ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Circulating MicroRNAs as Biomarkers and Therapeutic Targets in Diabetic Kidney Disease

October 22, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

New knowledge is needed to understand mechanisms and to develop new interventions against diabetic kidney disease. Recent discoveries about the biology of microRNAs and their role in kidney pathology provide the basis to consider circulating microRNAs as biomarkers of progressive renal decline in diabetes. Specific microRNAs strongly associated with progressive renal decline can also become possible therapeutic targets to prevent or delay ESKD. In this session, experts in experimental and clinical research discuss the possibilities and limitations in accomplishing such goals.

Learning Objective(s)

  • Identify circulating microRNAs as a novel means of cell-to-cell communication and regulation in normal physiology and disease
  • Explain how quantifying microRNA profiles in urine and in circulation can be used to predict progressive renal decline in patients with diabetes
  • List the ways to prioritize microRNA as therapeutic targets for progressive renal decline in diabetes
  • Discuss recent technologies that enable the development of therapies for microRNA targets

Learning Pathway(s)

  • Diabetes and Metabolism
  • Chronic Kidney Disease


  • Rama Natarajan, PhD, FASN
  • Marcus G. Pezzolesi, PhD, MPH


  • Exosomal MicroRNAs as Novel Modes of Intertissue Communication
    10:00 AM - 10:30 AM
    Ronald Kahn, MD
  • Urinary MicroRNAs in Diabetic Kidney Disease: Biomarkers, Disease Mediators, and Therapeutic Targets
    10:30 AM - 11:00 AM
    Timothy Bowen, PhD 
  • Profiles of Circulating MicroRNAs Associated with Risk of ESKD in Diabetes
    11:00 AM - 11:30 AM
    Andrzej S. Krolewski, MD, PhD
  • Can MicroRNAs Be Targeted Therapeutically to Treat Diabetic Kidney Disease?
    11:30 AM - 12:00 PM
    Jeremy Stuart Duffield, MD, MBChB, PhD