ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Clinical Practice Session

Drilling Down on Acute Interstitial Nephritis

November 08, 2019 | 10:30 AM - 12:30 PM

Location: Ballroom B, Walter E. Washington Convention Center

Session Description

Acute interstitial nephritis (AIN) remains an important cause of kidney injury. Changing epidemiology is bolstered by new information about potential genetic risks for drug-induced AIN, and immune checkpoint modification by drugs may provide new information about AIN. Drugs, IgG4, and other diseases are important causes of AIN that clinicians must recognize while diagnosis and treatment remain a challenge. Serum and urine studies have been disappointing, but T-cell derived urinary biomarkers may provide new hope. Treatment of AIN with steroids has mixed results and may be targeting the wrong inflammatory pathway.

Learning Objective(s)

  • Describe the epidemiology and risk factors for AIN
  • Discuss the various causes of AIN, including drugs and systemic diseases
  • Describe the limitations of current diagnostic tests for AIN and the potential of new biomarkers
  • Explain the data behind the treatment of AIN with steroids

Learning Pathway(s)

  • Acute Kidney Injury
  • Chronic Kidney Disease


  • Mandana Rastegar, MD
  • Umut Selamet, MD, FASN


  • A Closer Look at the Epidemiology and Risk Factors for Acute Interstitial Nephritis
    10:30 AM - 11:00 AM
    Mohamed G. Atta, MD, MPH, FASN 
  • Diagnosing Acute Interstitial Nephritis: Urine Eosinophils, Urine Sediment, and Novel Biomarkers
    11:00 AM - 11:30 AM
    Dennis G. Moledina, MD, PhD 
  • The Many Faces of Acute Interstitial Nephritis: Drugs, IgG4, and Other Diseases - The Pathologist's View
    11:30 AM - 12:00 PM
    Lynn D. Cornell, MD 
  • Treatment of Acute Interstitial Nephritis: Do Steroids Work or Are We Off Target?
    12:00 PM - 12:30 PM
    Ladan Zand, MD