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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Kidney as a Metabolic Organ: Glucotoxicity and Lipotoxicity, Including the Robert W. Schrier, MD, Endowed Lectureship

November 05, 2021 | 10:00 AM - 12:00 PM

Location: On-Demand, Virtual Only

Session Description

This session discusses abnormal metabolism contributing to the pathogenesis of various kidney diseases. Glucotoxicity contributes to diabetic kidney disease (DKD). Lipotoxicity contributes not only to lipoprotein nephropathy but also to CKD. Such metabolic toxicity damages renal energy metabolism. Further, ketone bodies exert kidney protection as a new energy source in patients treated with a sodium-glucose cotransporter 2 (SGLT2) inhibitor, while a hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitor can change energy metabolism to improve disease phenotypes. Abnormal metabolisms affect various organs and organelles, accelerating disease progression and comorbidities via organ cross-talk in CKD and DKD.

ASN gratefully acknowledges Otsuka America Pharmaceutical, Novartis, Astellas Pharma US, and several individuals for support of the Robert W. Schrier, MD, Endowed Lectureship.

Learning Objective(s)

  • Describe the pathophysiology of abnormal metabolism, especially glucose-lipid metabolism imbalance in the kidneys
  • Outline the metabolic consequences of medication used in patients with CKD
  • Discuss the pathomechanisms of metabolism-related organ cross-talk
  • Discuss the pathomechanisms of metabolism-related organelle stress

Learning Pathway(s)

  • Chronic Kidney Disease


  • Jeffrey R. Schelling, MD
  • Tomoko Takano, MD, PhD


  • Glucotoxicity and Energy Metabolic Abnormality in CKD
    10:00 AM - 12:00 PM
    Prabhleen Singh, MD, MPH
  • Lipotoxicity in CKD
    10:00 AM - 12:00 PM
    Alessia Fornoni, MD, PhD, FASN
  • Glucotoxicity and Lipotoxicity Mediated by Endoplasmic Reticulum Stress
    10:00 AM - 12:00 PM
    Sydney C.W. Tang, MBBS, MD, PhD
  • Oxygen Biology and Metabolism in the Kidneys: The Robert W. Schrier, MD, Endowed Lectureship
    10:00 AM - 12:00 PM
    Masaomi Nangaku, MD, PhD