajinder Reen MD Etobicoke ON (90...

View Discussion

RE: Avacopan 3 days ago

I should correct my statements . The EMA has officially recommended revocation of approval for Avacopan, but this action will not become final unti...

View Discussion

RE: Avacopan 3 days ago

We have frank discussion with patient. Some have chosen to continue most of them stopped --------------------------------- Bajinder Reen MD Etobi...

View Discussion

RE: Avacopan 3 days ago

We are part of it. It is difficult to trial to enroll. Hopefully will be alternative in fyture --------------------------------- Bajinder Reen MD ...

View Discussion

RE: Avacopan 3 days ago

The real question I have is what will you do with a patient ON it that seems to be doing well. ------------------------------ Roger Rodby MD, FA...

View Discussion

RE: Avacopan 3 days ago

Thanks - the Alexion Phase 2 trial (TRANSCEND ) is currently in progress. ------------------------------ Richard Glassock MD, FASN Emeritus Prof...

View Discussion

RE: Avacopan 3 days ago

May be patient who responded to Avacopan needed low dose anyway without Avacopan. Just curious --------------------------------- Bajinder Reen MD...

View Discussion

RE: Avacopan 3 days ago

Sadly, I fear it will lead again to more use of steroids. ------------------------------ Jordan Rosenstock MD, FASN New York NY (212) 434-6800 -...

View Discussion

RE: Avacopan 3 days ago

When Data integrity is breached , it is big issue for me There is phase trial Trascend , may be an option in future -----------------------------...

View Discussion

Avacopan 3 days ago

Today the European Medicine Agency (EMA) removed Avacopan from the market for therapy of ANCA Vasculitis Japan had done the same lat month. The FDA...

View Discussion

RE: AI in Kidney Care Thursday, June 25 @ 3:36 PM

Dr. Wynn- Great question. It is importantly that you , and others , understand that Open Evidence, Claude, OpenAI (LLM and Agentuc general purpos...

View Discussion

RE: AI in Kidney Care Thursday, June 25 @ 8:55 AM

Same. It is a highly effective tool physicians can use to fine tune individualized patient care. Our education & practices continue to evolve....

View Discussion

RE: AI in Kidney Care Thursday, June 25 @ 8:29 AM

We could probably begin an infinitely long thread on AI in medicine and undergrad and graduate medical educatio There's something new and fascina...

View Discussion

RE: Recurrent CaPhos stones with low urinary citrate Wednesday, June 24 @ 5:23 PM

Thanks for all the detailed clinical information. But I will always ask for more. As noted by Drs Glassock and Lerman, the simplest explanation f...

View Discussion

RE: AI in Kidney Care Wednesday, June 24 @ 3:45 PM

Increasingly, I am using Claude (Anthropic) as well as Expert AI (UpToDate) to make informed responses to Posts on the ASN Open Forum. I find both ...

View Discussion

RE: Recurrent CaPhos stones with low urinary citrate Wednesday, June 24 @ 1:11 PM

Yes it would be best for her to stop the topirimate especially if you can educate her on the relationship between the drug and her acidosis and sto...

View Discussion

RE: Recurrent CaPhos stones with low urinary citrate Wednesday, June 24 @ 11:50 AM

Dr. Sawyers- thanks for the additional information, the low citrate excretion might be attributed to Topiramate.. It should be stopped, permanently...

View Discussion

RE: Recurrent CaPhos stones with low urinary citrate Wednesday, June 24 @ 10:50 AM

Sir, Thank you for taking the time to reply. -Serial creatinines have been 0.89, 1.06, 0.93, 0.97 with concurrent eGFRs of 77, 63, >60, >60,...

View Discussion

RE: sibeprenlimab Tuesday, June 23 @ 3:04 PM

Good point about complement inhibitors and viral infections. This is a problem will reveal itself when B-cell targeted therapy expands outside SL...

View Discussion

RE: Recurrent CaPhos stones with low urinary citrate Tuesday, June 23 @ 1:15 PM

Have you considered r/o Sjögren's as the cause of dRTA particularly given the patients systemic symptoms. Unfortunately, even if she does have Sjog...

View Discussion

RE: Recurrent CaPhos stones with low urinary citrate Tuesday, June 23 @ 10:37 AM

Dr Sawyers, Thanks for the thorough patient history, obviously a challenging case. I do have a few more questions for you: What is her current ...

View Discussion

AI in Kidney Care Tuesday, June 23 @ 9:38 AM

Nice article in the June Kidney News focused on a study that benchmarks LLMs against human performance. Thank you @Karin Bergling and @Hanjie Zhang...

View Discussion

RE: Recurrent CaPhos stones with low urinary citrate Monday, June 22 @ 7:06 PM

I am sure that Drs. Asplin or Goldfarb will give a much better answer to your question than mine . I think a real issue exists in the lack ever ach...

View Discussion

RE: sibeprenlimab Monday, June 22 @ 5:33 PM

We would need to have a detailed description of the patient with IgAN to determine if Iptacopan was indicated in the first place. It seems unlikely...

View Discussion

Seeking Input for an NSF I-Corps Dialysis Initiative Monday, June 22 @ 2:13 PM

Hello everyone, My name is Ruimin Pan, and I am a Research Scientist at NYU Langone Health. My team and I are participating in the National Scien...

View Discussion