ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Where It Begins: Complex Genetic Drivers of Kidney Phenotypes

November 04, 2022 | 04:30 PM - 06:00 PM

Location: WF1 Tangerine, Orange County Convention Center‚ West Building

Session Description

Like most chronic conditions, CKD has a significant hereditable component. Collaborative cohorts like the VA Million Veteran Program (MVP) and CKD Genetics (CKDGen) Consortium are facilitating large-scale studies that evaluate genetic variants, epigenomic drivers, and transcriptome changes that influence CKD and cardiometabolic risk factors. This session explores the association of these genetic drivers with diabetic nephropathy, IgA nephopathy, and renal function parameters, including eGFR. An update in ancestry-specific drivers of GFR and kidney diseases, including APOL1, are also provided.

Learning Objective(s)

  • Identify genetic risk variants for nephropathy in diabetes from genome-wide association studies (GWAS)
  • Enumerate molecular targets in IgA nephropathy from GWAS
  • Discuss insights into kidney function and disease by integrating multiomics data from collaborative cohorts
  • Describe the application of "omics" study in facilitating precision medicine approaches in APOL1 nephropathy from more diversified cohorts

Learning Pathway(s)

  • Genetic Diseases and Development


  • Moumita Barua, MD
  • Afshin Parsa, MD, MPH, FASN


  • GWAS Identify Risk Variants in Diabetic Nephropathy
    04:30 PM - 04:50 PM
    Jose C. Florez, MD, PhD
  • GWAS-Defined Drug Targets in IgA Nephropathy
    04:50 PM - 05:10 PM
    Krzysztof Kiryluk, MD
  • Integrating Multiomics Data for a Better Understanding of Kidney Function and Disease
    05:10 PM - 05:30 PM
    Anna Kottgen, MD, MPH
    Pascal Schlosser, MS, PhD
  • APOL1: Toward Precision Medicine Approaches
    05:30 PM - 05:50 PM
    Adriana Hung, MD, MPH
  • Q&A
    05:50 PM - 06:00 PM