Advanced Systems to Maintain Mineral Balance
October 24, 2020 | 02:30 PM - 04:30 PM
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Basic/Clinical Science Session
Advanced Systems to Maintain Mineral Balance
October 24, 2020 | 02:30 PM - 04:30 PM
Location: Simulive
Session Description
Calcium, phosphate, and magnesium are multivalent cations that are important for many biologic and cellular functions. The kidneys play a central role in the homeostasis of these electrolytes. When body stores of these ions decline significantly, gastrointestinal absorption, bone resorption, and renal tubular reabsorption increase to normalize their levels. This session discusses new mechanistic concepts in how calcium, phosphate, and magnesium are handled by the kidneys.
Learning Objective(s)
- Describe calcium homeostasis in tubular cells
- Characterize phosphate transport in the proximal tubule
- List the causes of renal hypomagnesemia
- Discuss mechanisms of magnesium homeostasis and the interplay of kidney and intestine
Learning Pathway(s)
- Bone and Mineral Metabolism
- Cell and Transport Physiology
Moderators
- Chou-Long Huang, MD, PhD
- Rukshana Shroff, MD, PhD
Presentations
- Phosphate Acts Directly on the Calcium-Sensing Receptor to Stimulate Parathyroid Hormone Secretion
02:30 PM - 03:00 PM
Donald T, Ward, PhD
Donald T, Ward, PhD
Dr Ward is a Reader in the Faculty of Biology, Medicine and Health at The University of Manchester, UK. He first started
working on the calcium-sensing receptor (CaSR) as a postdoc at Harvard Medical School and then as a Kidney Research UK (KRUK) Research Fellow. His principal interest is in the mechanism and control of parathyroid hormone (PTH) secretion by the CaSR and how CaSR function can be modulated by multiple extracellular and intracellular signals.
Phosphate Acts Directly on the Calcium-Sensing Receptor to Stimulate Parathyroid Hormone Secretion
October 24, 2020 | 02:30 PM - 03:00 PM
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- Npt2a Inhibition Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function
03:00 PM - 03:30 PM
Jessica Dominguez Rieg, PhD
Jessica Dominguez Rieg, PhD
Npt2a Inhibition Reduces Plasma Phosphate in Mice with Normal and Reduced Kidney Function
October 24, 2020 | 03:00 PM - 03:30 PM
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- Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability
03:30 PM - 04:00 PM
Karl P. Schlingmann, MD
Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability
October 24, 2020 | 03:30 PM - 04:00 PM
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- Epithelial Magnesium Transport by TRPM6 and TRPM7 in Kidney and Intestine
04:00 PM - 04:30 PM
Vladimir Chubanov, PhD
Epithelial Magnesium Transport by TRPM6 and TRPM7 in Kidney and Intestine
October 24, 2020 | 04:00 PM - 04:30 PM
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