Clinical Practice Session

Drilling Down on Acute Interstitial Nephritis

November 08, 2019 | 10:30 AM - 12:30 PM

Location: Ballroom B, Walter E. Washington Convention Center

Session Description

Acute interstitial nephritis (AIN) remains an important cause of kidney injury. Changing epidemiology is bolstered by new information about potential genetic risks for drug-induced AIN, and immune checkpoint modification by drugs may provide new information about AIN. Drugs, IgG4, and other diseases are important causes of AIN that clinicians must recognize while diagnosis and treatment remain a challenge. Serum and urine studies have been disappointing, but T-cell derived urinary biomarkers may provide new hope. Treatment of AIN with steroids has mixed results and may be targeting the wrong inflammatory pathway.

Learning Objective(s)

  • Describe the epidemiology and risk factors for AIN
  • Discuss the various causes of AIN, including drugs and systemic diseases
  • Describe the limitations of current diagnostic tests for AIN and the potential of new biomarkers
  • Explain the data behind the treatment of AIN with steroids

Learning Pathway(s)

  • Acute Kidney Injury
  • Chronic Kidney Disease


  • Mandana Rastegar, MD
  • Umut Selamet, MD, FASN