Basic/Clinical Science Session

New Biology of Intercalated Cells: Beyond Basic Acid Handling

November 07, 2019 | 02:00 PM - 04:00 PM

Location: 146 C, Walter E. Washington Convention Center

Session Description

Intercalated cells of the distal renal tubule are traditionally viewed as functioning primarily in the regulation of acid-base handling by the kidney. Recent findings indicate that intercalated cells have a surprisingly broad range of roles. This session provides an integrated view of the roles of intercalated cells in electrolyte transport and inflammation and highlights novel regulatory pathways, including circulating hormones, purinergic agonists, transient receptor potential (TRP) channels, and protein kinases.

Learning Objective(s)

  • Explain how WNK kinases integrate multiple intercalated cell transport functions
  • Discuss the acute hormonal regulation of base secretion by secretin
  • Describe the mechanosensory regulation of the H-K-ATPase
  • Discuss the role of intercalated cells in transducing inflammatory signals

Learning Pathway(s)

  • Cell and Transport Physiology

Moderator(s)

  • Nuria M. Pastor-Soler, MD, PhD, FASN
  • Susan M. Wall, MD

Presentations