Anemia of CKD: A Changing Perspective Based on the HIF Pathway
Anemia of CKD represents a significant burden in the US. "Anemia of CKD: A Changing Perspective Based on the HIF Pathway" discusses the evolution of science for anemia of CKD, beyond ESAs and iron, to the latest advances in science. Anemia of CKD is no longer perceived to be only an EPO and iron deficiency. The activation of the HIF pathway in response to low oxygen levels in the kidney initiates a cascade of events that stimulates physiologic erythropoiesis, with increased EPO production and reduced hepcidin levels. The activation of this pathway is disrupted in patients with anemia of CKD.
Jay Wish, MD is Professor of Clinical Medicine at Indiana University School of Medicine in Indianapolis. He is also Chief Medical Officer of Dialysis Programs at IU Health and Medical Director at DaVita Dialysis Centers in Indianapolis and Muncie. He earned his medical degree from Tufts University School of Medicine, where he was a clinical and research fellow in Nephrology and Chief Medical Resident. He is board certified in Nephrology. Dr Wish is Vice-Chairman of the Editorial Advisory Board for Nephrology News and Issues, and serves on the Editorial Board of the Journal of the American Society of Nephrology and Clinical Journal of the American Society of Nephrology. He has published over 100 research articles, reviews, book chapters, and editorials. He has lectured extensively at national and international meetings. A Fellow of the American College of Physicians and of the American Society of Nephrology, Dr Wish is Past-President of the National Forum of ESRD Networks.
