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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Regulatory, Inflammatory B Cells and Autoantibodies: From Bench to Human Translation

November 04, 2022 | 10:30 AM - 12:30 PM

Location: WF3 Tangerine, Orange County Convention Center‚ West Building

Session Description

B cells play important roles in either suppressing or promoting immune responses through the respective activity of regulatory B cells (Bregs) and proinflammatory effector B cells (Beffs). B cell depletion is now the therapy of choice for some autoimmune diseases, but depletion of B cells in the peritransplant period can promote rejection of both kidney and cardiac transplants, implicating a regulatory role of B cells. Autoantibodies have been shown to cause microvascular injury in kidney transplantation.
This session reviews the role of B cells and autoantibodies in transplantation.

Learning Objective(s)

  • Explain the important role different B cell subsets have in transplantation
  • Describe the balance of inflammatory to regulatory B cells and its possible clinical use as a biomarker for underlying immunological reactivity
  • Discuss the role of autoantibodies and kidney injury

Learning Pathway(s)

  • Kidney Transplantation


  • Mohammed Javeed Ansari, MD
  • Paolo Cravedi, MD, PhD