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To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Clinical Practice Session

The Many Faces of Drug-Induced Kidney Injury

November 05, 2022 | 04:30 PM - 06:00 PM

Location: WF3 Tangerine, Orange County Convention Center‚ West Building

Session Description

Medications remain an important cause of acute and chronic kidney diseases. Drugs promote kidney injury through various mechanisms. These include classical direct tubular injury through mitochondrial toxicity, intratubular crystal deposition, idiosyncratic tubulointerstitial inflammatory injury, and possibly the formation of intratubular casts. Practicing nephrologists should be familiar with the different processes by which drugs can cause kidney injury, how to recognize them, and how to devise a treatment plan.

Learning Objective(s)

  • List the drugs that cause acute tubular injury through targeting the mitochondria, the mechanisms of mitochondrial injury, and potential therapies
  • Outline the drugs that cause crystalline nephropathy and develop the correct management plan for patients who develop kidney injury
  • Describe a rational approach to making a diagnosis of drug-induced acute interstitial nephritis and the limitations of available diagnostic tools and current therapies
  • Evaluate the data on vancomycin-associated cast nephropathy and analyze the role of this injury in causing AKI

Learning Pathway(s)

  • Pharmacology
  • Pathology


  • Melanie S. Joy, PharmD, PhD, FASN
  • Namrata Krishnan, MBBS, MD