ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

AKI Repair, Nonrecovery, and Transition to CKD

November 07, 2019 | 02:00 PM - 04:00 PM

Location: Ballroom B, Walter E. Washington Convention Center

Session Description

AKI and CKD are increasingly recognized as mutually reinforcing each other, resulting in poor outcomes for patients. Recent publications have elucidated mechanisms of maladaptive repair from AKI, particularly cell cycle arrest and the primary role of the proximal tubule in initiating tubulointerstitial fibrosis. Novel methodologies have been used to understand the molecular underpinnings of this integrated syndrome. This session discusses the emerging literature on mechanisms of recovery, repair, and transition to CKD after AKI.

Learning Objective(s)

  • Describe leading and emerging research in the molecular mechanisms in transition of AKI to CKD
  • Explain the role of proximal tubular injury in the development of kidney fibrosis
  • Discuss the mechanisms of adaptive and maladaptive repair after AKI
  • Discuss hemodynamic mechanisms in the development of CKD after AKI

Learning Pathway(s)

  • Acute Kidney Injury
  • Chronic Kidney Disease


  • Zheng Dong, PhD, FASN
  • Kelly A. Hyndman, PhD


  • Molecular Characterization of AKI to CKD Transition
    02:00 PM - 02:30 PM
    Sanjeev Kumar, MD, MBBS, PhD
  • Proximal Tubular Signaling in AKI and CKD
    02:30 PM - 03:00 PM
    Leslie S. Gewin, MD 
  • Epithelial Cell Plasticity in Repair from AKI
    03:00 PM - 03:30 PM
    Benjamin D. Humphreys, MD, PhD, FASN
  • Hemodynamic Mechanisms of Progression from AKI to CKD
    03:30 PM - 04:00 PM
    Aaron J. Polichnowski, PhD