Basic/Clinical Science Session
Where It Begins: Complex Genetic Drivers of Kidney Phenotypes
November 04, 2022 | 04:30 PM - 06:00 PM
Location: WF1 Tangerine, Orange County Convention Center, West Building
Session Description
Like most chronic conditions, CKD has a significant hereditable component. Collaborative cohorts like the VA Million Veteran Program (MVP) and CKD Genetics (CKDGen) Consortium are facilitating large-scale studies that evaluate genetic variants, epigenomic drivers, and transcriptome changes that influence CKD and cardiometabolic risk factors. This session explores the association of these genetic drivers with diabetic nephropathy, IgA nephopathy, and renal function parameters, including eGFR. An update in ancestry-specific drivers of GFR and kidney diseases, including APOL1, are also provided.
Learning Objective(s)
- Identify genetic risk variants for nephropathy in diabetes from genome-wide association studies (GWAS)
- Enumerate molecular targets in IgA nephropathy from GWAS
- Discuss insights into kidney function and disease by integrating multiomics data from collaborative cohorts
- Describe the application of "omics" study in facilitating precision medicine approaches in APOL1 nephropathy from more diversified cohorts
Learning Pathway(s)
- Genetic Diseases and Development
Moderators
- Moumita Barua, MD
- Afshin Parsa, MD, MPH, FASN
Presentations
- GWAS Identify Risk Variants in Diabetic Nephropathy
04:30 PM - 04:50 PM
Jose C. Florez, MD, PhD
- GWAS-Defined Drug Targets in IgA Nephropathy
04:50 PM - 05:10 PM
Krzysztof Kiryluk, MD
- Integrating Multiomics Data for a Better Understanding of Kidney Function and Disease
05:10 PM - 05:30 PM
Anna Kottgen, MD, MPH
- APOL1: Toward Precision Medicine Approaches
05:30 PM - 05:50 PM
Adriana Hung, MD, MPH
- Q&A
05:50 PM - 06:00 PM
