ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

What's the Time in the Tubule?

November 05, 2022 | 02:00 PM - 04:00 PM

Location: W230, Orange County Convention Center‚ West Building

Session Description

Systemic and local circadian clocks affect kidney function. This session outlines recent developments in the regulation of tubular function by clock genes in health and disease. The expert presenters explore the impact of the systemic as well as the tubular clock on circadian kidney sodium handling and BP. They examine how the clock genes regulate kidney metabolism and glucose transport, as well as the deleterious consequences of environmental circadian disruption on kidney function and outcome.

Learning Objective(s)

  • Define the impact of the systemic clock on the circadian regulation of kidney sodium handling
  • Describe the impact of the tubular clock on the circadian regulation of kidney sodium handling
  • Discuss the role of tubular clock genes in the regulation of kidney glucose handling
  • Explain how environmental circadian disruption determines kidney function rhythm and injury

Learning Pathway(s)

  • Fluid‚ Electrolyte‚ and Acid-Base Disorders
  • Kidney Biology and Physiology


  • Nirupama Ramkumar, MD, MPH, FASN
  • Tianxin Yang, PhD


  • Circadian Regulation of Kidney Sodium Handling: Systemic Clock
    02:00 PM - 02:30 PM
    David M. Pollock, PhD, FASN
  • Circadian Regulation of Kidney Sodium Handling: Tubular Clock
    02:30 PM - 03:00 PM
    Lauren G. Douma, PhD
    Hannah Mhairi Costello, MS, MSc, PhD
  • Tubular Clock Regulates Kidney Glucose Handling
    03:00 PM - 03:30 PM
    Xiaoyue Pan, PhD
  • Environmental Circadian Disruption and Kidney Function Rhythm and Injury
    03:30 PM - 04:00 PM
    Alec J. Davidson, PhD