Reversal of Kidney Diseases: Lessons from Diabetic and Nondiabetic Renal Injury
October 24, 2020 | 02:30 PM - 04:30 PM
Click an icon below to load this item into your calendar. Please note that times are exported as Coordinated Universal Time (UTC). Time zone help.
Basic/Clinical Science Session
Reversal of Kidney Diseases: Lessons from Diabetic and Nondiabetic Renal Injury
October 24, 2020 | 02:30 PM - 04:30 PM
Location: Live-Streamed
Session Description
Diabetic kidney disease is a major health burden for patients with diabetes. Recent discoveries of multiple reno-protective drugs will enable us to slow progressive renal decline and delay onset of ESKD. However, it is becoming more apparent that therapeutic goals should be to stop progressive renal decline and, if possible, restore renal function. In this session, experts in clinical and experimental research present possibilities and limitations in accomplishing such goals.
Learning Objective(s)
- Describe human model of reversal of diabetic structural kidney lesions with regards to pancreas transplant
- Describe human model of reversal of functional impairment of renal function with regards to bariatric surgery
- Discuss results in animal models that showed short-term regression of glomerulosclerosis is possible but it does not persist during longer observation
- Explain the cellular and molecular mechanisms of the novel macula densa cell-mediated glomerular tissue remodeling process and its alterations in diabetes
Learning Pathway(s)
- Diabetes and Metabolism
- Chronic Kidney Disease
Moderators
- Charles E. Alpers, MD
- M. Luiza A. Caramori, MD, MS, PhD
Presentations
- Pancreas Transplantation in Type 1 Diabetes: A Human Model of Reversal of Diabetic Renal Lesions
02:30 PM - 03:00 PM
Michael Mauer, MD
Pancreas Transplantation in Type 1 Diabetes: A Human Model of Reversal of Diabetic Renal Lesions
October 24, 2020 | 02:30 PM - 03:00 PM
Click an icon below to load this item into your calendar. Please note that times are exported as Coordinated Universal Time (UTC). Time zone help.
- Bariatric Surgery: Emerging Therapy to Reverse Kidney Diseases in Severe Obesity
03:00 PM - 03:30 PM
Petter Bjornstad, MD
Petter Bjornstad, MD
Dr. Bjornstad is a NIH, JDRF, CDC, and Boettcher Foundation funded clinician-scientist focused on the neurohormonal, hemodynamic, metabolic, and molecular mechanisms underlying the development of early kidney disease in youth and adults with type 1 and 2 diabetes. He is the Co-Chair of the Renal Working Group of the NIH funded Treatment Options for Type 2 Diabetes in Adolescents & Youth (TODAY) study and an investigator of Kidney Precision Medicine Project (KPMP). More recently, Dr. Bjornstad's group has focused on examining the effects of bariatric surgery on kidney disease in severely obese adolescents and adults with and without type 2 diabetes in the multicenter studies Teen–Longitudinal Assessment of Bariatric Surgery (Teen-LABS) and LABS. Dr. Bjornstad will discuss findings from TODAY, Teen-LABS and LABS, as well as ongoing efforts to understand the mechanisms explaining the nephroprotection afforded by metabolic bariatric surgery.
Bariatric Surgery: Emerging Therapy to Reverse Kidney Diseases in Severe Obesity
October 24, 2020 | 03:00 PM - 03:30 PM
Click an icon below to load this item into your calendar. Please note that times are exported as Coordinated Universal Time (UTC). Time zone help.
- Can We Reverse Diabetic Kidney Disease? Potential and Limitations
03:30 PM - 04:00 PM
Agnes B. Fogo, MD
Agnes B. Fogo, MD
Agnes Fogo holds the John L.Shapiro endowed chair in the Department of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center, with secondary appointments in the departments of Medicine and Pediatrics. She directs the Renal Pathology/Electron Microscopy laboratory. Her research is funded by NIDDK.
Can We Reverse Diabetic Kidney Disease? Potential and Limitations
October 24, 2020 | 03:30 PM - 04:00 PM
Click an icon below to load this item into your calendar. Please note that times are exported as Coordinated Universal Time (UTC). Time zone help.
- Beyond Hemodynamics: Macula Densa Cells Orchestrate Glomerular Tissue Remodeling and Repair
04:00 PM - 04:30 PM
Janos Peti-Peterdi, MD, PhD
Janos Peti-Peterdi, MD, PhD
Janos Peti-Peterdi is professor at the Departments of Physiology and Neuroscience, and Medicine at the University of Southern California. He received his MD (1994) and PhD (1998) degrees from the Semmelweis University Medical School, Budapest, Hungary, and postdoctoral training in renal physiology/nephrology at the University of Alabama at Birmingham (1997-2001). He joined the faculty at USC Keck School of Medicine in 2004, where he received tenure (2007). Dr. Peti-Peterdi is dedicated to finding a cure for chronic kidney disease by performing basic science research in kidney and cardiovascular pathophysiology and clinical and therapeutic translation to mechanism-based new treatments. His laboratory pioneered several applications of intravital multiphoton microscopy to quantitatively visualize dynamic alterations in kidney and nephron structure and function over time during disease processes, including the fate and function of chief renal cell types in endogenous tissue remodeling and regeneration. Dr. Peti-Peterdi’s active research program is funded by the NIH, AHA, ADA, and the LRA. Dr. Peti-Peterdi is member of the American Society for Clinical Investigation, European Academy of Sciences and Arts, American Physiological Society Renal Section, American and International Society of Nephrology, and the American Heart Association’s Hypertension and Kidney in Cardiovascular Disease Councils.
Beyond Hemodynamics: Macula Densa Cells Orchestrate Glomerular Tissue Remodeling and Repair
October 24, 2020 | 04:00 PM - 04:30 PM
Click an icon below to load this item into your calendar. Please note that times are exported as Coordinated Universal Time (UTC). Time zone help.
