ASN's Mission

To create a world without kidney diseases, the ASN Alliance for Kidney Health elevates care by educating and informing, driving breakthroughs and innovation, and advocating for policies that create transformative changes in kidney medicine throughout the world.

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Kidney Week

Basic/Clinical Science Session

Podocyte Development, Disease, and Stem Cell Research

November 03, 2022 | 10:30 AM - 12:30 PM

Location: W240, Orange County Convention Center, West Building

Session Description

Podocytes are highly specialized cells of the glomerulus that prevent plasma proteins from entering the urinary ultrafiltrate by providing a barrier comprising filtration slits between foot processes. When podocytes are injured or lost, their elaborate structure is physically altered in a process termed "foot process effacement," which is found in many proteinuric kidney diseases. This session addresses the maturation of podocytes, their intricate cytoskeleton, and how podocytes can be generated from human amniotic fluid and explores the concept of "glomerulus on a chip."

Learning Objective(s)

  • Describe the differentiation stages of podocytes necessary for their function
  • Summarize the intricate actin cytoskeleton of the podocyte in animal models and in human cells
  • Explain how injured podocytes undergo reprogramming of their transcriptome

Learning Pathway(s)

  • Genetic Diseases and Development
  • Pediatric Nephrology

Moderators

  • Tobias B. Huber, MD, FASN
  • Oliver Wessely, PhD

Presentations