Kidney Week

Basic/Clinical Science Session

Glomerular Disease Pathogenesis: What's New?

October 24, 2020 | 02:30 PM - 04:30 PM

Location: Simulive

Session Description

Taken together, primary and secondary glomerular diseases account for 90% of all ESKD in the United States, at a cost in excess of $20 billion per year. The development of novel therapeutics is limited by poor understanding of the underlying disease pathogenesis. This session highlights novel and emerging concepts driving the understanding of cellular injury, degeneration, and cross-talk that could help advance the quest for better treatment options.

Learning Objective(s)

• Identify glomerular metabolic changes in hypertensive nephropathy
• Define mechanisms underlying pathogenic endothelial-podocyte cross-talk
• Discuss the contribution of lipids to glomerular disease progression
• Describe the pathogenesis of immune-mediated podocyte injury

Learning Pathway(s)

• Glomerular Diseases
• Pathology

Moderators

• Kyung Lee, PhD
• Joshua M. Thurman, MD

Presentations

• Glomerular Metabolic Changes in Hypertensive Kidney Disease
  02:30 PM - 03:00 PM
  Markus M. Rinschen, MD
  

  Markus M. Rinschen, MD

Glomerular Metabolic Changes in Hypertensive Kidney Disease

October 24, 2020 | 02:30 PM - 03:00 PM

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• Mechanism of Pathogenic Podocyte-Endothelial Cross-Talk
  03:00 PM - 03:30 PM
  Ilse S. Daehn, PhD, FASN 
  
  

  Ilse S. Daehn, PhD, FASN

  My research focuses on exploring the complexity of signaling crosstalk between cells in the kidney. The major research interest is to understand the impact of redox processes and molecular mechanisms in the glomerulus that result in kidney disease progression in order to identify novel glomerular lesion-specific therapeutic targets and biomarkers. In particular we are examining the signaling crosstalk between podocytes, endocapillary cells and mesangial cells that lead to irreversible segmental sclerosis characteristic of glomerular disease progression.

Mechanism of Pathogenic Podocyte-Endothelial Cross-Talk

October 24, 2020 | 03:00 PM - 03:30 PM

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• Immune-Mediated Podocyte Injury: Pathogenesis and Therapeutic Opportunities
  03:30 PM - 04:00 PM
  Eunsil Hahm, PhD
  

  Eunsil Hahm, PhD

Immune-Mediated Podocyte Injury: Pathogenesis and Therapeutic Opportunities

October 24, 2020 | 03:30 PM - 04:00 PM

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• Lipids in Cellular Injury and Glomerular Disease
  04:00 PM - 04:30 PM
  Sandra M. Merscher, PhD 
  

  Sandra M. Merscher, PhD

  Dr. Merscher is a Research Associate Professor at the University of Miami – Miller School of Medicine, Miami, FL. Research in Dr. Merscher’s laboratory focuses on elucidating and understanding the molecular mechanisms that contribute to the development of proteinuria in glomerular diseases with an emphasis on lipotoxicity-induced podocyte injury. Dr. Merscher has co-authored more than 35 peer-reviewed journal articles, she is scientific reviewer for several peer-reviewed scientific journals, review editorial board member for Frontiers in Medicine (Nephrology), and has served as a grant reviewer for the American Heart Association since 2012. Research in Dr. Merscher’s laboratory is supported by several NIH- and industry-sponsored grants.

Lipids in Cellular Injury and Glomerular Disease

October 24, 2020 | 04:00 PM - 04:30 PM

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