Unraveling Novel Molecular Targets in Diabetic Kidney Disease
October 24, 2020 | 10:00 AM - 12:00 PM
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Basic/Clinical Science Session
Unraveling Novel Molecular Targets in Diabetic Kidney Disease
October 24, 2020 | 10:00 AM - 12:00 PM
Location: On-Demand
Session Description
Several new potential therapeutic targets have emerged in recent studies in model systems of diabetic kidney disease (DKD), including immune regulators, mitochondrial activators, and improved endothelial function. This session addresses these novel mechanistic studies and potential for translation.
Learning Objective(s)
- Describe novel mechanistic targets for DKD treatment
- Discuss the potential roles of these targets in improving and preserving renal function
- Explain the therapeutic implications of these findings
Learning Pathway(s)
Moderators
- Farsad Afshinnia, MD, MS, FASN
- Frank C. Brosius, MD
Presentations
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The Role of Proximal Tubular Carnitine Acetltransferase in Mitochondrial Nutrient Handling and Energy Homeostasis
10:00 AM - 10:30 AM
Krisztian Stadler, PhD
The Role of Proximal Tubular Carnitine Acetltransferase in Mitochondrial Nutrient Handling and Energy Homeostasis
October 24, 2020 | 10:00 AM - 10:30 AM
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Soluble NogoB Improves DKD by Protecting Vasculature
10:30 AM - 11:00 AM
Luigi Gnudi, MD, PhD, FASN
Luigi Gnudi, MD, PhD, FASN
Soluble NogoB Improves DKD by Protecting Vasculature
October 24, 2020 | 10:30 AM - 11:00 AM
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Kruppel-Like Factors and DKD
11:00 AM - 11:30 AM
Sandeep K. Mallipattu, MD, FASN
Sandeep K. Mallipattu, MD, FASN
Kruppel-Like Factors and DKD
October 24, 2020 | 11:00 AM - 11:30 AM
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Blockade of the C5a-C5aR1 Axis in DKD
11:30 AM - 12:00 PM
Melinda T. Coughlan, PhD
Melinda T. Coughlan, PhD
Associate Professor Melinda Coughlan is Head of the Glycation, Nutrition & Metabolism Laboratory within the Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia. She studied Biology and Nutrition before obtaining a PhD from the University of Melbourne after which time she began research into complications of diabetes at the Baker Heart Research Institute. A major research interest is studying how the modern diet leads to the initiation or worsening of inflammation and chronic disease, with a focus on diabetes and its complications. A/Prof Coughlan has already made a number of exciting and important observations in the preclinical space with respect to drug target identification and has now extended her research to translational studies. She currently holds funding from NHMRC and a Career Development Fellowship from the JDRF’s Australian Type 1 Diabetes Clinical Research Network for her work into diabetes and its complications.
Blockade of the C5a-C5aR1 Axis in DKD
October 24, 2020 | 11:30 AM - 12:00 PM
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