Anemia of CKD: A Changing Perspective Based on the HIF Pathway
Anemia of CKD represents a significant burden in the US. "Anemia of CKD: A Changing Perspective Based on the HIF Pathway" discusses the evolution of science for anemia of CKD, beyond ESAs and iron, to the latest advances in science. Anemia of CKD is no longer perceived to be only an EPO and iron deficiency. The activation of the HIF pathway in response to low oxygen levels in the kidney initiates a cascade of events that stimulates physiologic erythropoiesis, with increased EPO production and reduced hepcidin levels. The activation of this pathway is disrupted in patients with anemia of CKD.