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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Educational Symposium

Causes and Treatments for CKD-Associated Pruritus

October 24, 2020 | 01:00 PM - 02:00 PM

Location: Simulive

Session Description

CKD-associated pruritus (CKD-aP) is common and affects the morbidity and quality of life of patients with CKD. The pathogenesis of CKD-aP is not completely understood but is likely multifactorial. Several hypotheses have been proposed, including metabolic disturbances, dysregulated immune response, and imbalances in the endogenous opioid system.

Despite the impact of CKD-aP, no professional nephrology societies have issued diagnostic or treatment guidelines, and no therapies have been approved in the United States or Europe. Treatment is currently limited to off-label therapies with limited effectiveness or substantial adverse effects, but emerging treatments are being investigated.

This symposium reviews the current evidence and pathophysiology of CKD-aP and provides information for nephrology clinicians to guide their treatment plans.

Support is provided by an educational grant from Cara Therapeutics, Inc.

Learning Objective(s)

  • Define the prevalence and burden of CKD-aP
  • Describe the pathophysiology and proposed etiologies for CKD-aP
  • Discuss available recommendations for evaluation and treatment along with emerging therapies

Learning Pathway(s)

  • Chronic Kidney Disease
  • Pathology


  • Divya Monga, MD


  • Introduction
    01:00 PM - 01:10 PM
    Divya Monga, MD
  • Pathophysiology and Etiology of CKD-Associated Pruritus
    01:10 PM - 01:35 PM
    Sara Combs, MD, MS 
  • Evaluating and Treating Patients Who Itch
    01:35 PM - 02:00 PM
    Peter Juergensen, PA-C