Basic/Clinical Science Session
Regulatory, Inflammatory B Cells and Autoantibodies: From Bench to Human Translation
November 04, 2022 | 10:30 AM - 12:30 PM
Location: WF3 Tangerine, Orange County Convention Center‚ West Building
Session Description
B cells play important roles in either suppressing or promoting immune responses through the respective activity of regulatory B cells (Bregs) and proinflammatory effector B cells (Beffs). B cell depletion is now the therapy of choice for some autoimmune diseases, but depletion of B cells in the peritransplant period can promote rejection of both kidney and cardiac transplants, implicating a regulatory role of B cells. Autoantibodies have been shown to cause microvascular injury in kidney transplantation.
This session reviews the role of B cells and autoantibodies in transplantation.
Learning Objective(s)
- Explain the important role different B cell subsets have in transplantation
- Describe the balance of inflammatory to regulatory B cells and its possible clinical use as a biomarker for underlying immunological reactivity
- Discuss the role of autoantibodies and kidney injury
Learning Pathway(s)
- Kidney Transplantation
Moderators
- Mohammed Javeed Ansari, MD
- Paolo Cravedi, MD, PhD
Presentations
- Development of Antigen-Specific Memory B Cells During Alloimmunity
10:30 AM - 11:00 AM
Stanley C. Jordan, MD, FASN
- B Cell Cytokine Balance Early Post-Transplantation Is a Predictive Biomarker for Post-Transplant Outcomes
11:00 AM - 11:30 AM
Aravind Cherukuri, MD, PhD
- Human Bregs Expressing TIM-1 and TIGIT Exhibit Regulatory Activity That Correlates with Kidney Transplant Outcomes
11:30 AM - 12:00 PM
SangKon Oh, PhD
- Autoantibodies Contribute to Microvascular Rarefaction and Progressive Kidney Dysfunction
12:00 PM - 12:30 PM
Marie-Josee Hebert, MD