Basic/Clinical Science Session
Podocyte Development, Disease, and Stem Cell Research
November 03, 2022 | 10:30 AM - 12:30 PM
Location: W240, Orange County Convention Center, West Building
Session Description
Podocytes are highly specialized cells of the glomerulus that prevent plasma proteins from entering the urinary ultrafiltrate by providing a barrier comprising filtration slits between foot processes. When podocytes are injured or lost, their elaborate structure is physically altered in a process termed "foot process effacement," which is found in many proteinuric kidney diseases. This session addresses the maturation of podocytes, their intricate cytoskeleton, and how podocytes can be generated from human amniotic fluid and explores the concept of "glomerulus on a chip."
Learning Objective(s)
- Describe the differentiation stages of podocytes necessary for their function
- Summarize the intricate actin cytoskeleton of the podocyte in animal models and in human cells
- Explain how injured podocytes undergo reprogramming of their transcriptome
Learning Pathway(s)
- Genetic Diseases and Development
- Pediatric Nephrology
Moderators
- Tobias B. Huber, MD, FASN
- Oliver Wessely, PhD
Presentations
- 3D Visualization of the Podocyte Actin Network with Leading-Edge Approaches
10:30 AM - 11:00 AM
Hani Suleiman, MD, PhD
- Defining the Maturation of Kidney Cells with Single-Cell Sequencing and Functional Predictions
11:00 AM - 11:30 AM
Ryuichi Nishinakamura, MD, PhD
- Podocyte Repair After Injury: Reprogramming the Transcriptome
11:30 AM - 12:00 PM
Jordan A. Kreidberg, MD, PhD
- Podocytes from Amniotic Fluid, Glomeruli on a Chip, and Alport Syndrome
12:00 PM - 12:30 PM
Laura Perin, PhD
