ASN represents more than 21,000 kidney health professionals working to help people with kidney diseases and their families. Comprised of all of ASN's focus areas, the ASN Alliance for Kidney Health allows the society to continue its growth and work towards the goal of a world without kidney diseases.
The latest Nephrology Self-Assessment Program (nephSAP) issue, Volume 23: Issue 5 (Dec 2024): Transplantation is now available online.
RE: Urgent: ASN Must Advocate for Dr. Rasha Alawieh's Re-Entry to the U.S 7 hours ago
Well said Joel. With all the happenings in the last few weeks - the silence from leadership at institutions and organizations has been deafening. ...
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Urgent: ASN Must Advocate for Dr. Rasha Alawieh's Re-Entry to the U.S 8 hours ago
Dear Prabir Roy-Chaudhury and the ASN Leadership, I am writing to express deep concern over the case of Dr. Rasha Alawieh, a highly respected 34-y...
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RE: Hypokalaemia 10 hours ago
Urine: chloride <20, uOsm 611, uNa <20, uK 95, uCreat 39.9 Note: U Cl reported as < 20 suggesting the complete absorption of all NaCl which must ...
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RE: Hypokalaemia 14 hours ago
I have another view of this complex and interesting case. A few years of polyuria, nocturia and incontinence may suggest hypokalemia is the main d...
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RE: Relevance Of Ds DNA Positivity With Negative Ana And Normal C3/c4 22 hours ago
Thanks everyone really helpful --------------------------------- Muhammad Soobadar MBChB UK ---------------------------------
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RE: Relevance Of Ds DNA Positivity With Negative Ana And Normal C3/c4 1 day ago
That's an astute thought Dr Salman. There does seem to be cross reactivity between antibodies to bacterial dsDNA and calf thymus dsDNA. The latter ...
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RE: Relevance Of Ds DNA Positivity With Negative Ana And Normal C3/c4 1 day ago
Do bacteria have double stranded DNA? " Yes, bacteria, like other organisms, utilize double-stranded DNA (dsDNA) as their genetic material, typi...
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RE: Relevance Of Ds DNA Positivity With Negative Ana And Normal C3/c4 1 day ago
This is endocarditis related gn with autoimmune markers until proven otherwise, did you by chance get a Rheumatoid factor? It is not false positive...
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RE: Relevance Of Ds DNA Positivity With Negative Ana And Normal C3/c4 1 day ago
I think she has TINU or Behçet's Dz triggered by a serious infection + endocarditis. It appears that broken DS-DNA particles exposed by the injur...
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RE: Hypokalaemia 2 days ago
Urine: chloride <20, uOsm 611, uNa <20, uK 95, uCreat 39.9 Renin/aldosterone ratio 48 and 61 The low U Na and K and elevated U som needs o be exp...
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RE: Hyponatremia 2 days ago
As Dr Rodby said about NSAIDs (a million takers, almost no hyponatremia), the same could probably be said about RASIs and thirst. Her low GFR wil...
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RE: Relevance Of Ds DNA Positivity With Negative Ana And Normal C3/c4 2 days ago
Anti- ds DNA antibodies (as well as ANCA and very rarely antiGBM antibodies) can be observed in infective endocarditis. They usually disappear with...
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RE: Hyponatremia 2 days ago
I assume she has no DM and her RBS is normal as hyperglycemia can cause thirst. If Hyponatremia was due to NSAIDs, it may be associated with hyper...
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RE: Relevance Of Ds DNA Positivity With Negative Ana And Normal C3/c4 2 days ago
I will try to learn the American Way of writing dates . Sorry for inconvenience Best wishes --------------------------------- Muhammad Soobadar ...
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RE: Hypokalaemia 2 days ago
Urine osmolal gap is almost 400 if one considers that average dipstick glucose of 2+ translates into a glucose concentration of around 10 mmol/L. C...
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Relevance Of Ds DNA Positivity With Negative Ana And Normal C3/c4 2 days ago
65 female Bg: CCF, Cellulitis, Hypothyroid , Obesity , Anxiety , IDA Admitted with urosepsis , right eye anterior uveitis , oral thrush and low...
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RE: Hyponatremia 2 days ago
So, average SIADH exacerbated by polydipsia. If this is not NSAIA related (Im very skeptical on that, "everybody" takes NSAIAs) If you have ...
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RE: Hypokalaemia 2 days ago
Could I offer another possibility...surreptitious use of diuretics? I find it unusual that a RTA would associate with a non-low (and perhaps mild...
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RE: Hyponatremia 2 days ago
Thank you for all your replys. Her serum uric acid is 4.6 mg/dl. renal function is reduced with eGFR of 55 ml/min, was attributed to RAASi and ...
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RE: Hypokalaemia 3 days ago
Excellent - thanks all. ------------------------------ Dr Adam Rumjon MBBS MRCP London ------------------------------
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RE: Hypokalaemia 3 days ago
Urinary K wasting and glycosuria with a nl serum glucose, proximal tubular disease (partial fanconi) I have seen this with HIV drugs , specifi...
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RE: Hyponatremia 3 days ago
" The U Na of 120 (120 x 2 = 240) does not allow for U K or other U osmoles suggesting the actual U osm should be much higher than 240." Good po...
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RE: Hyponatremia 3 days ago
serum osmolality 265 urine osmolality 240 urine Na 120 Is suspicious for a chronic SIADH with the concentrated urine. The U Na of 120 (120 x ...
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RE: Hypokalaemia 3 days ago
…the units of the UACR are mg/mmoL. --------------------------------- Dr Adam Rumjon MBBS MRCP London ---------------------------------
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RE: Hypokalaemia 3 days ago
Thank you very much. The phosphate level was within the normal range, 1 mmol/L. Thank you - yes I should send a urinary RBP and B2M. -----------...
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RE: Hypokalaemia 3 days ago
Looks like possible proximal tubule dysfunction (? Lamuvidine). Can you obtain a urinary Beta2 microglobulin or retinol binding globulin in the uri...
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Hypokalaemia 3 days ago
I was wondering whether I might be able to pick your collective brains. I can't quite work out why this woman has a low potassium... She was refe...
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RE: Hyponatremia 3 days ago
What is the serum urea. . The urine findings suggest low urea excretion, maybe Hyponatremia is due to low solute (urea) excretion. , but tge excess...
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RE: Hyponatremia 3 days ago
Case studies have been reported showing association between NSAIDS and hyponatremia. -According to UpToDate: Hyponatremia — NSAIDs diminish the ...
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RE: Hyponatremia 3 days ago
NSAIDs and hyponatremia ( euvolemic hyponatremia ) has rarely been reported. Usually Ibuprofen. what was uric acid? What was NsAID ? https://d...
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Hyponatremia 3 days ago
55 year old lady with background of hypertension on Coveram and metoprolol, had recent total knee replacement surgery and maintained on NSAIDs, pre...
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RE: Gross hematuria in a pregnant patient 3 days ago
Thanks, Dr. Alhosaini. ------------------------------ K.K. Venkat MD Troy MI (248) 420 7798 ------------------------------
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RE: Hypokalemia and hyperparathyroidism 3 days ago
Thank you all for your thoughts. I will do genetic study for Bartters and Gitelmans syndrome ------------------------------ Wael Jebur MD, FA...
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RE: Gross hematuria in a pregnant patient 3 days ago
My understanding from article 2 is that electrophoresis showed high beta globulin in all samples with different degrees of urine osmolality, this i...
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RE: Nephrotic range proteinuria associated with cGVHD Wednesday, March 12 @ 6:32 PM
As Dr. Rodby stated, FSGS is not common in SCT patients. This seems to me like a secondary FSGS with the normal Salb and glomerulomegaly. Is he obe...
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RE: IF negative anti-GBM Wednesday, March 12 @ 11:45 AM
Thanks Dr. Fogo. I agree that PLA2R + MN with superimposed crescentic GN due to aGBM and ANCA is a consideration. The totally negative IgG and the ...
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RE: Gross hematuria in a pregnant patient Wednesday, March 12 @ 10:58 AM
@Mohamad Alhosaini: Regarding the use of UAlb/Cr, UPr/Cr and urine protein electrophoresis to differentiate non-glomerular from glomerular bleeding...
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RE: IF negative anti-GBM Wednesday, March 12 @ 10:03 AM
Anti-GBM antibody disease and membranous nephropathy can coexist -it is thought that one injury can unmasked cryptic epitopes and play a part in tr...
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RE: IF negative anti-GBM Wednesday, March 12 @ 9:30 AM
"She was started on haemodialysis due to oligoanuria within days of presentation and remains dialysis dependent although improving urine output." ...
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RE: IF negative anti-GBM Wednesday, March 12 @ 4:29 AM
Thank you. The antiGBM has been repeated multiple times and after PLEX - the lowest has been 500 (there are two tests pending). They are runnin...
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RE: Nephrotic range proteinuria associated with cGVHD Wednesday, March 12 @ 3:38 AM
Dr.Venkat's suggestion is a very good one. If the patient has been on a CNI for a long time to suppress GVHD, then a secondary form of FSGS due to ...
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RE: Gross hematuria in a pregnant patient Wednesday, March 12 @ 3:36 AM
Thank you Dr. Venkat, very nice articles, of note the urine electrophoresis showed spike in beta globulin fraction and the albumin seemed to be oka...
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RE: IF negative anti-GBM Tuesday, March 11 @ 10:28 PM
Too bad no EM. False negative IF for IgG very uncommon in anti-GBM disease. . Something is very fishy about this case. What assay was used for anti...
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RE: Nephrotic range proteinuria associated with cGVHD Tuesday, March 11 @ 10:16 PM
Was cyclosporine or tacrolimus used post-stem cell transplant/GVHD? If yes, for how long? Besides GVHD itself, chronic CNI-related afferent arterio...
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RE: IF negative anti-GBM Tuesday, March 11 @ 9:18 PM
. ------------------------------ Victoria Sasongko MBBS FRACP Nephrologist Lismore Base Hospital Lismore, NSW Australia -------------------------...
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RE: IF negative anti-GBM Tuesday, March 11 @ 7:44 PM
What does 2+ 'membranous granular " mean? Can you post the de-identified pathology report.? ------------------------------ Richard Glassock MD, F...
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RE: Nephrotic range proteinuria associated with cGVHD Tuesday, March 11 @ 7:38 PM
Any Family History of kidney disease. I think I might do genetic testing. Any features by IF that suggest anti-nephrin auto-antibody. If so, I migh...
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RE: Nephrotic range proteinuria associated with cGVHD Tuesday, March 11 @ 7:12 PM
Thank you for your answer. This is not TMA or MGN. I believe it is FSGS. eGFR by Cistatin C is 40 mL/min. uProt. is in the 3 g/day range. pro...
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RE: Gross hematuria in a pregnant patient Tuesday, March 11 @ 5:37 PM
@K.K. Venkat Thank you ------------------------------ Mario Rubin, M.D. Houston TX (713) 252-5539 ------------------------------
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IF negative anti-GBM Tuesday, March 11 @ 5:14 PM
Hi everyone, Presenting a case of a 65yo F, background AF, diabetes, bronchiectasis and hypothyroidism presented with RPGN (Cr normal > 500umol/L...
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