RE: resistant c3gn 1 hour ago

IgG subclass and SAP staining, in addition to Pronase digestion and LC staining are definitely indicated . I favor a diagnosis of "concealed " mono...

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RE: resistant c3gn 2 hours ago

IgG subclass staining by IF might help. ------------------------------ Emilio Venturelli MD Scuola di specializzazione in Nefrologia, Università...

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RE: resistant c3gn 3 hours ago

the igg-kappa is only detectable on IFE-spep varies from normal to slight restriction. KL ratio was 1.05 with normal levels of K and L in 2024. JB9...

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RE: resistant c3gn 3 hours ago

Very puzzling case. At this age a PGNMID would be unusual but this is not typical C3GN especially with organized deposits. I am not surprised by th...

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Deadline Extension: ASN Loan Mitigation Program 3 hours ago

Greetings everyone, The application deadline for the ASN Loan Mitigation Program has been extended to Wednesday, August 26. This program wi...

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Deadline Extension: ASN Loan Mitigation Program 3 hours ago

Greetings everyone, The application deadline for the ASN Loan Mitigation Program has been extended to Wednesday, August 26. This program wi...

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resistant c3gn 3 hours ago

Wondering what folks would do with this atypical probable c3GN patient with resistant disease 23 yo female with long history of hematuria and pro...

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Last Week to Apply to Participate in the ASN FIT Bowl at Kidney Week 2026 4 hours ago

Hi All, The deadline to apply for the 2026 FIT Bowl is Friday, August 28, 2026, details below. Join the American Society of Nephrology (ASN) Fel...

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RE: Pd Question. 6 hours ago

Care of the hospitalised patient receiving peritoneal dialysis: Your questions answered Rehab B Albakr https://orcid.org/0000-0002-8760-5728 and Jo...

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RE: ICI induced IgAV 10 hours ago

I would not use CYC in this case. I prefer RTX based on observational studies. No RCT ------------------------------ Richard Glassock MD, FASN Em...

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RE: ICI induced IgAV 13 hours ago

Thanks Dr Rodby, I've waited a week his creatinine now slighty up to 290 from 258 umol/l. Would you consider adding anything now or would you wait ...

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RE: ICI induced IgAV 13 hours ago

Thank you Dr Glassock. I am hesitant on giving rituximab as I'm a bit worried if he develops a reaction he has limited lung reserve (post partial l...

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RE: Pd Question. 1 day ago

Dear Colleagues I totally agree with Dr Bargman and I think to continue with high concentrate solutions for short time mostly get good results e...

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RE: Pd Question. 1 day ago

I can't open the attachment that you sent, but I suspect it is by Chan et al about PD in the ICU "Can PD Take the Pressure?". Many (I'm being diplo...

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RE: anti gbm serology postive with fever and raised inflammatory markers 1 day ago

Thanks . Dr Saja --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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RE: Pd Question 1 day ago

Removing the external cuff is, in general, of some help i. Curing the exit-site infection; however Pseudomonas infection are very difficult to be c...

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RE: Pd Question 1 day ago

No did not remove it. Is it something that needs to be done ? --------------------------------- Muhammad Soobadar MBChB UK ---------------------...

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RE: anti gbm serology postive with fever and raised inflammatory markers 2 days ago

I want to share this update on the management of Anti-GBM; still, we are limited by evidence, and all depends on how early the diagnosis and interv...

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RE: Pd Question 2 days ago

Did you remove the external catheter cuff? ------------------------------ Giovanni Cancarini Nephrologist Brescia, Italy gcancarini@alice.it ----...

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RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 2 days ago

Professor Richard, I agree that we should repeat the biopsy and then decide on the further plan accordingly, especially given the absence of c...

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Pd Question. 2 days ago

https://journals.sagepub.com/doi/10.1177/08968608221125714?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed#core-bibr44-...

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RE: Pd Question 2 days ago

https://pmc.ncbi.nlm.nih.gov/articles/PMC4655795/ --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------

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Pd Question 2 days ago

Dear colleagues , How long to treat pseudomonas exit site infection in pd patient on APD ? I have a patient who pseudomonas ESI resistant to Cipr...

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RE: Pd Question. 2 days ago

Very helpful Paper prof bargman Any colleagues have info/ resource on mesh repair and pd dialysis whether needs holding or not ? Thanks --------...

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RE: Pd Question. 2 days ago

Many thanks prof bargman and prof rodby Case 1 Patient was given 48 hr break post pancreatic biopsy . Drain was bloody but settled down day aft...

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RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 2 days ago

I have a few questions. This patient has had only one kidney biopsy 8 +years ago showing Class III LN. The Anti-DNA has been negative for oast 8 mo...

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RE: anti gbm serology postive with fever and raised inflammatory markers 2 days ago

I agree with the hypothetical scenario, except I would use CYC for another 4-week, plus steroids. Not much evidence for RTX in antiGBM with DAH . ...

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RE: anti gbm serology postive with fever and raised inflammatory markers 2 days ago

Thanks prof glassock the mdt met this afternoon and decided to stop ( personally I would have tried with Atleast 4 weeks of cyclo before calling ...

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RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 2 days ago

Thank you for sharing this challenging case. From my perspective, I would consider this SLE-associated secondary TMA with complement amplificatio...

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RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

With the strong evidence of serological activity of LN , I am not very confident that a repeat biopsy will contribute much to treatment decision ma...

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RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

Almost 4 weeks dialysis dependent and still not anti-GBM negative. The prognosis for recovery of renal function is very poor, but only the treating...

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RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

22nd July dialysis dependent Post plex ( 3rd or 4th anti gbm level >8) --------------------------------- Muhammad Soobadar MBChB UK -----------...

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RE: PR-3 ANCA with lung involvement 3 days ago

The reason i brought up the Rituxvas trial was that they used in the Rituximab arm, IV Cyc day 1 and day 15 .. i thought this was the only rct evid...

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RE: PR-3 ANCA with lung involvement 3 days ago

the CYCLOPS trial compared IV to oral CYC in vasculitis in a RCT. The only differences were a lower cumulative dosage in IV and an increae in relap...

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RE: PR-3 ANCA with lung involvement 3 days ago

Daily oral CYC was the standard for lupus until the NIH started IV CYC monthly infusions for SLE which gained popularity bc of adherence and ease. ...

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RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

Dear Dr. Mohammed, Thank you for your helpful advice. I have also been considering a repeat kidney biopsy and will likely proceed. We will also i...

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RE: Lupus-associated TMA with no response after four weekly doses of eculizumab: withdraw or continue? 3 days ago

Dear Professor Glassock, Thank you so much for your feedback on my case. The patient has not received standard triple therapy because treatment...

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RE: Obstructing Urinary Stone 3 days ago

Glad she has done well! Would have loved to know what creatinine was prior to stone removal. Just regarding our discussion 😁 -------------------...

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RE: PR-3 ANCA with lung involvement 3 days ago

Thank you Prof. Glassock! --------------------------------- Mark Nader MD Germantown TN (201) 805-2000 ---------------------------------

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RE: Obstructing Urinary Stone 3 days ago

Both the patient and myself were concerned about the ill effects of untreated presumed complete unilateral urinary tract obstruction by a stone at ...

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RE: PR-3 ANCA with lung involvement 3 days ago

Oral was the way CYC was delivered in the trial. There pr is no proven advantages of IV over oral CYC in outcome studies of Vasculitis. In a compli...

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RE: Obstructing Urinary Stone 3 days ago

Exactly why an elevated creatinine above baseline in your patient with stone producing unilateral hydronephrosis ( mild to moderate ) on US was con...

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RE: PR-3 ANCA with lung involvement 3 days ago

@Richard Glassock , is there a reason you prefer oral cyclophosphamide in this case as opposed to IV cyc x 2 doses such as in the rituxvas trial? A...

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RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

How long has he been oliguric and requiring dialysis?. Is his antiGBM antibody negative pre-PLEX? ------------------------------ Richard Glassock...

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RE: is it lead poisoning? 3 days ago

This is glomerular proteinuria and a near normal plasmal lead. I do not think that further testing is needed. ------------------------------ Ric...

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RE: is it lead poisoning? 3 days ago

0.11 umol/L <0.1 ------------------------------ Muhammad Soobadar MBChB UK ------------------------------

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RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

@prog glassock do you agree for continuing cyclo and plex for now? ------------------------------ Muhammad Soobadar MBChB UK -------------------...

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RE: anti gbm serology postive with fever and raised inflammatory markers 3 days ago

Timeline 4/08 first dose methlypred and on weaning pred He has finished 9 session of plex on Monday 19/08 first one 5/08 Cyclophosphamide 150 mg ...

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RE: Pd Question. Thursday, August 20 @ 2:57 PM

"I can't really comment about when a mesh is used, but we routinely continue with PD after a hernia repair. We will keep the patient dry for a few ...

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RE: anti gbm serology postive with fever and raised inflammatory markers Thursday, August 20 @ 1:53 PM

May discuss with Pulom team if can go for bronchoscopy and BAL screen for any co-existing infection ------------------------------ Saja Mohammed...

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