Basic/Clinical Science Session

Glomerular and Tubular Origins of Albuminuria

November 07, 2019 | 10:30 AM - 12:30 PM

Location: 146 C, Walter E. Washington Convention Center

Session Description

Although glomerular injury is the major cause of albuminuria, recent findings suggest novel pathophysiologic mechanisms. This session highlights the contrasting roles of podocyte dysfunction and the rate of tubular endocytosis of albumin in contributing to protein excretion and the surprising roles of tubule transport proteins in the podocyte.

Learning Objective(s)

  • Identify novel pathophysiologic mechanisms in proteinuric kidney disease
  • Discuss the recent understanding of albumin uptake in the proximal tubule
  • Describe a potential role for SGLT2 inhibitors in ameliorating glomerular proteinuria

Learning Pathway(s)

  • Cell and Transport Physiology
  • Glomerular Diseases

Moderators

  • Janos Peti-Peterdi, MD, PhD
  • Nirupama Ramkumar, MD, MPH, FASN

Presentations

  • Podocyte-Specific KLF15 Expression Attenuates Renal Injury in Proteinuric Kidney Disease
    10:30 AM - 11:00 AM
    Sandeep K. Mallipattu, MD, FASN
  • Non-Proximal Tubule Effects of SGLT2 Inhibitors
    11:00 AM - 11:30 AM
    Carlamaria Zoja, PhD 
  • Imaging Approaches to Quantify Proximal Tubule Protein Endocytosis
    11:30 AM - 12:00 PM
    Andrew Hall, MD, PhD
  • The Fate of Tubular Albumin in Proteinuric Disorders
    12:00 PM - 12:30 PM
    Ora A. Weisz, PhD