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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

New Biology of Intercalated Cells: Beyond Basic Acid Handling

November 07, 2019 | 02:00 PM - 04:00 PM

Location: 146 C, Walter E. Washington Convention Center

Session Description

Intercalated cells of the distal renal tubule are traditionally viewed as functioning primarily in the regulation of acid-base handling by the kidney. Recent findings indicate that intercalated cells have a surprisingly broad range of roles. This session provides an integrated view of the roles of intercalated cells in electrolyte transport and inflammation and highlights novel regulatory pathways, including circulating hormones, purinergic agonists, transient receptor potential (TRP) channels, and protein kinases.

Learning Objective(s)

  • Explain how WNK kinases integrate multiple intercalated cell transport functions
  • Discuss the acute hormonal regulation of base secretion by secretin
  • Describe the mechanosensory regulation of the H-K-ATPase
  • Discuss the role of intercalated cells in transducing inflammatory signals

Learning Pathway(s)

  • Cell and Transport Physiology


  • Nuria M. Pastor-Soler, MD, PhD, FASN
  • Susan M. Wall, MD


  • WNK4 Regulation of Intercalated Cell Function
    02:00 PM - 02:30 PM
    Régine Chambrey, PhD
  • Hormonal Regulation of Bicarbonate Secretion in Beta Intercalated Cells
    02:30 PM - 03:00 PM
    Jens G. Leipziger, MD, DrMed 
  • TRPV4 and Tubular Flow Regulation of the H+/K+-ATPase
    03:00 PM - 03:30 PM
    Oleh Pochynyuk, PhD 
  • The P2Y14 Receptor: Linking the Intercalated Cell to Immune Defense
    03:30 PM - 04:00 PM
    Sylvie Breton, MS, PhD