Basic/Clinical Science Session

The Right Tools for the Job: Model Systems for Glomerular Disease

November 09, 2019 | 02:00 PM - 04:00 PM

Location: Salon C, Walter E. Washington Convention Center

Session Description

A limitation in therapeutic drug development for glomerulopathies is the absence of clinically relevant platforms for modeling human disease pathogenesis. Advances in regenerative biology, stem cell medicine, and engineering have improved the prospects for more accurate disease modeling as well as medium- and high-throughput drug screening assays. This session reviews the latest developments in the application of pluripotent stem cell, organoid, zebrafish, and Drosophila technology to modeling proteinuric kidney disease.

Learning Objective(s)

  • Describe the derivation of functional podocytes from induced pluripotent stem cells and the role in modeling human podocytopathies
  • Describe the application of microfluidic organ-on-a-chip technology to modeling human glomerular disease
  • Identify strengths and limitations of zebrafish and Drosophila for glomerular disease modeling and drug screening
  • Describe approaches to modeling progenitor cell reprogramming to replace depleted podocytes during disease pathogenesis

Learning Pathway(s)

  • Glomerular Diseases

Moderators

  • Puneet Garg, MD, FASN
  • John S. Poulton, PhD

Presentations