Basic/Clinical Science Session

New Regulatory Concepts for the Calcium-Sensing Receptor

November 08, 2019 | 02:00 PM - 04:00 PM

Location: 145, Walter E. Washington Convention Center

Session Description

The discovery of the G protein-coupled, calcium-sensing receptor (CaSR) and diseases caused by CaSR mutations provided unquestionable evidence for the critical role of CaSR in the maintenance of systemic mineral homeostasis. The importance of CaSR for these calcitropic processes is highlighted by loss-of-function and gain-of-function CaSR mutations that cause familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia. This session discusses new concepts of regulation and treatment options.

Learning Objective(s)

  • Describe the function of the CaSR and treatment options for patients with CaSR mutations
  • Discuss new regulatory concepts in mineral and electrolyte balance

Learning Pathway(s)

  • Bone and Mineral Metabolism
  • Cell and Transport Physiology


  • Donald T, Ward, PhD
  • Myles Wolf, MD