Kidney Week

Basic/Clinical Science Session

Reversal of Kidney Diseases: Lessons from Diabetic and Nondiabetic Renal Injury

October 24, 2020 | 02:30 PM - 04:30 PM

Location: Live-Streamed

Session Description

Diabetic kidney disease is a major health burden for patients with diabetes. Recent discoveries of multiple reno-protective drugs will enable us to slow progressive renal decline and delay onset of ESKD. However, it is becoming more apparent that therapeutic goals should be to stop progressive renal decline and, if possible, restore renal function. In this session, experts in clinical and experimental research present possibilities and limitations in accomplishing such goals.

Learning Objective(s)

• Describe human model of reversal of diabetic structural kidney lesions with regards to pancreas transplant
• Describe human model of reversal of functional impairment of renal function with regards to bariatric surgery
• Discuss results in animal models that showed short-term regression of glomerulosclerosis is possible but it does not persist during longer observation
• Explain the cellular and molecular mechanisms of the novel macula densa cell-mediated glomerular tissue remodeling process and its alterations in diabetes

Learning Pathway(s)

• Diabetes and Metabolism
• Chronic Kidney Disease

Moderators

• Charles E. Alpers, MD
• M. Luiza A. Caramori, MD, MS, PhD

Presentations

• Pancreas Transplantation in Type 1 Diabetes: A Human Model of Reversal of Diabetic Renal Lesions
  02:30 PM - 03:00 PM
  Michael Mauer, MD
  

  Michael Mauer, MD

Pancreas Transplantation in Type 1 Diabetes: A Human Model of Reversal of Diabetic Renal Lesions

October 24, 2020 | 02:30 PM - 03:00 PM

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• Bariatric Surgery: Emerging Therapy to Reverse Kidney Diseases in Severe Obesity
  03:00 PM - 03:30 PM
  Petter Bjornstad, MD 
  
  

  Petter Bjornstad, MD

Bariatric Surgery: Emerging Therapy to Reverse Kidney Diseases in Severe Obesity

October 24, 2020 | 03:00 PM - 03:30 PM

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• Can We Reverse Diabetic Kidney Disease? Potential and Limitations
  03:30 PM - 04:00 PM
  Agnes B. Fogo, MD
  

  Agnes B. Fogo, MD

Can We Reverse Diabetic Kidney Disease? Potential and Limitations

October 24, 2020 | 03:30 PM - 04:00 PM

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• Beyond Hemodynamics: Macula Densa Cells Orchestrate Glomerular Tissue Remodeling and Repair
  04:00 PM - 04:30 PM
  Janos Peti-Peterdi, MD, PhD 
  
  

  Janos Peti-Peterdi, MD, PhD

  Janos Peti-Peterdi is professor at the Departments of Physiology and Neuroscience, and Medicine at the University of Southern California. He received his MD (1994) and PhD (1998) degrees from the Semmelweis University Medical School, Budapest, Hungary, and postdoctoral training in renal physiology/nephrology at the University of Alabama at Birmingham (1997-2001). He joined the faculty at USC Keck School of Medicine in 2004, where he received tenure (2007). Dr. Peti-Peterdi is dedicated to finding a cure for chronic kidney disease by performing basic science research in kidney and cardiovascular pathophysiology and clinical and therapeutic translation to mechanism-based new treatments. His laboratory pioneered several applications of intravital multiphoton microscopy to quantitatively visualize dynamic alterations in kidney and nephron structure and function over time during disease processes, including the fate and function of chief renal cell types in endogenous tissue remodeling and regeneration. Dr. Peti-Peterdi’s active research program is funded by the NIH, AHA, ADA, and the LRA. Dr. Peti-Peterdi is member of the American Society for Clinical Investigation, European Academy of Sciences and Arts, American Physiological Society Renal Section, American and International Society of Nephrology, and the American Heart Association’s Hypertension and Kidney in Cardiovascular Disease Councils.

Beyond Hemodynamics: Macula Densa Cells Orchestrate Glomerular Tissue Remodeling and Repair

October 24, 2020 | 04:00 PM - 04:30 PM

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