Translational Session

Uromodulin: An Enigmatic Protein Still in Search of a Function

November 07, 2019 | 02:00 PM - 04:00 PM

Location: 144, Walter E. Washington Convention Center

Session Description

Uromodulin is the most abundant urinary protein in humans. Recent progress has been made in unraveling its functions and significance. This session provides an overview of uromodulin’s physiology and involvement in kidney diseases.

Learning Objective(s)

  • Describe the implications of genetics of uromodulin levels
  • Discuss uromodulin expression and its implication for hypertension and kidney diseases
  • Explain serum uromodulin as a risk factor for coronary artery disease, CKD progression, mortality, and graft failure
  • Describe the immune modulatory role of uromodulin in disease

Learning Pathway(s)

  • Chronic Kidney Disease
  • Cell and Transport Physiology


  • Alessia Fornoni, MD, PhD, FASN
  • Luca Musante, PhD


  • The Genetics of Uromodulin
    02:00 PM - 02:30 PM
    Anna Kottgen, MD, MPH
  • An Overview of Uromodulin in Kidney Diseases and Its Regulation of Tubular Function
    02:30 PM - 03:00 PM
    Eric Gregory Olinger, MD
  • Serum Uromodulin as a Potential Marker of Prognosis
    03:00 PM - 03:30 PM
    Dominik Steubl, MD
  • The Immune Modulatory Role of Uromodulin in AKI
    03:30 PM - 04:00 PM
    Tarek M. El-Achkar, MD, FASN