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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Out on a Limb: Loop of Henle and JGA Functions

October 23, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

The loop of Henle and juxtaglomerular apparatus (JGA) are critical for both monovalent (Na, K, Cl) and divalent (Ca, Mg) ion and water transport and for intranephron cross-talk. The thick limb was not classically accessible by micropuncture, so our knowledge of molecular mechanisms within this segment has lagged that of more proximal and distal nephron segments. This session discusses insights into the molecular mechanisms of this segment that have been elucidated by recent genetic and imaging techniques and their implications for hypertension, dysnatremias, and edema-forming states.

Learning Objective(s)

  • Identify novel regulators of Na-K-2Cl transporters in the thick ascending limb and macula densa
  • Identify novel vasopressin-dependent mechanisms that generate and maintain the hyperosmotic medulla
  • Discuss insights into signaling mechanisms that govern tubuloglomerular feedback
  • Discuss insights into signaling mechanisms that govern renin-secreting cells

Learning Pathway(s)

  • Cell and Transport Physiology
  • Hypertension and CVD


  • Mariela Mendez, PhD
  • Janos Peti-Peterdi, MD, PhD


  • The Role of ALMS1 in NKCC2-Mediated Sodium Reabsorption
    10:00 AM - 10:30 AM
    Ankita Bachhawat Jaykumar, PhD
  • Mechanisms of Vasopressin-Mediated Stimulation of NKCC2
    10:30 AM - 11:00 AM
    Kerim Mutig, DrMed
  • The Role of NOS1 Within the Macula Densa to Control Tubuloglomerular Feedback
    11:00 AM - 11:30 AM
    Lei Wang, PhD
  • Renin Cell Identity and Homeostasis
    11:30 AM - 12:00 PM
    Maria Luisa S. Sequeira Lopez, MD