ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Tough Neighborhood: Tissue Microenvironment and Kidney Fibrosis

November 04, 2021 | 02:00 PM - 03:30 PM

Location: Live-Stream, Virtual Only

Session Description

Kidney fibrosis is initiated at certain focal sites in which the fibrogenic niche provides a specialized microenvironment that facilitates myofibroblast activation. It is believed that extracellular matricellular proteins such as connective tissue growth factor (CTGF), periostin, and others play an important role in orchestrating the formation of a fibrogenic niche. This session discusses emerging literature on the cellular origins of myofibroblasts and the role of matricellular proteins in their activation after injury.

Learning Objective(s)

  • Describe the origin, functional heterogeneity, and regulation of matrix-producing cells in kidney fibrosis
  • Discuss the role of 1connective tissue growth factor in the pathogenesis of kidney fibrosis
  • Explain how matricellular protein periostin mediates myofibroblast activation

Learning Pathway(s)

  • Pathology
  • Chronic Kidney Disease


  • Leslie S. Gewin, MD
  • Yufeng Huang, MD, PhD


  • Mapping Matrix-Producing Cells in Human Fibrotic Kidney
    02:00 PM - 02:30 PM
    Rafael Kramann, MD, PhD, FASN
  • Periostin in Kidney Fibrosis and CKD Progression
    02:30 PM - 03:00 PM
    Christos Chatziantoniou, PhD
  • Connective Tissue Growth Factor: From Basics to Clinics
    03:00 PM - 03:30 PM
    Roel Goldschmeding, MD, PhD