Basic/Clinical Science Session
New Insights into Paracellular Transport and Tight Junction Architecture in Kidney
November 04, 2022 | 10:30 AM - 12:30 PM
Location: W230, Orange County Convention Center, West Building
Session Description
This session focuses on the paracellular junction and the mechanisms regulating permeability across kidney epithelia. In particular, discussion centers on the claudins involved in permitting this selective permeability and the molecular mechanisms regulating transport via the paracellular pathway. The field is rapidly expanding, with many new findings about the regulation of this pathway in recent years.
Learning Objective(s)
- Describe details of the paracellular shunt pathway
- Characterize the function of the claudins involved in regulating permeability
- Provide details about the physiology of electrolyte transport
Learning Pathway(s)
- Fluid, Electrolyte, and Acid-Base Disorders
- Bones, Stones, and Mineral Metabolism
Moderators
- Vivek Bhalla, MD, FASN
- Alan S.L. Yu, MBChB
Presentations
- Claudin-2 and -12 Form Independent Complementary Pores Required to Maintain Calcium Homeostasis
10:30 AM - 11:00 AM
R. Todd Alexander, MD, PhD
- Interaction Between Epithelial Sodium Channel (ENaC) and Claudin-8 Modulates Paracellular Permeability in Collecting Duct
11:00 AM - 11:30 AM
Ali Sassi, PhD
- Calcium Sensing and Claudin Regulation in Kidney
11:30 AM - 12:00 PM
Henrik Dimke, PhD
- Role of Claudin-10 Splice Variants in Paracellular Transport in Kidney and Underlying HELIX Syndrome
12:00 PM - 12:30 PM
Dorothee Günzel, PhD
