Unraveling Novel Molecular Targets in Diabetic Kidney Disease
October 24, 2020 | 10:00 AM - 12:00 PM
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Basic/Clinical Science Session
Unraveling Novel Molecular Targets in Diabetic Kidney Disease
October 24, 2020 | 10:00 AM - 12:00 PM
Location: On-Demand
Session Description
Several new potential therapeutic targets have emerged in recent studies in model systems of diabetic kidney disease (DKD), including immune regulators, mitochondrial activators, and improved endothelial function. This session addresses these novel mechanistic studies and potential for translation.
Learning Objective(s)
- Describe novel mechanistic targets for DKD treatment
- Discuss the potential roles of these targets in improving and preserving renal function
- Explain the therapeutic implications of these findings
Learning Pathway(s)
Moderators
- Farsad Afshinnia, MD, MS, FASN
- Frank C. Brosius, MD
Presentations
- The Role of Proximal Tubular Carnitine Acetltransferase in Mitochondrial Nutrient Handling and Energy Homeostasis
10:00 AM - 10:30 AM
Krisztian Stadler, PhD
Krisztian Stadler, PhD
I have more than 20 years of experience in metabolic diseases and direct in vivo detection of free radicals, applying state-of-the-art biophysical approaches like electron paramagnetic resonance (EPR) spectroscopy. I was trained at a top tier institute (NIEHS/NIH) in oxidative stress and diseases, focusing on obesity and diabetes and their complications. Proper assessment and direct detection of free radical mechanisms in vivo requires combined and in-depth knowledge of biophysics, biochemistry and physiology/pathology.
After my training, I launched my own research group at the Pennington Biomedical Research Center where currently I am a tenured Principal Investigator. Projects in our laboratory focus on redox mechanisms in metabolic diseases such as diabetes, obesity and insulin resistance. Our specific interests are mitochondrial substrate and energy balance and diabetic complications such as diabetic nephropathy. These projects have high translational value as unraveling the role of specific redox signaling in diabetic kidney disease or insulin resistance may lead to new preventative approaches in these areas.
The Role of Proximal Tubular Carnitine Acetltransferase in Mitochondrial Nutrient Handling and Energy Homeostasis
October 24, 2020 | 10:00 AM - 10:30 AM
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- Soluble NogoB Improves DKD by Protecting Vasculature
10:30 AM - 11:00 AM
Luigi Gnudi, MD, PhD, FASN
Luigi Gnudi, MD, PhD, FASN
Luigi Gnudi obtained his MD with Honors from the University of Parma (Italy) in 1988 and specialty in Diabetes and Endocrinology at the University of Padua (Italy) (1989-1993). During 1992-1995 he worked as a postdoctoral fellow at Harvard Medical School in Boston. In 1999 he obtained a PhD in Endocrinological Sciences from the University of Milan.
He is currently Professor of Diabetes & Metabolic Medicine at King’ College London and Consultant in Diabetes and Endocrinology. He runs the diabetes-renal service at GSTT.
Luigi Gnudi is academically internationally well recognized. He speaks frequently at national and international meetings and is an active researcher, clinician, and teacher with major research interests in the study of diabetic nephropathy and diabetic vascular complications in preclinical models and in man.
He has published more than 100 original papers, books and monographs and meeting proceedings on these topics.
He was nominated UK’s 25 most influential researchers who study diabetes complications (2019), awarded the Ruth Osterby Price by the European Diabetic Nephropathy Study Group (Helsinki, 2017), the Viswanathan Honor Award Oration (Chennai, 2016) and the Candlelight lecture (Heidelberg, 2015).
Soluble NogoB Improves DKD by Protecting Vasculature
October 24, 2020 | 10:30 AM - 11:00 AM
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- Kruppel-Like Factors and DKD
11:00 AM - 11:30 AM
Sandeep K. Mallipattu, MD, FASN
Sandeep K. Mallipattu, MD, FASN
The focus of our research is on the molecular mechanisms mediating the development and progression of chronic kidney disease. Our laboratory concentrates on the essential role of a family of zinc finger transcription factors called Krüppel-Like Factors (KLFs). We have found evidence that specific KLFs are critically involved in regulating fundamental cellular processes in the kidney such as epithelial cell differentiation, cell-cycle, and metabolic processes (mitochondrial complex assembly, fatty acid oxidation, amino acid metabolism) using novel high throughput assays.
Kruppel-Like Factors and DKD
October 24, 2020 | 11:00 AM - 11:30 AM
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- Blockade of the C5a-C5aR1 Axis in DKD
11:30 AM - 12:00 PM
Melinda T. Coughlan, PhD
Melinda T. Coughlan, PhD
Associate Professor Melinda Coughlan is Head of the Glycation, Nutrition & Metabolism Laboratory within the Department of Diabetes, Central Clinical School, Monash University, Melbourne, Australia. She studied Biology and Nutrition before obtaining a PhD from the University of Melbourne after which time she began research into complications of diabetes at the Baker Heart Research Institute. A major research interest is studying how the modern diet leads to the initiation or worsening of inflammation and chronic disease, with a focus on diabetes and its complications. A/Prof Coughlan has already made a number of exciting and important observations in the preclinical space with respect to drug target identification and has now extended her research to translational studies. She currently holds funding from NHMRC and a Career Development Fellowship from the JDRF’s Australian Type 1 Diabetes Clinical Research Network for her work into diabetes and its complications.
Blockade of the C5a-C5aR1 Axis in DKD
October 24, 2020 | 11:30 AM - 12:00 PM
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