Basic/Clinical Science Session
Big Roles for Thin Limbs
November 03, 2022 | 10:30 AM - 12:30 PM
Location: W230, Orange County Convention Center‚ West Building
Session Description
The kidney medulla plays a key role in urine concentration, but many aspects of its organization and function remain poorly understood. In this session, the expert presenters first outline new information on spatial cortico-medullary gene expression and osmolality gradients and then dig deeper into the thin limbs. What can be learned from the anatomical organization and gene expression profiles of thin limbs? What is the role of their tight junctions? Ultimately, the new information is integrated into a better understanding of the inner workings and unique roles of thin limbs.
Learning Objective(s)
- Define spatial cortico-medullary gene expression and osmolality gradients
- Describe the anatomical organization and gene expression profiles of thin limbs
- Discuss the relevance and regulation of the tight junctions of thin limbs
- Explain the multiple and unique functions of thin limbs
Learning Pathway(s)
- Fluid‚ Electrolyte‚ and Acid-Base Disorders
- Kidney Biology and Physiology
Moderators
- Christine Anne Klemens, PhD
- Tong Wang, MD
Presentations
- New Insights on Spatial Cortico-Medullary Gene Expression and Osmolality Gradients
10:30 AM - 11:00 AM
Christian Hinze, DrMed, MD
- Lessons from Anatomical Organization and Gene Expression Profiles of Thin Limbs
11:00 AM - 11:30 AM
Thomas L. Pannabecker, MS, PhD, MBA
- Function and Regulation of the Tight Junctions of Thin Limbs
11:30 AM - 12:00 PM
Nina Himmerkus, MD
- Multiple Functions of Thin Limbs: From Flow Resistor to Urine Concentration
12:00 PM - 12:30 PM
Mark A. Knepper, MD, PhD