Cannabinoids and Kidney Diseases
October 25, 2020 | 10:00 AM - 12:00 PM
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Basic/Clinical Science Session
Cannabinoids and Kidney Diseases
October 25, 2020 | 10:00 AM - 12:00 PM
Location: On-Demand
Session Description
This session examines the role of the endocannabinoid system in normal kidney physiology and how alterations of this system using exogenous receptor ligands, including tetrahydrocannabinol (THC) and cannabidiol (CBD), is associated with pathological changes in acute and chronic kidney disease. In addition, the latest clinical data regarding the association of cannabis and cannabinoid use with renal and cardiovascular outcomes are reviewed. The potential utility of exogenous cannabinoids and the endocannabinoid system as a target for therapy in kidney diseases are discussed.
Learning Objective(s)
- Describe the role of endo- and exocannabinoids in normal renal physiology
- Summarize the experimental data on the potential role of cannabinoids and endocannabinoid system in pathogenesis of AKI and CKD
- Outline the available clinical data on the association of cannabis and cannabinoid use with kidney disease-related outcomes
- Discuss the potential utility of cannabinoids as a target for therapy in AKI, CKD, and ESRD
Learning Pathway(s)
- Chronic Kidney Disease
- Acute Kidney Injury
Moderators
- Denyse Thornley-Brown, MD
- Christina M. Wyatt, MD
Presentations
- Role of the Endocannabinoid System and Its Ligands in Normal Renal Physiology
10:00 AM - 10:30 AM
Frank Park, PhD
Frank Park, PhD
Frank Park is currently an Associate Professor in the Department of Pharmaceutical Sciences at the University of Tennessee Health Sciences Center in Memphis. He received his Ph.D. (1998) in the Department of Physiology at the Medical College of Wisconsin. His research is focused on G-protein regulation through the actions by G-protein coupled receptors and non-canonical accessory proteins and their impact on kidney function in various states of kidney injury and disease. A major interest of his lab over the past 5 years has been to elucidate the biological role of cannabinoid type 2 receptors in the kidney and determine whether this receptor can be a therapeutic target for the treatment of various forms of acute kidney injury (AKI).
Role of the Endocannabinoid System and Its Ligands in Normal Renal Physiology
October 25, 2020 | 10:00 AM - 10:30 AM
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- A Nephrologist's Guide to Cannabis and Cannabinoids
10:30 AM - 11:00 AM
Joshua L. Rein, DO, FASN
Joshua L. Rein, DO, FASN
Joshua Rein, DO, FASN is a nephrologist, certified hypertension specialist, and an Instructor of Medicine in the Division of Nephrology at the Icahn School of Medicine at Mount Sinai in New York. He is passionate for renal physiology and with the emerging popularity of recreational and medical cannabis in the United States and worldwide, he naturally became interested in its effect on kidney function. As a renal physiologist, his primary research focuses on exploring the role of the kidney endocannabinoid system in regulating electrolyte and acid/base homeostasis. He also studies the risks, benefits, and clinical implications of cannabis consumption among people living with kidney disease, which have been summarized in influential published reviews and at national presentations.
A Nephrologist's Guide to Cannabis and Cannabinoids
October 25, 2020 | 10:30 AM - 11:00 AM
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- Association of Cannabis and Cannabinoid Use with Outcomes in Kidney Diseases and ESRD
11:00 AM - 11:30 AM
Csaba P. Kovesdy, MD, FASN
Csaba P. Kovesdy, MD, FASN
Csaba P. Kovesdy, MD, is The Fred Hatch Professor of Medicine in Nephrology and Director of the Clinical Outcomes and Clinical Trials Program at the University of Tennessee Health Science Center in Memphis, Tennessee and Chief of Nephrology at the Memphis VA Medical Center in Memphis, Tennessee. Dr. Kovesdy earned his medical degree from the University of Pecs Medical School in Pecs, Hungary. He performed his residency in Internal Medicine at the Henry Ford Hospital in Detroit, MI, and completed a clinical fellowship in Nephrology at the Johns Hopkins Bayview Medical Center in Baltimore, MD.
Dr. Kovesdy’s principal research interests are centered on uncovering causes of morbidity and mortality in patients with all stages of chronic kidney disease, with active involvement in observational, interventional and translational research studies. Dr. Kovesdy has published his research in over 500 peer-reviewed articles, as well as numerous abstracts and book chapters. He is a member of the Executive Committee of the International Society of Renal Nutrition and Metabolism, a Fellow of the American Society of Nephrology, and a member of the International Society of Nephrology and the European Renal Association – European Dialysis and Transplant Association.
Association of Cannabis and Cannabinoid Use with Outcomes in Kidney Diseases and ESRD
October 25, 2020 | 11:00 AM - 11:30 AM
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- Cannabinoids and the Endocannabinoid System as a Target for Therapy in Diabetes, CKD, and ESRD
11:30 AM - 12:00 PM
Hamid Moradi, MD, FASN
Cannabinoids and the Endocannabinoid System as a Target for Therapy in Diabetes, CKD, and ESRD
October 25, 2020 | 11:30 AM - 12:00 PM
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