ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Extracellular Matrix Pathobiology in CKD and Alport Syndrome

November 04, 2022 | 02:00 PM - 04:00 PM

Location: WF1 Tangerine, Orange County Convention Center‚ West Building

Session Description

Genetic studies in disease- and population-based cohorts have expanded the clinical spectrum associated with pathogenic variants in type IV collagen. This has highlighted a need to understand the extracellular matrix (ECM) and its role in filtration function. This session explores the patient perspective on research and education in the area, biologic mechanisms linking the ECM to glomerular filtration, and model systems. Considerations for potential therapeutic approaches are also discussed, including gene editing.

Learning Objective(s)

  • Summarize research and education priorities important to the Alport syndrome community
  • Outline the composition of the ECM in health, aging, and disease
  • List gene editing strategies for Alport syndrome
  • Identify therapeutic strategies in Alport syndrome

Learning Pathway(s)

  • Genetic Diseases and Development


  • Tomoko Horinouchi, MD, PhD
  • Roser Torra, MD, PhD


  • Update on the Alport Syndrome Community, Research, and Education Efforts
    02:00 PM - 02:30 PM
    B. Andre Weinstock, PhD
  • Kidney Basement Membrane Composition, Regulators, and Human Disease Associations
    02:30 PM - 03:00 PM
    Rachel Lennon, MBBS, PhD
  • Developing Gene Editing Approaches in Alport Syndrome
    03:00 PM - 03:30 PM
    Jeffrey H. Miner, PhD, FASN
  • Therapeutic Development in Alport Syndrome
    03:30 PM - 04:00 PM
    Oliver Gross, DrMed