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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

New Regulatory Concepts for the Calcium-Sensing Receptor

November 08, 2019 | 02:00 PM - 04:00 PM

Location: 145, Walter E. Washington Convention Center

Session Description

The discovery of the G protein-coupled, calcium-sensing receptor (CaSR) and diseases caused by CaSR mutations provided unquestionable evidence for the critical role of CaSR in the maintenance of systemic mineral homeostasis. The importance of CaSR for these calcitropic processes is highlighted by loss-of-function and gain-of-function CaSR mutations that cause familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia. This session discusses new concepts of regulation and treatment options.

Learning Objective(s)

  • Describe the function of the CaSR and treatment options for patients with CaSR mutations
  • Discuss new regulatory concepts in mineral and electrolyte balance

Learning Pathway(s)

  • Bone and Mineral Metabolism
  • Cell and Transport Physiology


  • Donald T, Ward, PhD
  • Myles Wolf, MD


  • The Calcium-Sensing Receptor: Physiology and Diseases
    02:00 PM - 02:30 PM
    Fadil Hannan, MBChB, PhD 
  • Application of Therapeutics Targeting the Calcium-Sensing Receptor to Bone and Parathyroid Diseases
    02:30 PM - 03:00 PM
    Dolores Shoback, MD 
  • The Calcium-Sensing Reception Increases Activity of the Renal NCC Through the WNK4-SPAK Pathway
    03:00 PM - 03:30 PM
    Gerardo Gamba, MD, PhD 
  • The Excretion of Uromodulin Is Modulated by the Calcium-Sensing Receptor
    03:30 PM - 04:00 PM
    Olivier Devuyst, MD, PhD