Basic/Clinical Science Session

A Closer Look at Claudins and Their Role in Mineral Disturbances

November 09, 2019 | 02:00 PM - 04:00 PM

Location: 145, Walter E. Washington Convention Center

Session Description

Claudins are tight-junction membrane proteins that function as both pores and barriers in the paracellular pathway in epithelial cells. In kidney, claudins determine the permeability and selectivity of different nephron segments along the renal tubule. In the proximal tubule, claudins have a role in the bulk reabsorption of salt and water. In the thick ascending limb, claudins are important for the reabsorption of calcium and magnesium and are tightly regulated by the calcium-sensing receptor. This session discusses interesting new concepts of claudin-mediated transport in the distal nephron.

Learning Objective(s)

  • Explain the role of claudins in mineral reabsorption
  • Discuss clinical phenotype as a consequence of claudin deficiencies

Learning Pathway(s)

  • Bone and Mineral Metabolism
  • Cell and Transport Physiology


  • Olivier Bonny, MD, PhD
  • Joost Hoenderop, PhD