ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Clinical Practice Session

Why Allografts Fail: Clinical, Histopathological, and Molecular Approach to Chronic Allograft Injury, Including the Barbara T. Murphy, MB BAO BCh, Endowed Lectureship

November 03, 2022 | 04:30 PM - 06:00 PM

Location: WF3 Tangerine, Orange County Convention Center, West Building

Session Description

Chronic allograft injury is common after kidney transplantation and occurs in 40% to 50% of protocol biopsies performed 1 year after transplantation. Studies on protocol biopsies have provided important clues on how early changes in graft histology relate to long-term graft survival. In this session, experts discuss clinical approaches to a failing allograft and explore the etiologic factors responsible for chronic allograft injury, emphasizing immunologic factors such as chronic antibody and T cell-mediated rejection, recurrent or de novo glomerular diseases, polyomavirus nephropathy, and nonimmune mechanisms.

ASN gratefully acknowledges Verici Dx, Renalytix, and the American Society of Transplantation for supporting this lectureship.

Learning Objective(s)

  • Summarize updates to the Banff Classification of Allograft Pathology about chronic antibody-mediated rejection and the recent addition of chronic T cell-mediated rejection
  • Describe molecular diagnostic methods such as cell-free DNA, gene transcripts, and the molecular microscope
  • Specify the clinical approaches to a failing allograft, such as preparation for the next transplantation, dialysis, and adjustment of immunosuppression

Learning Pathway(s)

  • Kidney Transplantation


  • Roy D. Bloom, MD
  • Mark Haas, MD, PhD