Branching Out: How Does the Collecting Duct Form?
October 22, 2020 | 10:00 AM - 12:00 PM
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Basic/Clinical Science Session
Branching Out: How Does the Collecting Duct Form?
October 22, 2020 | 10:00 AM - 12:00 PM
Location: On-Demand
Session Description
This session covers new developments in our understanding of the developmental processes controlling collecting duct formation in the kidney.
Learning Objective(s)
- Outline the basic process of collecting duct formation
- Describe the molecular mechanisms underlying control of collecting duct formation and how they are perturbed in congenital human disease
Learning Pathway(s)
- Development and Pediatrics
- Genetic Diseases of the Kidneys
Moderators
- Nuria M. Pastor-Soler, MD, PhD, FASN
- Kameswaran Surendran, PhD
Presentations
- Mechanisms of Continual Growth of the Collecting System in Zebrafish
10:00 AM - 10:30 AM
Iain A. Drummond, PhD
Mechanisms of Continual Growth of the Collecting System in Zebrafish
October 22, 2020 | 10:00 AM - 10:30 AM
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- Genetic Mechanisms Controlling Mouse Collecting Duct Growth and Branching
10:30 AM - 11:00 AM
Helen McNeill, PhD
Genetic Mechanisms Controlling Mouse Collecting Duct Growth and Branching
October 22, 2020 | 10:30 AM - 11:00 AM
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- Collecting Duct Growth and Branching in Human Organoids
11:00 AM - 11:30 AM
Ryuichi Nishinakamura, MD, PhD
Ryuichi Nishinakamura, MD, PhD
Ryuichi Nishinakamura graduated from Department of Medicine, the University of Tokyo, and spent several years as a clinical nephrologist. After obtaining his Ph.D., he started working on kidney development at the University of Tokyo. He is now a Professor in the Department of Kidney Development, at the Institute of Molecular Embryology and Genetics, Kumamoto University, Japan. His ultimate goal is to elucidate molecular mechanisms underlying kidney development and to utilize the obtained knowledge to rebuild the kidney from pluripotent stem cells.
Collecting Duct Growth and Branching in Human Organoids
October 22, 2020 | 11:00 AM - 11:30 AM
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- Genetics of Human Collecting System Development
11:30 AM - 12:00 PM
Adrian S. Woolf, MD
Adrian S. Woolf, MD
Adrian S. Woolf is Professor of Paediatric Science in the Division of Cell Matrix Biology & Regenerative Medicine, in the Faculty of Biology, Medicine & Health in the University of Manchester.
He is also an Honorary Consultant Nephrologist at Royal Manchester Children’s Hospital, and an Honorary Professor at University College London.
Qualifications: 1981 MB BS, University of London (Honours in Medicine); 1982 MA, University of Cambridge; 1984 MRCP II UK: 1989 MD Thesis, University of London.
As a Travelling Research Fellow at UCLA (1989-1991), he became interested in how kidneys form and grow. He returned to the UK as a Kidney Research UK Senior Fellow (1991-1996) to establish his research group in the Developmental Biology Unit, Institute of Child Health, London (now UCL). There, in 1998, he created the academic Nephro-Urology Unit and was promoted to UCL Professor of Nephrology in 2000.
In 2010 he was appointed as Chair of Paediatric Science in the University of Manchester and he is also a member of the University Senate.
He has three decades experience as a clinician scientist and uses human genomics, and preclinical and stem cell models to: i. pinpoint genetic and environmental causes of renal tract congenital malformations; ii. define the roles of implicated molecules in organogenesis and differentiation; and iii. design therapies to prevent malformations and promote regeneration.
He co-authored the UK Renal Research Strategy (2016), the first research blueprint for the speciality. He has supervised science and clinical students leading to 16 PhD awarded theses.
In 2010 he established a multidisciplinary Renal Genetics clinic in the Royal Manchester Children’s Hospital. Making a specific genetic diagnosis can provide a family with an answer to their often long-sought question “why was our child born with devastating disease”.
Genetics of Human Collecting System Development
October 22, 2020 | 11:30 AM - 12:00 PM
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