ASN's Mission

ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

APOL1 Epidemiology, Causal Mechanisms, and Therapeutics: Are We There Yet?

November 06, 2021 | 10:30 AM - 12:30 PM

Location: Live-Stream, Virtual Only

Session Description

It is 11 years after the first publication about APOL1 as a major driver of kidney diseases in Black people in the United States. We now know much more about the extent to which APOL1 genetic variants affect kidney health. This session assesses what we definitively know about the epidemiology, biologic mechanisms, and treatment strategies for APOL1-associated kidney disease and where gaps remain for more comprehensive understanding.

Learning Objective(s)

  • Explain how APOL1 affects pregnancy and perinatal outcomes and childhood kidney health
  • Describe the contribution of APOL1 genetic variation to other kidney and cardiovascular phenotypes as assessed from population-based cohorts
  • Identify the major biologic mechanisms causing or contributing to APOL1 kidney disease, and discuss how we might target them for precision therapeutics

Learning Pathway(s)

  • Genetic Diseases of the Kidneys


  • Jennie Lin, MD, MS
  • Matt G. Sampson, MD


  • APOL1 from a Prenatal, Perinatal, and Pediatric Perspective
    10:30 AM - 11:00 AM
    Kimberly J. Reidy, MD
  • APOL1 Insights from Population-Based Cohorts: Complex Kidney Traits and Beyond
    11:00 AM - 11:30 AM
    Rulan S. Parekh, MD, MS, FASN
  • APOL1 Mechanistic and Evolutionary Aspects
    11:30 AM - 12:00 PM
    David J. Friedman, MD
  • Therapeutic Prospects for APOL1-Associated Kidney Disease
    12:00 PM - 12:30 PM
    Karl Skorecki, MD, FASN