RE: Hep B Core Positive And Risk Of Liver Cancer 55 minutes ago

According to this study, yes, but this study was done on patients with NAFLD. So does the patient has USG evidence of NAFLD? ---------------------...

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teriparatide and risk of osteosarcoma 2 hours ago

Can i ask everyone's opinion about using teriparatide in some one who had previous radiotherapy to his spine? This is a kidney transplant recipien...

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Hep B Core Positive And Risk Of Liver Cancer 5 hours ago

Quick question a transplant patient with hepatitis B core positive surface antigen negative maintained on Baraclude prophylaxis for long term pat...

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RE: Use of IVIG in ABO incompatible desensitisation protocol 8 hours ago

Dr. Venkat- Many thanks- this answers all of my questions. Caution should be exercised in used of IVIg in sensitized transplant recipients. -----...

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RE: Use of IVIG in ABO incompatible desensitisation protocol 8 hours ago

The following reference is relevant to the question raised by Dr. Glassock. It deals with IVIG desensitization of highly sensitized potential kidne...

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RE: Global sclerosis in a ypung male with IGAN 10 hours ago

Agree. Nothing else to add. ------------------------------ Mario Rubin, M.D. Houston TX (713) 252-5539 ------------------------------

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RE: Global sclerosis in a ypung male with IGAN 10 hours ago

Dr, Venkat. I can only say that obsolescent glomeruli are seen in normal kidney aging which is not a proteinuric phenomenon. The normal aging kidne...

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RE: Use of IVIG in ABO incompatible desensitisation protocol 10 hours ago

Dr. Lerman- thank for this clarification.. Do lots of IVIg vary in terms of their concentration of iso-hemagglutinins or pretty standard Across all...

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RE: Global sclerosis in a ypung male with IGAN 10 hours ago

Drs. Glassock and Rubin: based on your experience, do you think that proteinuria is less (or even lacking) in patients with 'obsolescent' FGGS comp...

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RE: Global sclerosis in a ypung male with IGAN 10 hours ago

Dr. Rubin Thanks for the pic. The “solidified” pattern of global GS is almost always pathological, whereas the “obsolescent “ pattern is seen wit...

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RE: Global sclerosis in a ypung male with IGAN 11 hours ago

The attached reference discusses at length these 2 forms of global glomerulosclerosis and its implications. ------------------------------ Mario R...

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RE: Global sclerosis in a ypung male with IGAN 11 hours ago

For those not familiar with these 2 patterns of global glomerulosclerosis, please see the post from Arkana labs enclosed below. ------------------...

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RE: Global sclerosis in a ypung male with IGAN 13 hours ago

This is a very nice study and the data support the conclusions. % GSG was not included in the Oxford -MEST - C scoring system as it was highly corr...

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RE: Global sclerosis in a ypung male with IGAN 16 hours ago

https://www.nature.com/articles/s41598-020-63366-0.pdf “In conclusion, GSG abnormal for age might be an independent risk factor that should be eva...

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RE: Global sclerosis in a ypung male with IGAN 16 hours ago

One more question following your last post, Dr Glassock In Dapa- ckd there was no run in period with acei/ arb before starting sglt2 inh So if I ac...

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RE: Global sclerosis in a ypung male with IGAN 17 hours ago

Thanks again Dr Glassock for your valuable input, as always -iPhone -24 2021, 18:22, Richard Glassock via American Society of Nephrology /: ...

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RE: Global sclerosis in a ypung male with IGAN 17 hours ago

Thanks, Dr Roger ------------------------------ Ella Koifman-Zeltzer MD Tel-Aviv ------------------------------

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RE: Global sclerosis in a ypung male with IGAN 17 hours ago

Thanks for the clarification. The global glomerulosclerosis is pathological for sure, what is driving it is less well understood. There is always a...

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RE: Global sclerosis in a ypung male with IGAN 17 hours ago

“Can anabolic steroids ( only three short courses during 2 y period) contribute to FGGS?” FSGS ends up in FGGS Anabolic steroids could contribut...

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RE: Global sclerosis in a ypung male with IGAN 17 hours ago

Thanks Dr GlassockGS- I meant FGGS of 7/24 glomeruli And there was one glomeruli with segmental sclerosisSo, yes, both FGGS and FSGs, but the first...

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RE: Use of IVIG in ABO incompatible desensitisation protocol 17 hours ago

Yes but rarely with low dose IVIG 100mgkg/ doi: 10.5500/wjt.v10.i7.19 ------------------------------ [Mark] [Lerman] [MD,FASN,FACP,FAST] AST KPCOP...

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RE: Global sclerosis in a ypung male with IGAN 18 hours ago

Good question.  FSGS but not FGGS is included in the OXFORD -MEST -C system, perhaps because FSGS gave the same information  as FGGS in terms of pr...

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Global sclerosis in a ypung male with IGAN 18 hours ago

I would appreciate your input on a following case. A 29 old male, smoker, seen initially by me at July 2019 with 700 PCR . Scr 0.7 mg%, 3 RBC/HPF. ...

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RE: Xenograft Huge Advance 20 hours ago

Humans are not baboons, and so this may go faster than 7 years. There is a lot of momentum building. The "stay in your own lane" argument against p...

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RE: IgA vasculitis 21 hours ago

Although Dapsone  can be effective in treating the skin manifestations (palpable purpura) of IgA V, there is no current evidence that  suggests a b...

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RE: IgA vasculitis 1 day ago

I think dapsone has strong anti inflammatory and immunosuppressive properties.it does inhibit lysosome prostaglandins and leukotrines and blocks ne...

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RE: Use of IVIG in ABO incompatible desensitisation protocol 1 day ago

Can't Acute hemolysis due to iso-hemagglutinin content of some IVIg preparations occur in non-blood group O recipients undergoing such desensitizin...

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RE: IgA vasculitis 1 day ago

How does Dapsone work for leukocytoclastic vasculitis anyway thanks It is bacteriostatic anti-parasitic, inhibits PABA and folic acid synthesis --...

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RE: Use of IVIG in ABO incompatible desensitisation protocol 1 day ago

Thank you for the advice ------------------------------ Nimish Gupta MD, MBBS Dr. Metro Hospital, Faridabad Noida (965) 405-9906 ----------------...

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RE: Xenograft Huge Advance 1 day ago

Pig to baboon xenotransplantation has been performed for many years without hyperacute rejection. These pigs have undergone several membrane protei...

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RE: Use of IVIG in ABO incompatible desensitisation protocol 1 day ago

Should not matter as anti ABO IgG titers usually decrease with PP/low dose IVIG The content in this comment/discussion is not intended to be medi...

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RE: Isolated Systolic Hypertension 1 day ago

Mancia G, Giannattasio C. Diagnostic and therapeutic problems of isolated systolic hypertension. J Hypertens. 2015 Jan;33(1):33-43. doi: 10.1097/HJ...

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RE: Biopsy in patient with solitary kidney. 1 day ago

Great question Dr Slater.​ ------------------------------ Bikash Chapagain MD Middletown CT (646) 371-3124 ------------------------------

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RE: Biopsy in patient with solitary kidney. 1 day ago

​The patient declined any biopsy(kidney, lung) and agreed to be treated empirically. Her creatinine trended down to 1.5. She was discharged on oral...

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RE: Biopsy in patient with solitary kidney. 1 day ago

​Thanks for your input Dr Whittier. ------------------------------ Bikash Chapagain MD Middletown CT (646) 371-3124 ------------------------------

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RE: Biopsy in patient with solitary kidney. 1 day ago

Neurology did not feel that way Dr Dastoor.​ ------------------------------ Bikash Chapagain MD Middletown CT (646) 371-3124 ---------------------...

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RE: Isolated Systolic Hypertension 1 day ago

Good point Dr. Mellas.  Do you know of any studies looking at Pulse Pressure change with DHP- CCB in elderly patients with isolated  Systolic hyper...

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RE: Isolated Systolic Hypertension 1 day ago

I would caution that these studies are in patients with elevated SBP and DBP. In systolic hypertension, with non compliant major arteries, and an e...

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RE: Biopsy in patient with solitary kidney. 1 day ago

I do not think that we are ever going to know whether transjugular kidney biopsy is safer than percutaneous kidney biopsy in patients with a solita...

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RE: Isolated Systolic Hypertension 1 day ago

Thank you so much Pro. Glassock. I was very busy with many responsibilities regarding COVID-19 pandemic but insist to come back to my lovely and ve...

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RE: Biopsy in patient with solitary kidney. 1 day ago

They are available at our hospital , the idea being by going through a vein any bleeding goes into the vein. The glomeruli yield is very operator d...

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RE: Isolated Systolic Hypertension 1 day ago

Welcome back Dr. Aledan.  We have mussed you! ------------------------------ Richard Glassock MD, FASN Emeritus Professor David Geffen School of M...

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RE: Biopsy in patient with solitary kidney. 2 days ago

Have only read about it , but what about transjugular kidney biopsy --------------------------------- Dr. Hormaz Dastoor Nephrology Consultant Se...

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RE: Isolated Systolic Hypertension 2 days ago

According to these studies, yes. CCB cause maximal pulse pressure reduction similar to ARB compared to other medications. ------------------------...

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RE: Biopsy in patient with solitary kidney. 2 days ago

Dr. Chapagain: Is SCr still unchanged at 1.7 mg? Any change in urinalysis, urine sediment and urine Pr/Cr? Unless these trends are in a favorable d...

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RE: Biopsy in patient with solitary kidney. 2 days ago

Thanks Dr. Whittier for your perspectives on this topic. Your experience and knowledge in this arena are very valuable and highly respected. If a b...

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RE: Biopsy in patient with solitary kidney. 2 days ago

yes, very little data, small case series, but in experienced hands the trend is to try percutaneously.  I've done several myself.  As Dr. Glassock ...

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RE: Sodium Thiosulfate-PICC or Port 2 days ago

what a difference a word makes, I am actually laughing out loud not just "lol", I was wondering about that bc we have talked about this before and ...

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RE: Isolated Systolic Hypertension 2 days ago

The issue is how much of an effect CCB have on large vessel compliance in ISH. Some studies have shown that CCB improve vascular compliance and the...

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RE: Biopsy in patient with solitary kidney. 2 days ago

It is very uncommon- but probably under-reported (for obvious reasons), my guess is about 1:10,000 for patients with two kidneys. I do not know the...

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