Basic/Clinical Science Session
The Right Tools for the Job: Model Systems for Glomerular Disease
November 09, 2019 | 02:00 PM - 04:00 PM
Location: Salon C, Walter E. Washington Convention Center
Session Description
A limitation in therapeutic drug development for glomerulopathies is the absence of clinically relevant platforms for modeling human disease pathogenesis. Advances in regenerative biology, stem cell medicine, and engineering have improved the prospects for more accurate disease modeling as well as medium- and high-throughput drug screening assays. This session reviews the latest developments in the application of pluripotent stem cell, organoid, zebrafish, and Drosophila technology to modeling proteinuric kidney disease.
Learning Objective(s)
- Describe the derivation of functional podocytes from induced pluripotent stem cells and the role in modeling human podocytopathies
- Describe the application of microfluidic organ-on-a-chip technology to modeling human glomerular disease
- Identify strengths and limitations of zebrafish and Drosophila for glomerular disease modeling and drug screening
- Describe approaches to modeling progenitor cell reprogramming to replace depleted podocytes during disease pathogenesis
Learning Pathway(s)
- Glomerular Diseases
Moderators
- Puneet Garg, MD, FASN
- John S. Poulton, PhD
Presentations
-
The Glomerulus on a Chip: A New System to Study Podocyte Diseases
02:00 PM - 02:30 PM
Laura Perin, PhD
-
Functional Podocytes from Human Induced Pluripotent Stem Cells and Kidney Disease Modeling
02:30 PM - 03:00 PM
Samira Musah, PhD
-
Zebrafish Modeling of Human Glomerular Disease
03:00 PM - 03:30 PM
Nicole Endlich, PhD
-
Drosophila Nephrocytes to Study Glomerular Disease
03:30 PM - 04:00 PM
Zhe Han, PhD
