RE: ADPKD ON JYNARQUE 4 hours ago

Really interesting conversation about SGL2Is and ADPKD and mechanisms--thanks to all-- and the proof will be in the pudding, when the relevant stud...

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RE: ADPKD ON JYNARQUE 5 hours ago

6.Kapoor S, Rodriguez D, Riwanto M et al. Effect of sodium-glucose cotransport inhibition on polycystic kidney disease progression in PCK rats. PLo...

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RE: ADPKD ON JYNARQUE 5 hours ago

7.Morioka F, Nakatani S, Uedono H et al. Short-term dapagliflozin administration in autosomal dominant polycystic kidney disease-a retrospective si...

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RE: ADPKD ON JYNARQUE 6 hours ago

I am not sure this has been established in human patients with ADPKD who are also on RASi. Can you cite any supporting literature for this statemen...

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RE: Hypocalcemia And Hypoparathyroidism 7 hours ago

Thanks will do Very helpful --------------------------------- Shahzad Safdar MD Mt. Auburn Nephrology, Inc. Cincinnati OH (513) 841-0222 ----...

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RE: ADPKD ON JYNARQUE 7 hours ago

Thanks But if pt not on Tolvaptan SGLTI will cause high vasopressin which will cause increase expansion of Cysts -------------------------------...

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RE: ADPKD ON JYNARQUE 8 hours ago

My point was if decreased renal mass led to increased SNGFR and Glomerular HTN as part of the progressive nature of ADPKD, I would have predicted t...

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RE: ADPKD ON JYNARQUE 8 hours ago

Thanks Dr. Rodby for arguing that SGLT2i have no physiological basis for being "renoprotective" in ADPKD. A counterargument is that as cysts expand...

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RE: ADPKD ON JYNARQUE 9 hours ago

ADPKD is a genetically programmed tubular disease RAASi : ACEI and ARB work by lowering (ostensibly) predominantly by lowering glomerular capill...

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RE: ADPKD ON JYNARQUE 10 hours ago

Until the knowledge gap is filled by well designed RCT this issue will remain as a conundrum for physicians and patients alike. See the excellent r...

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RE: Hypocalcemia And Hypoparathyroidism 11 hours ago

Dr Edward Brown at the Brigham has described activating antibodies against the calcium sensing receptor in a variety of conditions causing hypopara...

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RE: Unknown left pleural effusion 12 hours ago

I am not a radiologist, but the path of the catheter seems to me to be more of a subclavian than IJ insertion site. Maybe a lateral Chest x-Ray wou...

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RE: Unknown left pleural effusion 13 hours ago

The tunneled catheter was inserted in the left internal jugular vein, october 2024, chest x ray on april 2025 was normal, all the symptoms started ...

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RE: Unknown left pleural effusion 14 hours ago

Totally agree. Not clear why the Subclavian rather than IJ was chosen. Had the TIJ and LIJ been compromised before? Or was this just a "bad" inadve...

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RE: Multi-center Study - Kidney Transplant for Oxalate Nephropathy 15 hours ago

How many patients with PHO have you done ?What is 1 and 3 yr graft survival? ------------------------------ [Mark] [Lerman] [MD,FASN,FACP,FAST] A...

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RE: Hypocalcemia And Hypoparathyroidism 1 day ago

Thanks Dr Glassock Regyanti-Cytokine antibodies characteristic of auto- immune poly-glandular syndrome Type 1 (Il-22 ,etc) I did not I thought t...

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RE: ADPKD ON JYNARQUE 1 day ago

Thanks Dr Glassock I think KDIGO still did not recommend --------------------------------- Shahzad Safdar MD Mt. Auburn Nephrology, Inc. Cincin...

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RE: IgA Kappa PGMID and EGPA 1 day ago

This thread reminds me of the difficulty in unequivocally establishing monoclonality of Ig depidits.using frozen IF and anti-Kappa and Anti-Lambda ...

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RE: ADPKD ON JYNARQUE 1 day ago

A recent crossover study from Japan showed benefit on eGFR-Creat-CystC in patients with ADPKD already treated with high dose Tolvaptan.( See Uchiya...

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RE: Hypocalcemia And Hypoparathyroidism 1 day ago

Very interesting case. Dis you examine the profile of anti-Cytokine antibodies characteristic of auto- immune poly-glandular syndrome Type 1 (Il-22...

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Hypocalcemia And Hypoparathyroidism 1 day ago

49-year-old female with history of partial colectomy 2006 due to diverticulitis 18 inches of colon removed possible sero negative Rheumatoid arthri...

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RE: Autosomal dominant Tubulointerstitial Kidney Disease 1 day ago

Do canadian patients are eligible If yes I will enroll two patients --------------------------------- Bajinder Reen MD Etobicoke ON (905) 453-0...

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ADPKD ON JYNARQUE 1 day ago

I have a patient who is 43 years of age with ADPKD with creatinine 2 GFR 42. Proteiniris 254 mg is there any role for SGL2 inhibitor with his condi...

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RE: Autosomal dominant Tubulointerstitial Kidney Disease 1 day ago

I also have a quite newly discovered patient with HNF-beta1 mutation. Do you also include such patient into your registry? I have referred the pati...

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RE: IgA Kappa PGMID and EGPA 1 day ago

I arrived at a 16-gage needle because unless there was significant loss of glomerular density (Fibrosis) ,one good pass was all that was needed. I ...

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RE: IgA Kappa PGMID and EGPA 1 day ago

That's a good questions. There is also the issue of over submission to IF and EM at the expense of LM even when the biopsy is adequate. --------...

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RE: IgA Kappa PGMID and EGPA 1 day ago

I will also add that radiologist here at UCLA are also excellent (with on-site adequacy). They use 18 g and we rarely have inadequate specimens. Th...

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RE: IgA Kappa PGMID and EGPA 1 day ago

I do not think there is fixed choice. Institution choice affect. In our group we use 18g which has internal diameter of 0.838 mm (say 0.8). The 16g...

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RE: IgA Kappa PGMID and EGPA 1 day ago

I believe that your statement, "And I am sure in some situations each pass is just dropped into each fixative vial without any though" may be all t...

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RE: Unknown left pleural effusion 1 day ago

The catheter appears to be inserted in the left subclavian or even the lt brachiocephalic vein (and not the right IJ). This is very likely catheter...

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RE: IgA Kappa PGMID and EGPA 1 day ago

I by trial and error determined that the 16 g needle was the proper choice when the automatic "guns " were introduced. I have no idea what gauge is...

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Multi-center Study - Kidney Transplant for Oxalate Nephropathy 1 day ago

Hello, I am a kidney transplant surgeon at the University of Minnesota. We are looking to put together a multi-center retrospective study of pat...

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RE: IgA Kappa PGMID and EGPA 1 day ago

This is center dependent. Ideally there is on-site adequacy at the beside where a pathologist, technician, or other personnel from pathology (or ra...

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RE: IgA Kappa PGMID and EGPA 1 day ago

Based on my reading of the literature and recommendations I have heard from others is that 16g needle is the recommended gauge to balance safety an...

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RE: IgA Kappa PGMID and EGPA 2 days ago

thank you for the references. I loved the Vims Silverman needle because the cores were larger and a good pass gave an adequate core that was enough...

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RE: IgA Kappa PGMID and EGPA 2 days ago

I agree that reduction in the inner diameter of the biopsy may contribute to the relative inadequacy of Bx tissue. I have been out of clinical medi...

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RE: ? Cryoglobulinemic GN 2 days ago

Doesn't look like fibrillary or immunotactoid or any other named organized deposition process to me. ------------------------------ Jonathan Zuc...

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RE: ? Cryoglobulinemic GN 2 days ago

Agree that there is some vague organization to the deposits that doesn't seem to resolve as microtubules at high mag. I would also suggest cryo be ...

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RE: IgA Kappa PGMID and EGPA 2 days ago

Here is an interesting study regarding on-site adequacy effect which demonstrated improved diagnostic material and an interesting study from Arkana...

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RE: IgA Kappa PGMID and EGPA 2 days ago

Science and Health Care should have no borders. Welcome to an organization dedicated to improving both world-wide. ------------------------------...

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RE: IgA Kappa PGMID and EGPA 2 days ago

Welcome to Canada. Glad to have you on our side --------------------------------- Bajinder Reen MD Etobicoke ON (905) 453-0821 -----------------...

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RE: Autosomal dominant Tubulointerstitial Kidney Disease 2 days ago

Dr Bleyer thanks a lot I have 37-year-old single gentleman with HNF1B Gene: HNF1B, Kidney-Associated Disease(s): HNF1B-Related Disor-ders, Inheri...

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RE: IgA Kappa PGMID and EGPA 2 days ago

I remember carrying my Medical School Microscope to assess the adequacy of the Bx specimen. I hated to get a repot stating "medulla only". The diss...

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RE: Unknown left pleural effusion 2 days ago

forgot to attach articles this seems to be not rare but I have never seen it, The literature totally supports venous blockage as the cause of ...

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RE: Unknown left pleural effusion 2 days ago

This seems to be related to a central venous stenosis according to the several articles I am attaching, in each case they removed the catheter and ...

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RE: Autosomal dominant Tubulointerstitial Kidney Disease 2 days ago

the good thing is it is never too late! we are always available to help with this. Thanks! Tony ------------------------------ Anthony Bleye...

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RE: IgA Kappa PGMID and EGPA 2 days ago

I agree with Dr. Zuckerman on all his points! In the past, we had the additional tool of the "Hevylite" antibody staining for IgA-kappa and IgA-l...

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Unknown left pleural effusion 2 days ago

A 58-year-old ESKD female on HD via a right internal jugular tunneled catheter, in february 2025 a native AVF brachiocephalic was performed, with p...

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RE: Autosomal dominant Tubulointerstitial Kidney Disease 2 days ago

@Anthony Bleyer This is a big deal thanks. I did not know that Natera Renasite, our go to gene panel was not able to make a MUC-1 diagnosis. ...

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RE: ? Cryoglobulinemic GN 2 days ago

These EM deposits seem organized to me, not obvious microtubules but not typical "bland" electron dense deposits either. @Jonathan Zuckerman @L...

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