Kidney Week

Basic/Clinical Science Session

C3 Glomerulopathy and aHUS: From Diagnosis to Transplantation

October 24, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

C3 glomerulopathies and atypical hemolytic uremic syndrome (aHUS) comprise different disease entities that are (almost always) caused by dysregulated complement. This session reviews the spectrum of these diseases from initial diagnosis to post-transplant management. We discuss the etiologic and histologic characteristics of C3 glomerulopathies and aHUS, as well as approaches to diagnosing underlying complement abnormalities and applying that information in patient management.

Learning Objective(s)

• Explain the different etiologies and histopathologic manifestations of C3 glomerulopathies and aHUS
• Identify the components of the complement pathway and how they can be evaluated in C3 glomerulopathy and aHUS
• Describe the process of consolidating diagnostic and prognostic information to manage patients awaiting kidney transplantation
• Interpret the rationale and the options of immunosuppressive and complement-targeted therapies, including those for kidney transplant recipients

Learning Pathway(s)

• Glomerular Diseases
• Transplantation/Immunology

Moderators

• Kerstin U. Amann, MD
• Vineeta Kumar, MD

Presentations

• The Histopathologic Spectrum of C3 Glomerulopathies and aHUS
  10:00 AM - 10:30 AM
  Vivette D. D'Agati, MD
  

  Vivette D. D'Agati, MD

The Histopathologic Spectrum of C3 Glomerulopathies and aHUS

October 24, 2020 | 10:00 AM - 10:30 AM

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• Complement Abnormalities and Rational Diagnostic in C3 Glomerulopathy and aHUS
  10:30 AM - 11:00 AM
  Neil S. Sheerin, MBBS, PhD
  

  Neil S. Sheerin, MBBS, PhD

Complement Abnormalities and Rational Diagnostic in C3 Glomerulopathy and aHUS

October 24, 2020 | 10:30 AM - 11:00 AM

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• How to Inhibit Complement in Patients With C3 Glomerulopathy aHUS
  11:00 AM - 11:30 AM
  Peter F. Zipfel, PhD
  

  Peter F. Zipfel, PhD

How to Inhibit Complement in Patients With C3 Glomerulopathy aHUS

October 24, 2020 | 11:00 AM - 11:30 AM

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• Treating Patients with C3 Glomerulopathy and aHUS, Including the Kidney Transplant Candidate
  11:30 AM - 12:00 PM
  Carla Marie Nester, MD, MS, FASN 
  

  Carla Marie Nester, MD, MS, FASN

  Dr. Nester is the Jean E. Robillard, MD Chair and Director of the Division of Pediatric Nephrology, Dialysis and Transplantation - Stead Family Children's Hospital, Iowa, USA. In addition, she is the Associate Director of the Clinical and Research Laboratory, Molecular Otolaryngology and Renal Research Laboratory. Dr. Nester is an Associate Professor in the Department of Internal Medicine and the Department of Pediatrics at the University of Iowa.

Treating Patients with C3 Glomerulopathy and aHUS, Including the Kidney Transplant Candidate

October 24, 2020 | 11:30 AM - 12:00 PM

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