ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

New Insights into Paracellular Transport and Tight Junction Architecture in Kidney

November 04, 2022 | 10:30 AM - 12:30 PM

Location: W230, Orange County Convention Center‚ West Building

Session Description

This session focuses on the paracellular junction and the mechanisms regulating permeability across kidney epithelia. In particular, discussion centers on the claudins involved in permitting this selective permeability and the molecular mechanisms regulating transport via the paracellular pathway. The field is rapidly expanding, with many new findings about the regulation of this pathway in recent years.

Learning Objective(s)

  • Describe details of the paracellular shunt pathway
  • Characterize the function of the claudins involved in regulating permeability
  • Provide details about the physiology of electrolyte transport

Learning Pathway(s)

  • Fluid‚ Electrolyte‚ and Acid-Base Disorders
  • Bones‚ Stones‚ and Mineral Metabolism


  • Vivek Bhalla, MD, FASN
  • Alan S.L. Yu, MBChB