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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

C3 Glomerulopathy and aHUS: From Diagnosis to Transplantation

October 24, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

C3 glomerulopathies and atypical hemolytic uremic syndrome (aHUS) comprise different disease entities that are (almost always) caused by dysregulated complement. This session reviews the spectrum of these diseases from initial diagnosis to post-transplant management. We discuss the etiologic and histologic characteristics of C3 glomerulopathies and aHUS, as well as approaches to diagnosing underlying complement abnormalities and applying that information in patient management.

Learning Objective(s)

  • Explain the different etiologies and histopathologic manifestations of C3 glomerulopathies and aHUS
  • Identify the components of the complement pathway and how they can be evaluated in C3 glomerulopathy and aHUS
  • Describe the process of consolidating diagnostic and prognostic information to manage patients awaiting kidney transplantation
  • Interpret the rationale and the options of immunosuppressive and complement-targeted therapies, including those for kidney transplant recipients

Learning Pathway(s)

  • Glomerular Diseases
  • Transplantation/Immunology


  • Kerstin U. Amann, MD
  • Vineeta Kumar, MD


  • The Histopathologic Spectrum of C3 Glomerulopathies and aHUS
    10:00 AM - 10:30 AM
    Vivette D. D'Agati, MD
  • Complement Abnormalities and Rational Diagnostic in C3 Glomerulopathy and aHUS
    10:30 AM - 11:00 AM
    Neil S. Sheerin, MBBS, PhD
  • How to Inhibit Complement in Patients With C3 Glomerulopathy aHUS
    11:00 AM - 11:30 AM
    Peter F. Zipfel, PhD
  • Treating Patients with C3 Glomerulopathy and aHUS, Including the Kidney Transplant Candidate
    11:30 AM - 12:00 PM
    Carla Marie Nester, MD, MS, FASN