Educational Symposium

NRF2 Pathway: Why Is It Important in Kidney Diseases?

November 09, 2019 | 12:45 PM - 01:45 PM

Location: Marquis Ballroom, Salon 5, Marriott Marquis

Session Description

Oxidative stress is defined as an imbalance between the production of free radicals and reactive metabolites and their elimination through protective mechanisms that include antioxidants. This imbalance leads to the damage of cells and important biomolecules, thereby creating a potential adverse impact on the whole organism.

At the center of the day-to-day biological response to oxidative stress is the nuclear factor erythroid 2–related factor 2 (NRF2) pathway. This pathway regulates the transcription of several antioxidant genes that preserve cellular homeostasis and detoxification genes that process and eliminate carcinogens and toxins before they can cause damage.

The signaling system NRF2 is sensitive to the reduction-oxidation reaction and plays a key role in the maintenance of cellular homeostasis under stress. Because NRF2 affects inflammatory, carcinogenic, and pro-apoptotic conditions, it merits consideration as a pharmacological target. This symposium reviews and discusses the recent advancements in the regulation of the NRF2 system and its role under physiological and pathophysiological conditions such as CKD.

Support is provided by an educational grant from Reata Pharmaceuticals.

Learning Objective(s)

  • Describe NRF2 in metabolism and inflammation
  • Discuss NRF2 as a potential therapeutic target in kidney disease

Learning Pathway(s)

  • Chronic Kidney Disease

Moderator

  • Bruce A. Molitoris, MD, FASN

Presentations

  • Introduction
    12:45 PM - 12:55 PM
    Bruce A. Molitoris, MD, FASN
  • Role of NRF2 in Health and CKD: What's New?
    12:55 PM - 01:15 PM
    Peter Stenvinkel, MD, PhD, FASN 
  • NRF2 as a Therapeutic Target in CKD
    01:15 PM - 01:35 PM
    Pablo E. Pergola, MD, PhD
  • Questions and Answers
    01:35 PM - 01:45 PM