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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Novel Measures of Kidney Risk: Soluble Urokinase Receptor and the Plasminogen System

October 23, 2020 | 10:30 AM - 12:30 PM

Location: Simulive

Session Description

The soluble urokinase-type plasminogen activator receptor (suPAR) is a circulating immune-cell derived signaling molecule. Higher levels of plasma suPAR have been associated with increasing risk of CKD incidence and progression. Mice with higher suPAR levels develop renal injury. Novel assessment of kidney function beyond GFR and proteinuria are needed to improve patient risk stratification.
This session describes the signaling cascades engaged by molecules of the plasminogen system and how measuring suPAR may aid in reclassification of renal risk.

Learning Objective(s)

  • Discuss the biology of the soluble urokinase receptor and its effects on the kidney
  • Explain how measuring suPAR can help in assessing renal disease and clinical conditions with potential harm for the kidney
  • Describe how the kidney and the heart may be affected in concert by circulating inflammatory mediators
  • Assess the potential for therapeutic targeting of the plasminogen system to improve kidney health
  • Describe how the innate immune system and the kidney are partly co-regulated together

Learning Pathway(s)

  • Glomerular Diseases
  • Chronic Kidney Disease


  • Nada Alachkar, MD, FASN
  • Tobias B. Huber, MD, FASN


  • Soluble Urokinase Receptor: Biology and Implications for Glomerular Disease Pathogenesis
    10:30 AM - 11:00 AM
    Sanja Sever, PhD
  • Epidemiology of SuPAR as a Circulating Risk Factor for Kidney Disease
    11:00 AM - 11:30 AM
    Salim Hayek, MD 
  • CoFactors for Risk of FSGS Disease
    11:30 AM - 12:00 PM
    Minnie Sarwal, MD, PhD
  • suPAR and Complications of Diabetes Mellitus
    12:00 PM - 12:30 PM
    Peter Rossing, MD