Kidney Week

Basic/Clinical Science Session

Organelle Function and Dysfunction in Kidney Diseases

October 24, 2020 | 10:00 AM - 12:00 PM

Location: On-Demand

Session Description

Recent technological advances have revealed critical roles for varied intracellular organelles in the pathogenesis of kidney diseases. In addition, organelles can cross-talk, adding a layer of complexity to organelle regulation. Understanding dynamic organelle signaling can help us better understand pathologies of renal disease and can also lead to novel therapies.

Learning Objective(s)

• Describe the in-depth organelle biology in the kidney
• Explain how organelle cross-talk can influence cell function
• Discuss novel therapeutics that target the endoplasmic reticulum

Learning Pathway(s)

• Cell and Transport Physiology

Moderators

• Uta Erdbruegger, MD
• Jennie Lin, MD, MS

Presentations

• Developing Novel Endoplasmic Reticulum-Targeted Treatment for Kidney Diseases
  10:00 AM - 10:30 AM
  Ying Maggie Chen, MD, PhD, FASN 
  
  

  Ying Maggie Chen, MD, PhD, FASN

Developing Novel Endoplasmic Reticulum-Targeted Treatment for Kidney Diseases

October 24, 2020 | 10:00 AM - 10:30 AM

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• Endoplasmic Reticulum-Associated Degradation Component SEL1L in Nephrotic Syndrome
  10:30 AM - 11:00 AM
  Ling Qi, PhD 
  
  

  Ling Qi, PhD

  Dr. Qi is Professor at the Department of Molecular & Integrative Physiology and the Department of Internal Medicine at the University of Michigan Medical School. He obtained his BS from Fudan University in 1997, majoring in microbiology, and PhD from University of Maryland in 2001, majoring in Immunology. He then went on to complete two postdoctoral fellowships at the Greider and Montminy laboratories. In 2007, he started his independent career at Cornell University and promoted to Associate Professor in 2013. In 2016, he was recruited to University of Michigan Medical School as full Professor. The Qi laboratory is leading the effort to delineate the role of endoplasmic reticulum-associated protein degradation (ERAD) in health and disease. Work from his laboratory has demonstrated the physiological importance of ERAD in cell type specific manner, and revealed pathological significance of ERAD as a potential target in many human diseases. In addition to research, he is a dedicated teacher and mentor. In May of 2014, he was awarded the SUNY Chancellor’s Award for Excellence in Teaching, a top award for the best teacher in New York State. He was the Chair of NIH Cellular Aspects of Diabetes and Obesity (CADO) study section and the former President of Chinese American Diabetes Association (CADA).

Endoplasmic Reticulum-Associated Degradation Component SEL1L in Nephrotic Syndrome

October 24, 2020 | 10:30 AM - 11:00 AM

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• Organelle Cross-Talk and Tubular Inflammation
  11:00 AM - 11:30 AM
  Reiko Inagi, PhD 
  
  

  Reiko Inagi, PhD

  Prof. Reiko Inagi is a Division chief of CKD Pathophysiology, The University of Tokyo School of Graduate Medicine. She earned her Ph.D. in Immunology from Nagoya University Graduate School of Medicine, Japan, in 1990. She has researched the Virology at Osaka University School of Medicine as an assistant professor (1991-1998), moved to Tokai University School of Medicine as a lecturer, and began her studies on molecular nephrology. She got the “Kimoto Award” of the Japanese Society for Dialysis Therapy in 2003. Since 2008, she has been assigned to the present position and her recent professional interests are pathophysiological role of oxidative, hypoxic, or organelle (ER and mitochondrial) stress in kidney diseases and kidney aging. She is a councilor/secretary of Japanese Society of Nephrology and International Maillard Reaction Society, an Associate Editor of “Clinical and Experimental Pharmacology and Physiology” and “Kidney 360”, and Editorial board of “American Journal of Physiology-Renal Physiology” and “Kidney International”.

Organelle Cross-Talk and Tubular Inflammation

October 24, 2020 | 11:00 AM - 11:30 AM

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• Polycystic and Tubulointerstitial Phenotypes of ER Genes in the Kidney
  11:30 AM - 12:00 PM
  Whitney Besse, MD
  

  Whitney Besse, MD

Polycystic and Tubulointerstitial Phenotypes of ER Genes in the Kidney

October 24, 2020 | 11:30 AM - 12:00 PM

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