Kidney Week

Basic/Clinical Science Session

Overflow by Gliflozins: Mechanisms and Consequences of the Off-Target Effects of SGLT2 Inhibitors

October 23, 2020 | 10:30 AM - 12:30 PM

Location: Simulive

Session Description

Sodium-glucose cotransporter 2 (SGLT2) inhibitors are new treatments approved by the US Food and Drug Administration for individuals with diabetic kidney disease. Although a primary mechanism of action is known, several additional renal and extrarenal perturbations have been discovered. The nature and contribution of these "off-target" effects are being elucidated. This session explores these effects and whether they play an instrumental or confounding role in the positive effects of SGLT2 inhibitors on renal and cardiovascular disease.

Learning Objective(s)

• Identify the mechanisms and consequences of sodium-hydrogen exchanger 3 (NHE3) inhibition by SGLT2 inhibitors
• Discuss the effects of SGLT2 inhibitors on divalent cation homeostasis, including calcium and magnesium
• Elucidate the potential role of uric acid excretion for observed benefits of SGLT2 inhibitors on kidney and cardiovascular disease
• Describe the direct effects of SGLT2 inhibitors on mitochondria and their downstream consequences

Learning Pathway(s)

• Cell and Transport Physiology
• Diabetes and Metabolism

Moderators

• Carolyn M. Ecelbarger, PhD
• Carol A. Pollock, MD, PhD

Presentations

• Role of Sodium-Hydrogen Exchanger 3 (NHE3) Inhibition and Sodium-Glucose Cotransporter 2 (SGLT2)-Mediated NHE3 Inhibition in the Diabetic Kidney
  10:30 AM - 11:00 AM
  Alicia A. McDonough, PhD
  

  Alicia A. McDonough, PhD

Role of Sodium-Hydrogen Exchanger 3 (NHE3) Inhibition and Sodium-Glucose Cotransporter 2 (SGLT2)-Mediated NHE3 Inhibition in the Diabetic Kidney

October 23, 2020 | 10:30 AM - 11:00 AM

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• Mechanisms of SGLT2 Inhibitor Nephroprotection Beyond Glomerular Hemodynamics
  11:00 AM - 11:30 AM
  Richard E. Gilbert, MD, PhD, FASN
  

  Richard E. Gilbert, MD, PhD, FASN

Mechanisms of SGLT2 Inhibitor Nephroprotection Beyond Glomerular Hemodynamics

October 23, 2020 | 11:00 AM - 11:30 AM

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• The Role of Uric Acid in Cardiorenal Benefits of SGLT2 Inhibition
  11:30 AM - 12:00 PM
  Clifford J. Bailey, PhD 
  
  

  Clifford J. Bailey, PhD

  Cliff Bailey is Emeritus Professor of Clinical Science at Aston University in Birmingham, England. He is a Fellow of the Royal College of Physicians of Edinburgh and a Fellow of the Royal College of Pathologists. He has been a Royal Society visiting scientist at the University of Southern California, Los Angeles, and a visiting scientist at Hanover Medical School in Germany. He has served on medical and scientific committees of Diabetes UK (formerly the British Diabetic Association), Society for Endocrinology, and European Association for the Study of Diabetes. Professor Bailey has held various editorial positions, including endocrine section editor of British Journal of Pharmacology and editorial board member of Diabetes, Obesity and Metabolism, LancetDE and Primary Care Diabetes. He is presently senior editor of Diabetes and Vascular Disease Research. He has been an expert witness for drug licensing authorities, regulatory agencies and other national and international review bodies. He received the 2013 Lunar Society medal and the 2015 Banting Lecture award. His research is mainly directed towards the pathogenesis and treatment of diabetes, especially the development of new agents to improve insulin action and reduce obesity, and the therapeutic application of surrogate beta-cells. He has published over 400 research papers and reviews, and five books.

The Role of Uric Acid in Cardiorenal Benefits of SGLT2 Inhibition

October 23, 2020 | 11:30 AM - 12:00 PM

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• Alterations in Mitochondrial Function by SGLT2 Inhibitors
  12:00 PM - 12:30 PM
  Tetsuji Miura, MD, PhD
  

  Tetsuji Miura, MD, PhD

Alterations in Mitochondrial Function by SGLT2 Inhibitors

October 23, 2020 | 12:00 PM - 12:30 PM

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