ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Big Roles for Thin Limbs

November 03, 2022 | 10:30 AM - 12:30 PM

Location: W230, Orange County Convention Center, West Building

Session Description

The kidney medulla plays a key role in urine concentration, but many aspects of its organization and function remain poorly understood. In this session, the expert presenters first outline new information on spatial cortico-medullary gene expression and osmolality gradients and then dig deeper into the thin limbs. What can be learned from the anatomical organization and gene expression profiles of thin limbs? What is the role of their tight junctions? Ultimately, the new information is integrated into a better understanding of the inner workings and unique roles of thin limbs.

Learning Objective(s)

  • Define spatial cortico-medullary gene expression and osmolality gradients
  • Describe the anatomical organization and gene expression profiles of thin limbs
  • Discuss the relevance and regulation of the tight junctions of thin limbs
  • Explain the multiple and unique functions of thin limbs

Learning Pathway(s)

  • Fluid, Electrolyte, and Acid-Base Disorders
  • Kidney Biology and Physiology

Moderators

  • Christine Anne Klemens, PhD
  • Tong Wang, MD

Presentations