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ASN leads the fight to prevent, treat, and cure kidney diseases throughout the world by educating health professionals and scientists, advancing research and innovation, communicating new knowledge, and advocating for the highest quality care for patients.

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Kidney Week

Basic/Clinical Science Session

Thinking Beyond Tolvaptan: Regulation of Aquaporin 2 and Water Handling

November 04, 2021 | 10:30 AM - 12:30 PM

Location: Live-Stream, Virtual Only

Session Description

The body precisely regulates plasma tonicity. Osmotic and non-osmotic release of vasopressin can activate vasopressin 2 receptors to increase water reabsorption and cause hyponatremia; conversely, inhibition of this pathway can lead to hypernatremia. Human genetic diseases that amplify or inhibit these pathways also lead to disorders of water handling. Urea transport can also regulate the ability to concentrate or dilute the urine. This pathway is also implicated in cyst growth in ADPKD. This session explores how the last decade of findings has increased our understanding of novel regulators of aquaporin 2, which has implications for water handling and kidney diseases.

Learning Objective(s)

  • Discuss the disorders of hyponatremia and hypernatremia due to defective vasopressin signaling in the collecting duct
  • Describe novel genetic findings that elucidate the function of the vasopressin 2 receptor
  • Describe novel intracellular and extracellular mechanisms of aquaporin 2 trafficking and abundance

Learning Pathway(s)

  • Cell and Transport Physiology
  • Genetic Diseases of the Kidneys


  • Lise Bankir, PhD
  • Mark A. Knepper, MD, PhD