Kidney Week

Clinical Practice Session

Emerging Trends in Drug-Induced Toxic Nephropathies

October 25, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

Toxic nephropathies are common and important causes of AKI. New causes and mechanisms of nephrotoxicity are continuously discovered. This session examines the nephrotoxicity of newer therapeutic agents and recreational drugs and discusses newer concepts regarding the toxicity of more classic nephrotoxic drugs. Descriptions of clinical characteristics and therapeutic approaches are also reviewed.

Learning Objective(s)

• Describe the renal toxic effects of classic and more novel recreational drugs
• Report ongoing advances in identifying the nephrotoxicity of newer cancer treatments and their mechanisms, diagnosis, and therapeutics
• Discuss the changing patterns of antibiotic-associated AKI
• Define the acid-base and electrolyte consequences of antibiotic-induced renal tubular injury

Learning Pathway(s)

• Acute Kidney Injury
• Cell and Transport Physiology

Moderators

• John M. Arthur, MD, PhD, FASN
• Umut Selamet, MD, FASN

Presentations

• Newer Recreational Drugs and AKI
  10:00 AM - 10:30 AM
  Randy L. Luciano, MD, PhD
  

  Randy L. Luciano, MD, PhD

Newer Recreational Drugs and AKI

October 25, 2020 | 10:00 AM - 10:30 AM

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• Nephrotoxicity Spectrum in the Era of Cancer Chemotherapy and Immunotherapy: How to Overcome
  10:30 AM - 11:00 AM
  Sandra Herrmann, MD 
  
  

  Sandra Herrmann, MD

  Dr Sandra Herrmann is Associate Professor at the Mayo College of Medicine and a consultant in the Division of Nephrology and Hypertension at Mayo Clinic, Rochester, MN, USA. She obtained her medical degree from the Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Porto Alegre, Brazil and completed her Internship and Nephrology fellowship at the PUCRS -Hospital Sao Lucas. She did her post-doctoral research fellowship and then completed her Internal Medicine Residency and Nephrology Fellowship at the Mayo Clinic, Rochester, MN, USA. She is a member of various scientific societies including American Society of Nephrology and The National Kidney Foundation. Her research interests are renovascular hypertension, regenerative medicine and onco-nephrology. She currently holds a NIH-K08 career development award looking at hypoxic preconditioning to improve adipose-derived mesenchymal stem cells function from patients hypertensive kidney disease. Dr. Herrmann's research in onco-nephrology is focused on kidney diseases caused by hematologic diseases and on nephrotoxicity of cancer therapeutic agents such as immune checkpoint inhibitors, chimeric antigen receptor (CAR)-T cell therapy and other targeted cancer therapies.

Nephrotoxicity Spectrum in the Era of Cancer Chemotherapy and Immunotherapy: How to Overcome

October 25, 2020 | 10:30 AM - 11:00 AM

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• Changing Patterns and Mechanisms of Antibiotic-Associated Nephrotoxicity
  11:00 AM - 11:30 AM
  Juan Carlos Q. Velez, MD, FASN 
  
  

  Juan Carlos Q. Velez, MD, FASN

  Dr. Juan Carlos Q. Velez earned a medical degree from Universidad Peruana Cayetano Heredia in Lima, Peru. He completed internship and residency in Internal Medicine at Advocate Illinois Masonic Medical Center in Chicago, where he served as Chief Medical Resident. Subsequently, he completed a clinical and research fellowship in Nephrology at Emory University School of Medicine. Following his training, he joined the Division of Nephrology at the Medical University of South Carolina (MUSC). After spending 11 years of intense clinical, educational and investigational efforts at MUSC, he was recruited by the Department of Nephrology at the Ochsner Clinic Foundation in 2016 to enhance the academic and clinical research programs of the department at the rank of Associate Professor of Medicine at Ochsner Clinical School / The University of Queensland (Brisbane, Australia). He serves as Clerkship Director for Medical Specialties at Ochsner Clinical School. He was appointed as Chair of Nephrology at Ochsner Health System in early 2019. Dr. Velez also holds an appointment as Adjunct Associate Professor of Physiology at Tulane University. Dr. Velez has conducted experimental research in the area of the intrarenal renin-angiotensin system (RAS) that resulted in federal funding and peer-reviewed publications. His work highlighted the role of the angiotensinase aminopeptidase A in glomerular RAS homeostasis. Currently, his areas of expertise and ongoing basic, clinical and translational investigation include hepatorenal syndrome, urinary sediment microscopy, hyponatremia, proteinuric glomerular diseases, kidney ultrasonography, renal syndromes associated with exposure to antimicrobials, and more recently, kidney disease associated with COVID-19. Dr. Velez is certified in Nephrology by the American Board of Internal Medicine, in Kidney Ultrasonography by the American Society of Diagnostic and Interventional Nephrology, and as a Hypertension Specialist by the American Society of Hypertension. He is a selected member of the SSCI. In addition, he served in the American Society of Nephrology (ASN) / National Board of Medical Examiners Fellows In-Training Examination Development Committee. He is a current member of the editorial board of Kidney360 and the ASN COVID-19 Acute Kidney Care Subcommittee.

Changing Patterns and Mechanisms of Antibiotic-Associated Nephrotoxicity

October 25, 2020 | 11:00 AM - 11:30 AM

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• Acid-Base and Electrolyte Disorders Associated with Antibiotic Therapy
  11:30 AM - 12:00 PM
  Robert Zietse, MD, PhD 
  
  

  Robert Zietse, MD, PhD

Acid-Base and Electrolyte Disorders Associated with Antibiotic Therapy

October 25, 2020 | 11:30 AM - 12:00 PM

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