Kidney Week

Educational Symposium

Hepatorenal Syndrome Type 1: Diagnosis Methods and Management

October 23, 2020 | 01:00 PM - 02:00 PM

Location: Simulive

Session Description

Hepatorenal syndrome (HRS) type 1 is an AKI characterized by rapid and progressive loss of kidney function in patients with liver disease. AKI is common in patients with advanced liver disease, and HRS is a diagnosis of exclusion.

Because AKI among patients with liver disease can have a variety of causes, the diagnosis of HRS is often difficult to make, which has important ramifications from a prognostic and therapeutic standpoint. Indeed, a diagnosis of HRS type 1 implies a very high morbidity and mortality, which can lead to premature decision-making about therapy. Clinical research is currently exploring more accurate methods for establishing a diagnosis of HRS. This symposium provides an update on the tests used to diagnose and classify AKI in cirrhosis and HRS.

Treating AKI in liver disease includes the treatment of volume depletion (typically with albumin), abdominal compartment syndrome (if present), and associated infections, as well as the use of vasopressors and RRT. With the exception of reversible acute liver injury, the definitive treatment of HRS is liver transplantation.

Support is provided by an educational grant from Mallinckrodt LLC.

Learning Objective(s)

• Describe the diagnostic methodology for HRS and differentiate it from AKI in liver cirrhosis
• Discuss the therapeutic approach to HRS type 1

Learning Pathway(s)

• Acute Kidney Injury

Moderator

• Chirag R. Parikh, MD, PhD, FASN

Presentations

• Introduction
  01:00 PM - 01:10 PM
  Chirag R. Parikh, MD, PhD, FASN
  
  Chirag R. Parikh, MD, PhD, FASN

Introduction

October 23, 2020 | 01:00 PM - 01:10 PM

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• Diagnostic Methods and Classification of AKI in Cirrhosis: Establishing HRS Type 1
  01:10 PM - 01:35 PM
  Justin Miles Belcher, MD, PhD 
  
  Justin Miles Belcher, MD, PhD

  Dr. Belcher grew up in Connecticut before attending Williams College where he graduated cum laude with a degree in history. He then attended medical school at Drexel University College of Medicine where he was elected to Alpha Omega Alpha, before completing his internship, residency, and Chief Residency in Internal Medicine at George Washington University. While completing his research fellowship in nephrology at Yale, he received a PhD in 2014 from the Investigative Medicine Program. The primary focus of his research is on acute kidney injury in patients with cirrhosis including the use of novel biomarkers to enhance diagnosis, therapeutic decisions and prognosis.

Diagnostic Methods and Classification of AKI in Cirrhosis: Establishing HRS Type 1

October 23, 2020 | 01:10 PM - 01:35 PM

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• Therapeutic Approach for Patients with HRS Type 1
  01:35 PM - 02:00 PM
  Andrew S. Allegretti, MD, MS
  
  Andrew S. Allegretti, MD, MS

Therapeutic Approach for Patients with HRS Type 1

October 23, 2020 | 01:35 PM - 02:00 PM

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